Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   ES300_RS02450 Genome accession   NZ_CP038251
Coordinates   488559..490712 (-) Length   717 a.a.
NCBI ID   WP_000205168.1    Uniprot ID   A0A4J2GMP9
Organism   Streptococcus pneumoniae strain TVO_1901944     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 483559..495712
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ES300_RS02420 (ES300_02550) - 483896..484225 (-) 330 WP_000132572.1 hypothetical protein -
  ES300_RS02425 (ES300_02555) - 484500..484838 (+) 339 WP_000682121.1 LytTR family DNA-binding domain-containing protein -
  ES300_RS02430 (ES300_02560) - 484843..485576 (+) 734 Protein_486 response regulator transcription factor -
  ES300_RS02435 (ES300_02565) - 485590..486930 (+) 1341 WP_001099890.1 sensor histidine kinase -
  ES300_RS02440 (ES300_02570) blpC 486975..487130 (-) 156 WP_000358814.1 quorum-sensing system pheromone BlpC -
  ES300_RS02445 (ES300_02575) - 487187..488548 (-) 1362 WP_001069067.1 bacteriocin secretion accessory protein -
  ES300_RS02450 (ES300_02580) comA/nlmT 488559..490712 (-) 2154 WP_000205168.1 peptide cleavage/export ABC transporter BlpA Regulator
  ES300_RS02455 (ES300_02585) blpI 490993..491190 (+) 198 WP_001093259.1 bacteriocin-like peptide BlpI -
  ES300_RS02460 (ES300_02595) blpJ 491656..491925 (+) 270 WP_001093249.1 bacteriocin-like peptide BlpJ -
  ES300_RS02465 - 491994..492223 (+) 230 Protein_493 Blp family class II bacteriocin -
  ES300_RS02470 (ES300_02605) - 492226..492345 (+) 120 WP_000346298.1 PncF family bacteriocin immunity protein -
  ES300_RS02475 (ES300_02610) - 492642..492806 (+) 165 WP_000727118.1 hypothetical protein -
  ES300_RS02480 (ES300_02615) - 492803..493207 (+) 405 WP_000846943.1 hypothetical protein -
  ES300_RS02485 (ES300_02620) - 493410..494214 (+) 805 WP_128903587.1 IS5 family transposase -
  ES300_RS02490 (ES300_02625) blpM 494364..494618 (+) 255 WP_000379879.1 two-peptide bacteriocin subunit BlpM -
  ES300_RS02495 (ES300_02630) blpN 494634..494837 (+) 204 WP_001099492.1 two-peptide bacteriocin subunit BlpN -
  ES300_RS02500 (ES300_02640) cipB 495081..495230 (+) 150 WP_001818346.1 bacteriocin-like peptide BlpO Regulator
  ES300_RS10850 - 495266..495331 (+) 66 Protein_501 ComC/BlpC family peptide pheromone/bacteriocin -
  ES300_RS02505 (ES300_02645) - 495334..495453 (+) 120 WP_000346296.1 PncF family bacteriocin immunity protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80787.78 Da        Isoelectric Point: 7.6796

