Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   GL189_RS03690 Genome accession   NZ_CP046360
Coordinates   728092..730350 (-) Length   752 a.a.
NCBI ID   WP_000882517.1    Uniprot ID   Q8DQD7
Organism   Streptococcus pneumoniae strain 574     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 723092..735350
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GL189_RS03670 (GL189_03765) tnpB 725458..725781 (-) 324 WP_000973421.1 IS66 family insertion sequence element accessory protein TnpB -
  GL189_RS03675 (GL189_03770) - 726042..726341 (-) 300 WP_000767193.1 DUF1827 family protein -
  GL189_RS03680 (GL189_03775) - 726506..726957 (-) 452 Protein_738 NUDIX hydrolase -
  GL189_RS03685 (GL189_03780) - 727039..727885 (+) 847 Protein_739 IS630 family transposase -
  GL189_RS03690 (GL189_03785) clpE 728092..730350 (-) 2259 WP_000882517.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  GL189_RS03695 (GL189_03790) - 730579..730809 (-) 231 WP_000443573.1 YkuJ family protein -
  GL189_RS03700 (GL189_03795) - 730999..731682 (+) 684 WP_001011633.1 amino acid ABC transporter permease -
  GL189_RS03705 (GL189_03800) - 731682..732416 (+) 735 WP_000140941.1 amino acid ABC transporter ATP-binding protein -
  GL189_RS03710 (GL189_03805) - 732570..733427 (+) 858 WP_000192081.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  GL189_RS03715 (GL189_03810) - 733564..734385 (+) 822 WP_000601064.1 hypothetical protein -
  GL189_RS03720 (GL189_03815) - 734399..735238 (+) 840 WP_024477834.1 NAD(P)H-hydrate dehydratase -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83840.26 Da        Isoelectric Point: 5.3713

>NTDB_id=351337 GL189_RS03690 WP_000882517.1 728092..730350(-) (clpE) [Streptococcus pneumoniae strain 574]
MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSLFKGMTDLNNRDFDPFGDFFNDLNNFRPSSNTPPIPP
TQSGGGYGGNGGYGSQNRGSAQTPPPSQEKGLLEEFGINVTEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSA
SDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVDETITILKGIQKKYEDYHHVQYTDAA
IEAAATLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRDQIAKYKEM
QKKKITDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKSHVIGQDDAVDKIAKAIRRNRVGLGTPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRHNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKTEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFKALSKDNLLQIVELMLADVNKRLSSNNIRLDVTDKVKEKLVDLGYDPKMGARPLRRTIQDYIEDTITDYYLENP
SEKDLKAVMTSKGNIQIKSAKKAEVKSSEKEK

