Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | EZ612_RS05450 | Genome accession | NZ_CP036531 |
| Coordinates | 1088413..1090218 (-) | Length | 601 a.a. |
| NCBI ID | WP_011054652.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain STAB10048 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1068182..1115232 | 1088413..1090218 | within | 0 |
Gene organization within MGE regions
Location: 1068182..1115232
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EZ612_RS05370 (EZ612_05445) | - | 1068220..1069494 (-) | 1275 | WP_020837316.1 | polysaccharide deacetylase family protein | - |
| EZ612_RS05375 (EZ612_05450) | - | 1069589..1071016 (-) | 1428 | WP_011284931.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| EZ612_RS05380 (EZ612_05455) | ptsP | 1071201..1072934 (-) | 1734 | WP_002984033.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| EZ612_RS05385 (EZ612_05460) | - | 1072939..1073202 (-) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| EZ612_RS05390 (EZ612_05465) | - | 1073595..1073813 (+) | 219 | WP_002989242.1 | redoxin NrdH | - |
| EZ612_RS05395 (EZ612_05470) | nrdE | 1073833..1075992 (+) | 2160 | WP_031488773.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| EZ612_RS05400 (EZ612_05475) | nrdF | 1076325..1077284 (+) | 960 | WP_002987365.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| EZ612_RS05405 (EZ612_05480) | - | 1077346..1078572 (+) | 1227 | WP_021340858.1 | chloride channel protein | - |
| EZ612_RS05410 (EZ612_05485) | - | 1078668..1079825 (+) | 1158 | Protein_1026 | IS3 family transposase | - |
| EZ612_RS05415 (EZ612_05490) | - | 1079917..1080612 (-) | 696 | WP_031488553.1 | CPBP family intramembrane glutamic endopeptidase | - |
| EZ612_RS05420 (EZ612_05495) | - | 1080631..1081392 (-) | 762 | WP_031488552.1 | DUF3169 family protein | - |
| EZ612_RS05425 (EZ612_05500) | - | 1081389..1081604 (-) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| EZ612_RS05430 (EZ612_05505) | alaS | 1081944..1084562 (-) | 2619 | WP_031488551.1 | alanine--tRNA ligase | - |
| EZ612_RS05435 (EZ612_05510) | prsA | 1084949..1086004 (-) | 1056 | WP_002984003.1 | peptidylprolyl isomerase PrsA | - |
| EZ612_RS05440 (EZ612_05515) | - | 1086067..1086774 (-) | 708 | WP_002984000.1 | O-methyltransferase | - |
| EZ612_RS05445 (EZ612_05520) | - | 1086840..1088036 (-) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| EZ612_RS05450 (EZ612_05525) | pepF | 1088413..1090218 (-) | 1806 | WP_011054652.1 | oligoendopeptidase F | Regulator |
| EZ612_RS05455 (EZ612_05530) | - | 1090231..1091193 (-) | 963 | WP_031488550.1 | competence protein CoiA | - |
| EZ612_RS05460 (EZ612_05535) | - | 1091489..1092205 (-) | 717 | WP_002995774.1 | pseudouridine synthase | - |
| EZ612_RS05465 (EZ612_05540) | nagB | 1092324..1093028 (-) | 705 | WP_002995779.1 | glucosamine-6-phosphate deaminase | - |
| EZ612_RS05470 (EZ612_05545) | queA | 1093230..1094258 (+) | 1029 | WP_031488549.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| EZ612_RS05475 (EZ612_05550) | - | 1094265..1095485 (+) | 1221 | WP_002983986.1 | DUF3114 domain-containing protein | - |
| EZ612_RS05480 (EZ612_05555) | - | 1095619..1096209 (-) | 591 | WP_002983984.1 | serine hydrolase | - |
| EZ612_RS08715 (EZ612_05560) | - | 1096206..1096433 (-) | 228 | WP_226316535.1 | hypothetical protein | - |
| EZ612_RS05490 (EZ612_05565) | - | 1096434..1096667 (-) | 234 | WP_002983979.1 | hypothetical protein | - |
| EZ612_RS05495 (EZ612_05570) | sodA | 1096834..1097439 (-) | 606 | WP_002983977.1 | superoxide dismutase SodA | - |
| EZ612_RS05500 (EZ612_05575) | holA | 1097536..1098576 (-) | 1041 | WP_031488548.1 | DNA polymerase III subunit delta | - |
| EZ612_RS05505 (EZ612_05580) | - | 1098647..1100890 (-) | 2244 | WP_031488547.1 | DNA internalization-related competence protein ComEC/Rec2 | - |
| EZ612_RS05510 (EZ612_05585) | - | 1100871..1101533 (-) | 663 | WP_002983967.1 | ComEA family DNA-binding protein | - |
| EZ612_RS05515 (EZ612_05590) | - | 1101733..1102473 (-) | 741 | WP_031488546.1 | lysophospholipid acyltransferase family protein | - |
| EZ612_RS05520 (EZ612_05595) | - | 1102591..1103367 (+) | 777 | WP_010922438.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| EZ612_RS05525 (EZ612_05600) | - | 1103357..1103635 (+) | 279 | WP_011017953.1 | GIY-YIG nuclease family protein | - |
| EZ612_RS05530 (EZ612_05605) | - | 1103659..1105659 (-) | 2001 | WP_031488545.1 | potassium transporter Kup | - |
| EZ612_RS05535 (EZ612_05610) | - | 1105786..1107405 (-) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| EZ612_RS05540 (EZ612_05615) | - | 1107712..1109256 (-) | 1545 | WP_031488544.1 | peptide chain release factor 3 | - |
| EZ612_RS05545 (EZ612_05625) | - | 1109504..1110199 (-) | 696 | WP_031488543.1 | TIGR02206 family membrane protein | - |
| EZ612_RS05550 (EZ612_05630) | - | 1110279..1111670 (-) | 1392 | WP_031488542.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| EZ612_RS05555 (EZ612_05635) | - | 1111861..1112907 (-) | 1047 | WP_002989146.1 | D-alanine--D-alanine ligase | - |
| EZ612_RS05560 (EZ612_05640) | recR | 1113008..1113604 (-) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| EZ612_RS08835 (EZ612_05645) | - | 1113651..1113842 (-) | 192 | WP_002983936.1 | hypothetical protein | - |
| EZ612_RS05570 (EZ612_05650) | - | 1114401..1115180 (-) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69341.19 Da Isoelectric Point: 4.7093
>NTDB_id=349469 EZ612_RS05450 WP_011054652.1 1088413..1090218(-) (pepF) [Streptococcus pyogenes strain STAB10048]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=349469 EZ612_RS05450 WP_011054652.1 1088413..1090218(-) (pepF) [Streptococcus pyogenes strain STAB10048]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
71.215 |
100 |
0.712 |