Detailed information    

insolico Bioinformatically predicted

Overview

Name   agrA   Type   Regulator
Locus tag   E8M03_RS10635 Genome accession   NZ_CP039448
Coordinates   2103160..2103876 (+) Length   238 a.a.
NCBI ID   WP_000688492.1    Uniprot ID   A0A7U7IEW1
Organism   Staphylococcus aureus strain VGC1     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2098160..2108876
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E8M03_RS10605 (E8M03_10705) - 2098377..2099003 (+) 627 WP_000522383.1 nitroreductase family protein -
  E8M03_RS10610 (E8M03_10710) - 2099364..2100149 (+) 786 WP_000867953.1 carbon-nitrogen family hydrolase -
  E8M03_RS14910 hld 2100748..2100828 (-) 81 WP_000046023.1 delta-hemolysin -
  E8M03_RS10620 (E8M03_10720) agrB 2101118..2101687 (+) 570 WP_001105712.1 accessory gene regulator AgrB -
  E8M03_RS10625 (E8M03_10725) agrD 2101684..2101824 (+) 141 WP_001093929.1 cyclic lactone autoinducer peptide AgrD -
  E8M03_RS10630 (E8M03_10730) agrC 2101849..2103141 (+) 1293 WP_025175272.1 quorum-sensing sensor histidine kinase AgrC -
  E8M03_RS10635 (E8M03_10735) agrA 2103160..2103876 (+) 717 WP_000688492.1 quorum-sensing response regulator AgrA Regulator
  E8M03_RS10640 (E8M03_10740) - 2103948..2104055 (+) 108 WP_031844951.1 hypothetical protein -
  E8M03_RS10645 (E8M03_10745) - 2104243..2105202 (-) 960 WP_001253300.1 carbohydrate kinase -
  E8M03_RS10650 (E8M03_10750) - 2105199..2106683 (-) 1485 WP_000141422.1 sucrose-6-phosphate hydrolase -
  E8M03_RS10655 (E8M03_10755) - 2106832..2107782 (-) 951 WP_000790321.1 LacI family DNA-binding transcriptional regulator -

Sequence

Protein


Download         Length: 238 a.a.        Molecular weight: 27905.90 Da        Isoelectric Point: 6.0927

>NTDB_id=358686 E8M03_RS10635 WP_000688492.1 2103160..2103876(+) (agrA) [Staphylococcus aureus strain VGC1]
MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSKDNSVETIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI

Nucleotide


Download         Length: 717 bp        

>NTDB_id=358686 E8M03_RS10635 WP_000688492.1 2103160..2103876(+) (agrA) [Staphylococcus aureus strain VGC1]
ATGAAAATTTTCATTTGCGAAGACGATCCAAAACAAAGAGAAAACATGGTTACCATTATTAAAAATTATATAATGATAGA
AGAAAAGCCTATGGAAATTGCCCTCGCAACTGATAATCCTTATGAGGTGCTTGAGCAAGCTAAAAATATGAATGACATAG
GCTGTTACTTTTTAGATATTCAACTTTCAACTGATATTAATGGTATCAAATTAGGCAGTGAAATTCGTAAGCATGATCCA
GTTGGTAACATTATATTTGTTACGAGTCACAGTGAACTTACCTATTTAACGTTTGTCTACAAAGTTGCAGCGATGGATTT
TATTTTTAAAGATGATCCAGCTGAATTAAGAACTCGAATTATAGACTGTTTAGAAACTGCACATACACGCTTACAATTGT
TGTCTAAAGATAATAGCGTTGAAACGATTGAATTAAAACGTGGCAGTAATTCAGTGTATGTTCAATATGATGATATTATG
TTTTTTGAATCATCAACAAAATCTCACAGACTCATTGCCCATTTAGATAACCGTCAAATTGAATTTTATGGTAATTTAAA
AGAACTGAGTCAATTAGATGATCGTTTCTTTAGATGTCATAATAGCTTTGTCGTCAATCGCCATAATATTGAATCTATAG
ATTCGAAAGAGCGAATTGTCTATTTTAAAAATAAAGAACACTGCTATGCATCGGTGAGAAACGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-120)

LytTr DNA-binding domain (LytTR)

(151-237)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7U7IEW1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  agrA Staphylococcus aureus N315

100

100

1

Multiple sequence alignment