Detailed information NTG0355557

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E5Z44_RS11215
• Genome accession: NZ_CP038807
• Coordinates: 2365315..2366358 (-)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain APC 3758
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2360315..2371358

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E5Z44_RS11185 (E5Z44_11330)	-	2360736..2361974 (-)	1239	WP_002461326.1	aminopeptidase	-
E5Z44_RS11190 (E5Z44_11335)	-	2361987..2362172 (-)	186	WP_002492715.1	DUF1128 domain-containing protein	-
E5Z44_RS11195 (E5Z44_11340)	-	2362336..2362800 (+)	465	WP_002492719.1	low molecular weight protein-tyrosine-phosphatase	-
E5Z44_RS11200 (E5Z44_11345)	-	2362807..2363091 (+)	285	WP_002461330.1	YtxH domain-containing protein	-
E5Z44_RS11205 (E5Z44_11350)	-	2363294..2364523 (+)	1230	WP_002492699.1	YihY/virulence factor BrkB family protein	-
E5Z44_RS11210 (E5Z44_11355)	vraR	2364696..2365325 (-)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
E5Z44_RS11215 (E5Z44_11360)	vraS	2365315..2366358 (-)	1044	WP_002461334.1	sensor histidine kinase	Regulator
E5Z44_RS11220 (E5Z44_11365)	liaF	2366355..2367056 (-)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
E5Z44_RS11225 (E5Z44_11370)	-	2367081..2367467 (-)	387	WP_002477960.1	hypothetical protein	-
E5Z44_RS11230 (E5Z44_11375)	map	2367593..2368348 (-)	756	WP_002461338.1	type I methionyl aminopeptidase	-
E5Z44_RS11235 (E5Z44_11380)	-	2368593..2369573 (+)	981	WP_002492696.1	FUSC family protein	-
E5Z44_RS11240 (E5Z44_11385)	-	2369707..2371068 (+)	1362	WP_037540479.1	FAD-dependent oxidoreductase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=355557 E5Z44_RS11215 WP_002461334.1 2365315..2366358(-) (vraS) [Staphylococcus lugdunensis strain APC 3758]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=355557 E5Z44_RS11215 WP_002461334.1 2365315..2366358(-) (vraS) [Staphylococcus lugdunensis strain APC 3758]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCACTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911