Detailed information NTG0355202

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SaO268_RS10640
• Genome accession: NZ_CP038612
• Coordinates: 2034478..2035521 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain O268
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2029478..2040521

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SaO268_RS10610 (SaO268_1957)	-	2029899..2031155 (-)	1257	WP_001793428.1	aminopeptidase	-
SaO268_RS10615 (SaO268_1958)	-	2031158..2031358 (-)	201	WP_000180462.1	DUF1128 family protein	-
SaO268_RS10620 (SaO268_1959)	-	2031505..2031969 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SaO268_RS10625 (SaO268_1960)	-	2031976..2032251 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SaO268_RS10630 (SaO268_1961)	-	2032529..2033746 (+)	1218	WP_000037094.1	YihY/virulence factor BrkB family protein	-
SaO268_RS10635 (SaO268_1962)	vraR	2033859..2034488 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
SaO268_RS10640 (SaO268_1963)	vraS	2034478..2035521 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SaO268_RS10645 (SaO268_1964)	liaF	2035518..2036219 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SaO268_RS10650 (SaO268_1965)	-	2036234..2036620 (-)	387	WP_001110180.1	hypothetical protein	-
SaO268_RS10655 (SaO268_1966)	map	2036837..2037595 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SaO268_RS10660 (SaO268_1967)	-	2038167..2039153 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
SaO268_RS10665 (SaO268_1968)	-	2039345..2039758 (-)	414	WP_014532664.1	hypothetical protein	-
SaO268_RS10670	-	2039787..2039899 (-)	113	Protein_2003	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=355202 SaO268_RS10640 WP_001017131.1 2034478..2035521(-) (vraS) [Staphylococcus aureus strain O268]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=355202 SaO268_RS10640 WP_001017131.1 2034478..2035521(-) (vraS) [Staphylococcus aureus strain O268]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1