Detailed information NTG0360492

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: FCF09_RS01270
• Genome accession: NZ_CP039729
• Coordinates: 261746..263035 (-)
• Length: 429 a.a.
• NCBI ID: WP_002294152.1
• Uniprot ID: A0AAV3GR07
• Organism: Enterococcus faecium strain ZY2
• Function: repress competence development (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	260344..261639	261746..263035	flank	107

Gene organization within MGE regions

Location: 260344..263035

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FCF09_RS01265 (FCF09_01330)	-	260344..261639 (+)	1296	WP_002297218.1	ISL3-like element ISEfa11 family transposase	-
FCF09_RS01270 (FCF09_01335)	htrA	261746..263035 (-)	1290	WP_002294152.1	trypsin-like peptidase domain-containing protein	Regulator

Sequence

Protein

• Length: 429 a.a.
• Molecular weight: 44871.87 Da
• Isoelectric Point: 4.5419

>NTDB_id=360492 FCF09_RS01270 WP_002294152.1 261746..263035(-) (htrA) [Enterococcus faecium strain ZY2]
MDRKNVTPKMKKSKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide

• Length: 1290 bp

>NTDB_id=360492 FCF09_RS01270 WP_002294152.1 261746..263035(-) (htrA) [Enterococcus faecium strain ZY2]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAGTAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAGAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGACTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACGAATAATCACGTAGTAGATGGCCAGCAAGGTCTTGAAGTCTTGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACAGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAGCCTGCGATTGCGATTGGTTCCCCACTAGGAT
CTGAATATGCAAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTGACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTTAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA

Domains

Predicted by InterproScan.

• Peptidase family M50 (Peptidase_M50) (9-417)

• PDZ domain (PDZ_2) (317-414)

• Trypsin-like peptidase domain (Trypsin_2) (127-272)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	53.269	96.27	0.513
htrA	Streptococcus mutans UA159	59.887	82.517	0.494
htrA	Streptococcus mitis NCTC 12261	52.778	92.308	0.487
htrA	Streptococcus pneumoniae TIGR4	59.05	78.555	0.464
htrA	Streptococcus pneumoniae Rx1	59.05	78.555	0.464
htrA	Streptococcus pneumoniae D39	59.05	78.555	0.464
htrA	Streptococcus pneumoniae R6	59.05	78.555	0.464