Detailed information NTG0357351

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E1950_RS09310
• Genome accession: NZ_CP039162
• Coordinates: 1861719..1862762 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain Lr12
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1856719..1867762

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E1950_RS09280 (E1950_09460)	-	1857140..1858396 (-)	1257	WP_001795108.1	aminopeptidase	-
E1950_RS09285 (E1950_09465)	-	1858399..1858599 (-)	201	WP_000180460.1	DUF1128 family protein	-
E1950_RS09290 (E1950_09470)	-	1858746..1859210 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
E1950_RS09295 (E1950_09475)	-	1859217..1859492 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
E1950_RS09300 (E1950_09480)	-	1859770..1860987 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
E1950_RS09305 (E1950_09485)	vraR	1861100..1861729 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
E1950_RS09310 (E1950_09490)	vraS	1861719..1862762 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E1950_RS09315 (E1950_09495)	liaF	1862759..1863460 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E1950_RS09320 (E1950_09500)	-	1863475..1863861 (-)	387	WP_001110179.1	hypothetical protein	-
E1950_RS09325 (E1950_09505)	map	1864078..1864836 (-)	759	WP_103152251.1	type I methionyl aminopeptidase	-
E1950_RS09330 (E1950_09510)	-	1865308..1866294 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
E1950_RS09335 (E1950_09520)	-	1866725..1867138 (-)	414	WP_001557448.1	hypothetical protein	-
E1950_RS09340 (E1950_09525)	-	1867167..1867277 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=357351 E1950_RS09310 WP_001017131.1 1861719..1862762(-) (vraS) [Staphylococcus aureus strain Lr12]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=357351 E1950_RS09310 WP_001017131.1 1861719..1862762(-) (vraS) [Staphylococcus aureus strain Lr12]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1