Detailed information NTG0357310

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E1949_RS09745
• Genome accession: NZ_CP039160
• Coordinates: 1915820..1916863 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain Lr6
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1910820..1921863

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E1949_RS09715 (E1949_09885)	-	1911242..1912498 (-)	1257	WP_075583716.1	aminopeptidase	-
E1949_RS09720 (E1949_09890)	-	1912501..1912701 (-)	201	WP_000180460.1	DUF1128 family protein	-
E1949_RS09725 (E1949_09895)	-	1912848..1913312 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
E1949_RS09730 (E1949_09900)	-	1913319..1913594 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
E1949_RS09735 (E1949_09905)	-	1913872..1915089 (+)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
E1949_RS09740 (E1949_09910)	vraR	1915201..1915830 (-)	630	WP_000153528.1	two-component system response regulator VraR	Regulator
E1949_RS09745 (E1949_09915)	vraS	1915820..1916863 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E1949_RS09750 (E1949_09920)	liaF	1916860..1917561 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E1949_RS09755 (E1949_09925)	-	1917576..1917962 (-)	387	WP_001110179.1	hypothetical protein	-
E1949_RS09760 (E1949_09930)	map	1918179..1918937 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E1949_RS09765 (E1949_09935)	-	1919409..1920395 (+)	987	WP_000999718.1	aromatic acid exporter family protein	-
E1949_RS09770 (E1949_09945)	-	1920826..1921239 (-)	414	WP_001837637.1	hypothetical protein	-
E1949_RS09775 (E1949_09950)	-	1921268..1921378 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=357310 E1949_RS09745 WP_001017131.1 1915820..1916863(-) (vraS) [Staphylococcus aureus strain Lr6]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=357310 E1949_RS09745 WP_001017131.1 1915820..1916863(-) (vraS) [Staphylococcus aureus strain Lr6]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1