>NTDB_id=352529 ES300_RS02450 WP_000205168.1 488559..490712(-) (comA/nlmT) [Streptococcus pneumoniae strain TVO_1901944]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLVIGDPDPSVKITKMSKERFFSEWTGVAIFLAPKPSYQPHKDKKNGLLSFLPL
IFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVITYILQQVMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLISIPIYMF
IIFSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLSKYSILQTSLKQGTKL
VLNILILWFGAQLVMSSKISIGQLITFNTLFSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVESEFQVQENPVHSHFL
MGDIEFDDLSYKYGFGRDTLTDINLTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINHQDIKNIDKKVLRRHI
NYLPQQAYIFNGSILENLTLGGNHMISQEDILKACEVAEIRQDIERMPMGYQTQLSDGAGLSGGQKQRIALARALLTKSP
VLILDEATSGLDVLTEKKVIDNLMSLTDKTILFVAHRLSIAERTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=352529 ES300_RS02450 WP_000205168.1 488559..490712(-) (comA/nlmT) [Streptococcus pneumoniae strain TVO_1901944]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGGCCTGTTCAAGCAGATAAAACTCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGGTTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTCTGAATGGACTGGAG
TAGCTATTTTTCTAGCTCCCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCTTCCTTCCTCTG
ATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTTCTTA
TTATCTCCAAGGAATCTTAGATGAATACATCCCAAATCAGATGAAATCAACTTTAGGAATCATCTCAGTTGGTCTGGTTA
TCACCTATATCCTCCAACAAGTCATGAGCTTCTCCAGAGATTATCTCCTAACCGTTCTGAGCCAGAGATTAAGCATTGAT
GTGATTTTATCCTATATTCGCCATATTTTTGAACTTCCCATGTCTTTCTTTGCGACACGTCGTACAGGAGAAATCATTTC
ACGGTTCACAGATGCTAACTCTATTATAGATGCCTTGGCTTCTACCATTCTTTCTCTTTTCCTGGATGTTTCTATTCTGA
TTCTTGTAGGGGGCGTCTTACTGGCACAAAACCCTAATCTCTTCCTTCTTTCTCTTATTTCTATTCCTATATACATGTTC
ATCATCTTTTCTTTTATGAAGCCTTTCGAAAAAATGAACCATGATGTCATGCAAAGTAATTCTATGGTTAGCTCTGCCAT
TATCGAAGATATCAACGGGATTGAAACTATAAAGTCGCTCACGAGTGAAGAAAATCGCTATCAAAATATAGACAGCGAAT
TTGTAGATTATTTGGAAAAATCCTTTAAGCTCAGTAAATATTCTATTTTACAAACAAGTTTAAAGCAGGGAACAAAATTA
GTTCTGAATATCCTTATCCTATGGTTTGGCGCTCAATTAGTCATGTCGAGTAAAATTTCTATCGGTCAGCTGATTACCTT
TAACACACTTTTTTCTTACTTTACAACTCCTATGGAAAATATTATCAACCTCCAAACCAAACTCCAATCTGCGAAGGTCG
CTAATAACCGTTTGAACGAAGTCTATCTAGTCGAATCTGAATTTCAAGTTCAAGAAAACCCTGTTCATTCACATTTTTTG
ATGGGCGATATTGAATTTGATGACCTTTCTTATAAGTATGGTTTTGGACGAGATACCTTAACAGATATTAATCTCACGAT
TAAACAAGGAGATAAGGTTAGCCTAGTTGGAGTTAGTGGTTCTGGTAAAACAACTTTAGCCAAAATGATTGTCAATTTCT
TTGAACCCTACAAAGGGCATATTTCCATCAATCATCAGGATATTAAAAACATTGATAAAAAAGTCTTGCGCCGTCATATT
AATTACCTACCCCAACAAGCCTATATCTTTAATGGCTCTATTTTGGAAAACTTAACCTTGGGCGGTAATCATATGATTAG
TCAAGAAGATATTCTAAAAGCTTGTGAAGTAGCTGAAATCCGTCAAGACATTGAAAGAATGCCTATGGGCTATCAAACTC
AGCTCTCTGATGGAGCTGGTCTATCAGGAGGACAGAAGCAACGAATCGCTCTCGCTCGTGCTCTTTTAACTAAATCTCCT
GTTTTAATACTAGATGAAGCTACTAGCGGTCTTGATGTCTTGACTGAGAAAAAAGTTATAGATAATCTTATGTCCCTAAC
TGATAAAACCATTCTCTTTGTAGCCCATCGTCTCAGTATAGCCGAACGAACCAACCGTGTCATTGTTCTTGACCAGGGGA
AAATCATTGAAGTTGGTAGCCACCAAGAGTTAATGCAGGCGCAAGGTTTCTACCATCATCTATTCAATAAATAA

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(169-438)

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-649)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4J2GMP9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

71.608

99.721

0.714
  comA Streptococcus mitis NCTC 12261

66.199

99.442

0.658
  comA Streptococcus pneumoniae Rx1

65.638

99.442

0.653
  comA Streptococcus pneumoniae R6

65.638

99.442

0.653
  comA Streptococcus pneumoniae D39

65.638

99.442

0.653
  comA Streptococcus mitis SK321

65.638

99.442

0.653
  comA Streptococcus gordonii str. Challis substr. CH1

64.903

100

0.65
  comA Streptococcus pneumoniae TIGR4

65.358

99.442

0.65

Multiple sequence alignment