Detailed information NTG0350421

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: FOB91_RS06255
• Genome accession: NZ_CP046328
• Coordinates: 1289886..1292429 (-)
• Length: 847 a.a.
• NCBI ID: WP_012131025.1
• Uniprot ID: A8AZU4
• Organism: Streptococcus gordonii strain FDAARGOS_683
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1284886..1297429

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FOB91_RS06225 (FOB91_06225)	ruvA	1284998..1285588 (-)	591	WP_012131019.1	Holliday junction branch migration protein RuvA	Machinery gene
FOB91_RS06230 (FOB91_06230)	-	1285758..1286261 (+)	504	WP_012131020.1	helix-turn-helix domain-containing protein	-
FOB91_RS06235 (FOB91_06235)	-	1286245..1286766 (+)	522	WP_012131021.1	RDD family protein	-
FOB91_RS06240 (FOB91_06240)	hexB	1286802..1288745 (-)	1944	WP_012131022.1	DNA mismatch repair endonuclease MutL	Machinery gene
FOB91_RS06245 (FOB91_06245)	-	1288930..1289370 (+)	441	WP_012131023.1	LytTR family DNA-binding domain-containing protein	-
FOB91_RS06250 (FOB91_06250)	-	1289367..1289837 (+)	471	WP_012131024.1	DUF3021 domain-containing protein	-
FOB91_RS06255 (FOB91_06255)	hexA	1289886..1292429 (-)	2544	WP_012131025.1	DNA mismatch repair protein MutS	Machinery gene
FOB91_RS06260 (FOB91_06260)	argR	1292608..1293045 (-)	438	WP_008809983.1	arginine repressor	-
FOB91_RS06265 (FOB91_06265)	argS	1293174..1294862 (+)	1689	WP_012131026.1	arginine--tRNA ligase	-
FOB91_RS06270 (FOB91_06270)	-	1295091..1296026 (-)	936	WP_012131027.1	YitT family protein	-

Sequence

Protein

• Length: 847 a.a.
• Molecular weight: 95245.52 Da
• Isoelectric Point: 4.7958

>NTDB_id=350421 FOB91_RS06255 WP_012131025.1 1289886..1292429(-) (hexA) [Streptococcus gordonii strain FDAARGOS_683]
MATEKISPGMQQYLDIKKDYQDAFLLFRMGDFYELFYEDAVNAAQILEIALTSRNKNSENPIPMAGVPYHSAQQYIDVLI
ESGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPVGENNFLVALDRQEQAYGLAYMDLATGEFQVTSLADFDQ
ACGEIRNLRAREVVVGYCLSEDEQQILSKQMNLLLSEVEEAMEDVQLLGDELSSLEKQTAGKLLAYVFQTQMRELSHLKK
VHHYEIKDFLQMDYATKTSLDLTENARTGKKHGSLFWLMDETKTAMGGRLLRSWIQHPLIDKGRIIKRQDVVQVFLDYFF
ERSDLADSLKGVYDIERLVSRVSFGKTNPKDLLQLASTLSHVPQIRSILETIESPALESLVARLDAIPELENLISSAIDP
DAPQVITEGNIIRTGFDETLDQYRLVMREGTSWIADIEAKEREASGITNLKIDYNKKDGYYFHVTNSQLGNVPSHFFRKA
TLKNSERFGTEELARIEGEMLEAREKSANLEYEIFMRIREEVGKYIQRLQALAQTLATVDVLQSFAVVAESQHLVRPSFT
SSRSLQIKKGRHAVVEKVMGAQSYIPNSIELDQETDIQLITGPNMSGKSTYMRQLAMIVIMAQMGSYVPAEVASLPIFDA
IFTRIGAADDLVSGQSTFMVEMMEANRAIRQASERSLILFDELGRGTATYDGMALAQAIIEYIHDRTKAKTLFATHYHEL
TDLSSSLTRLENVHVATLEKDGQVTFLHKIEAGPADKSYGIHVAKIAGLPTDLLRRADAILTDLENQEKREASLPASRTD
SQKVSEQMSLFVEETENPVLTELRDLDIYNMTPLEVMAAVAELKKKL

