Detailed information NTG0352555

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: ES300_RS08165
• Genome accession: NZ_CP038251
• Coordinates: 1625565..1626224 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565021.1
• Uniprot ID: C1C962
• Organism: Streptococcus pneumoniae strain TVO_1901944
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1620565..1631224

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ES300_RS08140 (ES300_08570)	-	1620870..1621187 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
ES300_RS08145 (ES300_08575)	-	1621202..1622098 (-)	897	WP_000825669.1	PEP phosphonomutase	-
ES300_RS08150 (ES300_08580)	-	1622101..1623363 (-)	1263	WP_000413335.1	PTS sugar transporter subunit IIC	-
ES300_RS08155 (ES300_08585)	-	1623643..1624821 (+)	1179	WP_000175875.1	ROK family transcriptional regulator	-
ES300_RS08160 (ES300_08590)	-	1625049..1625495 (-)	447	WP_000155418.1	GNAT family N-acetyltransferase	-
ES300_RS08165 (ES300_08595)	cclA/cilC	1625565..1626224 (+)	660	WP_000565021.1	A24 family peptidase	Machinery gene
ES300_RS08170 (ES300_08600)	-	1626276..1627427 (-)	1152	WP_000481760.1	XRE family transcriptional regulator	-
ES300_RS08175 (ES300_08605)	-	1627442..1628173 (-)	732	Protein_1645	hypothetical protein	-
ES300_RS08180 (ES300_08610)	-	1628393..1628503 (+)	111	Protein_1646	prepilin peptidase	-
ES300_RS08185 (ES300_08615)	trpA	1628475..1629251 (-)	777	WP_001127048.1	tryptophan synthase subunit alpha	-
ES300_RS08190 (ES300_08620)	trpB	1629244..1630467 (-)	1224	WP_000331289.1	tryptophan synthase subunit beta	-
ES300_RS08195 (ES300_08625)	-	1630445..1631044 (-)	600	WP_000169887.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24854.98 Da
• Isoelectric Point: 7.9575

>NTDB_id=352555 ES300_RS08165 WP_000565021.1 1625565..1626224(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901944]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=352555 ES300_RS08165 WP_000565021.1 1625565..1626224(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901944]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTAGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATTCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: C1C962

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae Rx1	97.717	100	0.977
cclA/cilC	Streptococcus pneumoniae D39	97.717	100	0.977
cclA/cilC	Streptococcus pneumoniae R6	97.717	100	0.977
cclA/cilC	Streptococcus pneumoniae TIGR4	95.89	100	0.959
cclA/cilC	Streptococcus mitis SK321	93.151	100	0.932
cclA/cilC	Streptococcus mitis NCTC 12261	87.671	100	0.877