Detailed information NTG0351422

Bioinformatically predicted

Overview

• Name: comX/comX2
• Type: Regulator
• Locus tag: GL187_RS00060
• Genome accession: NZ_CP046379
• Coordinates: 12089..12568 (+)
• Length: 159 a.a.
• NCBI ID: WP_000588925.1
• Uniprot ID: A0A0H2UMS0
• Organism: Streptococcus pneumoniae strain 563
• Function: activate transcription of late competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 7089..17568

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GL187_RS00045 (GL187_00045)	tilS	8170..9447 (+)	1278	WP_024477995.1	tRNA lysidine(34) synthetase TilS	-
GL187_RS00050 (GL187_00050)	hpt	9451..9993 (+)	543	WP_000892185.1	hypoxanthine phosphoribosyltransferase	-
GL187_RS00055 (GL187_00055)	ftsH	10009..11967 (+)	1959	WP_000744557.1	ATP-dependent zinc metalloprotease FtsH	-
GL187_RS00060 (GL187_00060)	comX/comX2	12089..12568 (+)	480	WP_000588925.1	sigma-70 family RNA polymerase sigma factor	Regulator

Sequence

Protein

• Length: 159 a.a.
• Molecular weight: 19887.54 Da
• Isoelectric Point: 7.3798

>NTDB_id=351422 GL187_RS00060 WP_000588925.1 12089..12568(+) (comX/comX2) [Streptococcus pneumoniae strain 563]
MIKELYEEVQGTVYKCRNEYYLHLWELSDWEQEGMLCLHELISREEGLVDDIPRLRKYFKTKFRNRILDYIRKQESQKRR
YDKEPYEEVGEISHRISEGGLWLDDYYLFHETLRDYRNKQSKEKQEELERVLSNERFRGRQRVLRDLRIVFKEFTIRTH

Nucleotide

• Length: 480 bp

>NTDB_id=351422 GL187_RS00060 WP_000588925.1 12089..12568(+) (comX/comX2) [Streptococcus pneumoniae strain 563]
ATGATTAAAGAATTGTATGAAGAAGTCCAAGGGACTGTGTATAAGTGTAGAAATGAATATTACCTTCATTTATGGGAATT
GTCGGATTGGGAGCAAGAAGGCATGCTCTGCTTACATGAATTGATTAGTAGAGAAGAAGGACTGGTAGACGATATTCCAC
GTTTAAGGAAATATTTCAAGACCAAGTTTCGAAATCGAATTTTAGACTATATCCGTAAACAGGAAAGTCAGAAGCGTAGA
TACGATAAAGAACCCTATGAAGAAGTGGGTGAGATCAGTCATCGTATAAGTGAGGGGGGTCTCTGGCTAGATGATTATTA
TCTCTTTCATGAAACACTAAGAGATTATAGAAACAAACAAAGTAAAGAGAAACAAGAAGAACTAGAACGCGTCTTAAGCA
ATGAACGATTTCGAGGGCGTCAAAGAGTATTAAGAGACTTACGCATTGTGTTTAAGGAGTTTACTATCCGTACCCATTAG

Domains

No domain identified.

3D structure

• AlphaFold DB: A0A0H2UMS0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX/comX2	Streptococcus pneumoniae TIGR4	100	100	1
comX/comX1	Streptococcus pneumoniae TIGR4	100	100	1
comX/comX2	Streptococcus pneumoniae Rx1	99.371	100	0.994
comX/comX1	Streptococcus pneumoniae Rx1	99.371	100	0.994
comX/comX2	Streptococcus pneumoniae D39	99.371	100	0.994
comX/comX1	Streptococcus pneumoniae D39	99.371	100	0.994
comX/comX2	Streptococcus pneumoniae R6	99.371	100	0.994
comX/comX1	Streptococcus pneumoniae R6	99.371	100	0.994
comX/sigX/comX1/sigX1	Streptococcus mitis NCTC 12261	91.824	100	0.918
comX/sigX/comX2/sigX2	Streptococcus mitis NCTC 12261	91.824	100	0.918
comX/sigX/comX2/sigX2	Streptococcus mitis SK321	89.937	100	0.899
comX/sigX/comX1/sigX1	Streptococcus mitis SK321	88.608	99.371	0.881
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	48.718	98.113	0.478
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	48.718	98.113	0.478
comX/sigX	Streptococcus suis D9	46.358	94.969	0.44
comX/sigX	Streptococcus suis isolate S10	46.358	94.969	0.44
comX/sigX	Streptococcus suis P1/7	46.358	94.969	0.44
comX/sigX	Streptococcus mutans UA159	46	94.34	0.434
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	39.216	96.226	0.377
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	39.216	96.226	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	40	94.34	0.377
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	40	94.34	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	40	94.34	0.377
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	40	94.34	0.377
comX	Streptococcus salivarius SK126	38.926	93.711	0.365
comX	Streptococcus thermophilus LMG 18311	38.926	93.711	0.365
comX	Streptococcus thermophilus LMD-9	38.926	93.711	0.365