Nucleotide

• Length: 2544 bp

>NTDB_id=350421 FOB91_RS06255 WP_012131025.1 1289886..1292429(-) (hexA) [Streptococcus gordonii strain FDAARGOS_683]
ATGGCAACAGAAAAAATATCGCCAGGTATGCAGCAGTACTTGGATATTAAAAAAGACTATCAGGACGCCTTCCTGCTGTT
TCGTATGGGTGATTTCTATGAGTTGTTTTACGAGGATGCTGTTAATGCGGCACAGATTCTCGAGATTGCCCTGACTAGCC
GTAATAAGAATTCAGAAAATCCCATTCCAATGGCGGGTGTACCTTATCACTCTGCCCAGCAATATATTGATGTTTTGATT
GAGTCTGGTTATAAGGTTGCCATTGCAGAGCAGATGGAAGATCCTAAACAGGCCGTGGGAGTGGTCAAACGCGAGGTGGT
CCAGGTTATTACGCCGGGTACGGTAGTGGATTCTAGTAAGCCAGTCGGAGAAAATAACTTTTTGGTTGCTTTGGATAGGC
AGGAGCAAGCTTATGGCTTGGCCTATATGGATCTGGCTACGGGAGAATTTCAGGTAACCAGCCTGGCAGACTTTGACCAA
GCTTGTGGAGAAATTCGAAATCTCCGAGCTCGGGAAGTAGTCGTAGGTTATTGCTTGTCAGAAGATGAGCAGCAGATTTT
GTCAAAACAAATGAATTTACTCCTGTCAGAAGTCGAGGAAGCAATGGAGGACGTTCAGCTTTTAGGAGATGAGTTGTCAT
CTTTAGAAAAGCAGACGGCAGGGAAGCTTCTGGCCTATGTTTTTCAGACACAGATGCGGGAGCTCAGCCATCTCAAGAAG
GTCCATCATTATGAGATAAAAGATTTTCTGCAGATGGATTATGCGACAAAGACCAGCCTAGACTTGACTGAAAATGCCCG
TACAGGTAAGAAGCATGGTAGTCTTTTTTGGCTCATGGATGAAACAAAAACGGCCATGGGAGGACGCCTACTTCGTTCTT
GGATCCAGCATCCCTTGATTGATAAGGGACGAATTATCAAGCGTCAAGATGTTGTTCAGGTCTTTCTGGATTATTTCTTT
GAGCGGAGTGATTTGGCAGATAGTCTCAAGGGCGTCTATGATATTGAACGCCTGGTAAGTCGTGTGTCATTTGGCAAGAC
CAATCCCAAGGACCTTCTACAATTGGCTTCTACTTTAAGCCATGTTCCTCAGATCCGGTCAATTTTAGAAACGATTGAAA
GCCCAGCTCTGGAGAGTTTGGTGGCAAGGCTAGATGCGATTCCTGAGCTGGAAAATCTAATCAGCTCTGCGATTGACCCA
GATGCTCCACAAGTAATTACTGAGGGCAATATCATTCGAACTGGTTTTGACGAGACTTTGGACCAGTACCGTTTGGTCAT
GAGAGAGGGGACTAGCTGGATTGCGGACATTGAAGCCAAGGAGCGAGAGGCAAGTGGTATTACTAATCTGAAAATTGATT
ATAACAAGAAGGATGGCTACTATTTCCATGTAACCAATTCTCAACTCGGCAATGTCCCTAGCCATTTTTTCCGAAAAGCA
ACCTTGAAAAATTCTGAGCGTTTTGGTACGGAAGAGCTGGCGCGCATTGAAGGCGAGATGTTGGAGGCGCGTGAGAAGTC
TGCTAATCTGGAATATGAGATCTTCATGCGCATTCGTGAAGAGGTCGGAAAATATATTCAACGGCTACAAGCCTTAGCTC
AAACCCTAGCTACGGTCGATGTTTTACAGAGCTTTGCGGTTGTGGCTGAAAGTCAACACTTAGTCCGTCCAAGTTTTACA
AGCAGTCGTAGTTTGCAGATTAAAAAAGGCCGTCATGCGGTTGTCGAAAAAGTCATGGGAGCCCAAAGCTACATCCCAAA
TAGTATCGAACTGGATCAAGAAACAGATATTCAGCTGATTACTGGACCAAATATGAGCGGGAAGTCAACCTACATGCGAC
AGCTGGCAATGATTGTCATCATGGCTCAAATGGGATCGTATGTACCAGCAGAAGTAGCCAGTCTTCCGATTTTCGATGCT
ATCTTTACACGAATAGGTGCGGCAGATGATTTGGTGTCTGGTCAATCGACCTTTATGGTGGAGATGATGGAGGCCAATCG
GGCCATTCGACAAGCAAGTGAACGCTCTTTGATCCTTTTTGATGAACTGGGGCGGGGGACTGCGACTTATGATGGGATGG
CTCTGGCACAAGCAATTATTGAGTATATTCATGATCGTACCAAGGCCAAGACTCTTTTTGCAACCCATTATCATGAGTTG
ACAGACCTGTCAAGTAGCTTGACACGATTAGAAAACGTCCATGTGGCAACTCTAGAAAAAGATGGCCAAGTGACATTTTT
ACATAAGATTGAAGCAGGACCTGCTGACAAGTCCTATGGGATTCATGTTGCAAAAATTGCTGGCTTACCTACGGATTTGT
TAAGGCGAGCAGATGCGATTTTGACAGATTTGGAAAATCAAGAGAAAAGAGAGGCTTCTCTTCCAGCGTCTAGAACGGAC
TCCCAAAAAGTGTCTGAGCAGATGTCGCTTTTTGTAGAAGAAACGGAAAATCCAGTCCTGACTGAACTACGAGACTTGGA
CATCTACAATATGACTCCCCTGGAAGTCATGGCAGCCGTGGCCGAGCTCAAGAAGAAGTTGTGA

Domains

Predicted by InterProScan.

• MutS family domain IV (MutS_IV) (415-505)

• MutS domain I (MutS_I) (8-118)

• MutS domain III (MutS_III) (256-546)

• MutS domain II (MutS_II) (126-239)

• MutS domain V (MutS_V) (599-785)

3D structure

• AlphaFold DB: A8AZU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	78.158	100	0.782
mutS	Pseudomonas stutzeri strain ATCC 17587	36.744	100	0.373