Detailed information NTG0352980

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SaO331_RS09525
• Genome accession: NZ_CP038269
• Coordinates: 1886636..1887679 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain O331 isolate B114
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1881636..1892679

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SaO331_RS09495 (SaO331_1741)	-	1882057..1883313 (-)	1257	WP_078065149.1	aminopeptidase	-
SaO331_RS09500 (SaO331_1742)	-	1883316..1883516 (-)	201	WP_000180460.1	DUF1128 family protein	-
SaO331_RS09505 (SaO331_1743)	-	1883663..1884127 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SaO331_RS09510 (SaO331_1744)	-	1884134..1884409 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SaO331_RS09515 (SaO331_1745)	-	1884687..1885904 (+)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
SaO331_RS09520 (SaO331_1746)	vraR	1886017..1886646 (-)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
SaO331_RS09525 (SaO331_1747)	vraS	1886636..1887679 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SaO331_RS09530 (SaO331_1748)	liaF	1887676..1888377 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SaO331_RS09535 (SaO331_1749)	-	1888392..1888778 (-)	387	WP_001110179.1	hypothetical protein	-
SaO331_RS09540 (SaO331_1750)	map	1888995..1889753 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SaO331_RS09545 (SaO331_1751)	-	1890282..1891268 (+)	987	WP_000999708.1	aromatic acid exporter family protein	-
SaO331_RS09550 (SaO331_1752)	-	1891701..1892114 (-)	414	WP_025174552.1	hypothetical protein	-
SaO331_RS09555	-	1892143..1892253 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=352980 SaO331_RS09525 WP_001017131.1 1886636..1887679(-) (vraS) [Staphylococcus aureus strain O331 isolate B114]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=352980 SaO331_RS09525 WP_001017131.1 1886636..1887679(-) (vraS) [Staphylococcus aureus strain O331 isolate B114]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1