Detailed information NTG0349472

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EZ612_RS05805
• Genome accession: NZ_CP036531
• Coordinates: 1162799..1163836 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain STAB10048
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1157799..1168836

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EZ612_RS05785 (EZ612_05865)	-	1158531..1159157 (+)	627	WP_002983834.1	prepilin peptidase	-
EZ612_RS05790 (EZ612_05870)	rlmN	1159239..1160318 (-)	1080	WP_031488529.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
EZ612_RS05795 (EZ612_05875)	-	1160322..1160942 (-)	621	WP_002992791.1	YutD family protein	-
EZ612_RS05800 (EZ612_05880)	-	1161390..1162367 (-)	978	WP_031577505.1	LacI family DNA-binding transcriptional regulator	-
EZ612_RS05805 (EZ612_05885)	sepM	1162799..1163836 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
EZ612_RS05810 (EZ612_05890)	coaD	1163823..1164314 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
EZ612_RS05815 (EZ612_05895)	rsmD	1164304..1164843 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EZ612_RS05820 (EZ612_05900)	asnA	1164966..1165958 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
EZ612_RS05825 (EZ612_05905)	arcC	1166271..1167221 (-)	951	WP_010922501.1	carbamate kinase	-
EZ612_RS05830 (EZ612_05910)	-	1167241..1168572 (-)	1332	WP_030126384.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=349472 EZ612_RS05805 WP_010922499.1 1162799..1163836(-) (sepM) [Streptococcus pyogenes strain STAB10048]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=349472 EZ612_RS05805 WP_010922499.1 1162799..1163836(-) (sepM) [Streptococcus pyogenes strain STAB10048]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTATTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTCTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693