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=351337 GL189_RS03690 WP_000882517.1 728092..730350(-) (clpE) [Streptococcus pneumoniae strain 574]
ATGCTTTGTCAAAACTGTAAAATTAACGACTCAACAATTCATCTTTACACCAATCTCAATGGAAAACAAAAACAAATTGA
CCTCTGTCAAAACTGCTATAAGATTATCAAAACAGATCCTAACAATAGCCTCTTCAAAGGTATGACGGATCTGAACAATC
GTGACTTCGATCCCTTTGGTGATTTCTTCAATGATCTAAACAATTTCAGACCTTCTAGCAATACTCCTCCTATTCCCCCA
ACCCAATCAGGTGGAGGTTACGGTGGAAACGGCGGTTATGGTTCCCAAAATCGTGGATCTGCTCAAACTCCGCCACCTAG
CCAAGAAAAAGGCCTGCTGGAAGAATTTGGTATTAATGTAACTGAAATTGCCCGTCGTGGAGACATTGACCCCGTTATTG
GGCGCGACGATGAGATTATCCGTGTCATCGAGATTCTCAATCGTAGAACCAAGAATAATCCTGTCCTTATCGGTGAACCT
GGTGTCGGAAAAACGGCCGTTGTCGAAGGTCTAGCTCAGAAAATTGTCGATGGCGATGTGCCACATAAACTCCAAGGTAA
ACAAGTCATCCGTCTGGATGTGGTTAGCTTAGTTCAAGGAACGGGGATTCGAGGACAATTTGAAGAACGCATGCAAAAAC
TCATGGAAGAAATTCGCAAACGTGAAGACATCATCCTCTTTATCGATGAAATCCATGAAATTGTTGGTGCTGGTTCTGCG
AGTGATGGTAATATGGACGCAGGAAATATCCTCAAGCCAGCCCTTGCTCGTGGAGAACTGCAACTAGTCGGTGCTACTAC
CCTCAATGAATACCGTATCATTGAAAAGGATGCTGCCCTCGAGCGTCGTATGCAGCCTGTTAAAGTCGATGAACCAACGG
TGGATGAAACAATCACTATTCTCAAAGGGATTCAAAAGAAATACGAAGATTACCACCACGTTCAATATACCGATGCTGCG
ATTGAAGCAGCTGCAACTCTTTCCAATCGCTACATCCAAGATCGCTTCTTGCCTGACAAGGCCATTGACCTCCTAGATGA
AGCTGGTTCTAAGATGAACTTGACCTTGAATTTTGTGGATCCTAAAGTAATTGATCAGCGCTTGATTGAGGCTGAAAATC
TCAAGTCTCAAGCTACACGAGAAGAAGATTTTGAGAAGGCGGCCTACTTCCGCGACCAGATTGCCAAGTATAAGGAAATG
CAAAAGAAAAAGATCACAGACCAGGATACTCCTATCATCAGCGAGAAAACTATTGAGCACATTATCGAGCAGAAAACCAA
TATCCCTGTTGGTGATTTGAAAGAGAAAGAACAATCTCAACTCATCCATCTAGCCGAAGATCTCAAGTCTCATGTTATTG
GCCAAGATGATGCAGTCGATAAGATTGCCAAGGCTATTCGCCGTAATCGTGTCGGACTTGGTACCCCTAACCGCCCAATC
GGAAGCTTCCTCTTCGTTGGACCAACTGGTGTCGGTAAGACAGAACTTTCCAAACAACTGGCTATCGAACTTTTTGGTTC
TGCTGATAGTATGATTCGCTTTGATATGAGTGAATACATGGAAAAACATAGTGTGGCTAAGTTGGTCGGCGCTCCTCCAG
GTTATGTTGGCTATGATGAGGCTGGTCAATTAACTGAAAAAGTTCGCCACAATCCGTATTCTCTCATCCTTCTCGATGAA
GTGGAAAAAGCTCACCCAGATGTTATGCACATGTTTCTTCAAGTCTTGGACGATGGTCGTTTGACAGACGGGCAAGGACG
CACCGTTAGCTTCAAGGATGCCATCATTATCATGACCTCAAATGCAGGTACAGGAAAGACCGAAGCTAGCGTTGGATTTG
GTGCTGCTAGAGAAGGACGTACCAATTCTGTCCTCGGTGAACTCGGTAACTTCTTTAGCCCAGAGTTTATGAACCGTTTT
GATGGCATTATCGAATTTAAGGCTCTCAGCAAGGATAACCTCCTTCAGATTGTCGAGCTCATGCTAGCAGATGTTAACAA
GCGCCTCTCTAGCAACAACATTCGTTTGGATGTAACTGACAAGGTCAAGGAAAAGTTGGTTGACCTAGGTTATGATCCAA
AAATGGGAGCACGCCCACTTCGTCGGACTATTCAAGACTATATTGAGGACACAATCACTGACTACTACCTTGAAAATCCA
AGCGAAAAAGATCTCAAAGCAGTTATGACTAGCAAGGGAAACATTCAGATTAAATCTGCCAAAAAAGCTGAAGTTAAAAG
TTCTGAAAAAGAAAAATAA

Domains

Predicted by InterProScan.

ATPase family associated with various cellular activities (AAA) (AAA)

(155-276)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(649-723)

AAA lid domain (AAA_lid_9)

(293-390)

AAA domain (Cdc48 subfamily) (AAA_2)

(478-641)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DQD7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

100

100

1
  clpE Streptococcus pneumoniae D39

100

100

1
  clpE Streptococcus pneumoniae R6

100

100

1
  clpE Streptococcus pneumoniae TIGR4

99.867

100

0.999
  clpE Streptococcus mutans UA159

82.731

99.335

0.822
  clpC Lactococcus lactis subsp. cremoris KW2

76.839

97.606

0.75
  clpC Bacillus subtilis subsp. subtilis str. 168

52.308

86.436

0.452
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.687

83.378

0.398
  clpC Streptococcus pneumoniae TIGR4

46.91

83.91

0.394
  clpC Streptococcus pneumoniae Rx1

46.91

83.91

0.394
  clpC Streptococcus pneumoniae D39

46.91

83.91

0.394
  clpC Streptococcus thermophilus LMD-9

46.795

82.979

0.388
  clpC Streptococcus mutans UA159

46.571

83.378

0.388
  clpC Streptococcus thermophilus LMG 18311

46.4

83.112

0.386