Detailed information NTG0352456

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E4J95_RS09540
• Genome accession: NZ_CP038229
• Coordinates: 1955663..1956706 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain MJ163
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1950663..1961706

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E4J95_RS09510 (E4J95_09965)	-	1951085..1952341 (-)	1257	WP_001793428.1	aminopeptidase	-
E4J95_RS09515 (E4J95_09970)	-	1952344..1952544 (-)	201	WP_000180460.1	DUF1128 family protein	-
E4J95_RS09520 (E4J95_09975)	-	1952691..1953155 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
E4J95_RS09525 (E4J95_09980)	-	1953162..1953437 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
E4J95_RS09530 (E4J95_09985)	-	1953715..1954932 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
E4J95_RS09535 (E4J95_09990)	vraR	1955044..1955673 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
E4J95_RS09540 (E4J95_09995)	vraS	1955663..1956706 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E4J95_RS09545 (E4J95_10000)	liaF	1956703..1957404 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E4J95_RS09550 (E4J95_10005)	-	1957419..1957805 (-)	387	WP_001110179.1	hypothetical protein	-
E4J95_RS09555 (E4J95_10010)	map	1958022..1958780 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E4J95_RS09560 (E4J95_10020)	-	1959311..1960297 (+)	987	WP_000999716.1	aromatic acid exporter family protein	-
E4J95_RS09565 (E4J95_10030)	-	1960787..1961200 (-)	414	WP_001670387.1	hypothetical protein	-
E4J95_RS09570 (E4J95_10035)	-	1961229..1961339 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=352456 E4J95_RS09540 WP_001017131.1 1955663..1956706(-) (vraS) [Staphylococcus aureus strain MJ163]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=352456 E4J95_RS09540 WP_001017131.1 1955663..1956706(-) (vraS) [Staphylococcus aureus strain MJ163]
ATGAACCATTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1