Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | EZY40_RS05450 | Genome accession | NZ_CP036530 |
| Coordinates | 1088180..1089985 (-) | Length | 601 a.a. |
| NCBI ID | WP_011054652.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain STAB09023 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1068079..1115019 | 1088180..1089985 | within | 0 |
Gene organization within MGE regions
Location: 1068079..1115019
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EZY40_RS05370 (EZY40_05445) | - | 1068117..1069391 (-) | 1275 | WP_020837316.1 | polysaccharide deacetylase family protein | - |
| EZY40_RS05375 (EZY40_05450) | - | 1069486..1070913 (-) | 1428 | WP_011284931.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| EZY40_RS05380 (EZY40_05455) | ptsP | 1071098..1072831 (-) | 1734 | WP_002984033.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| EZY40_RS05385 (EZY40_05460) | - | 1072836..1073099 (-) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| EZY40_RS05390 (EZY40_05465) | - | 1073492..1073710 (+) | 219 | WP_002989242.1 | redoxin NrdH | - |
| EZY40_RS05395 (EZY40_05470) | nrdE | 1073730..1075889 (+) | 2160 | WP_031488773.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| EZY40_RS05400 (EZY40_05475) | nrdF | 1076093..1077052 (+) | 960 | WP_002987365.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| EZY40_RS05405 (EZY40_05480) | - | 1077114..1078340 (+) | 1227 | WP_021340858.1 | chloride channel protein | - |
| EZY40_RS05410 (EZY40_05485) | - | 1078436..1079593 (+) | 1158 | Protein_1024 | IS3 family transposase | - |
| EZY40_RS05415 (EZY40_05490) | - | 1079685..1080380 (-) | 696 | WP_031488553.1 | CPBP family intramembrane glutamic endopeptidase | - |
| EZY40_RS05420 (EZY40_05495) | - | 1080399..1081160 (-) | 762 | WP_031488552.1 | DUF3169 family protein | - |
| EZY40_RS05425 (EZY40_05500) | - | 1081157..1081372 (-) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| EZY40_RS05430 (EZY40_05505) | alaS | 1081712..1084330 (-) | 2619 | WP_031488551.1 | alanine--tRNA ligase | - |
| EZY40_RS05435 (EZY40_05510) | prsA | 1084717..1085772 (-) | 1056 | WP_002984003.1 | peptidylprolyl isomerase PrsA | - |
| EZY40_RS05440 (EZY40_05515) | - | 1085835..1086542 (-) | 708 | WP_002984000.1 | O-methyltransferase | - |
| EZY40_RS05445 (EZY40_05520) | - | 1086608..1087804 (-) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| EZY40_RS05450 (EZY40_05525) | pepF | 1088180..1089985 (-) | 1806 | WP_011054652.1 | oligoendopeptidase F | Regulator |
| EZY40_RS05455 (EZY40_05530) | - | 1089998..1090960 (-) | 963 | WP_031488550.1 | competence protein CoiA | - |
| EZY40_RS05460 (EZY40_05535) | - | 1091256..1091972 (-) | 717 | WP_002995774.1 | pseudouridine synthase | - |
| EZY40_RS05465 (EZY40_05540) | nagB | 1092091..1092795 (-) | 705 | WP_002995779.1 | glucosamine-6-phosphate deaminase | - |
| EZY40_RS05470 (EZY40_05545) | queA | 1092997..1094025 (+) | 1029 | WP_031488549.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| EZY40_RS05475 (EZY40_05550) | - | 1094032..1095252 (+) | 1221 | WP_002983986.1 | DUF3114 domain-containing protein | - |
| EZY40_RS05480 (EZY40_05555) | - | 1095406..1095996 (-) | 591 | WP_154079612.1 | serine hydrolase | - |
| EZY40_RS08710 (EZY40_05560) | - | 1095993..1096220 (-) | 228 | WP_226316535.1 | hypothetical protein | - |
| EZY40_RS05490 (EZY40_05565) | - | 1096221..1096454 (-) | 234 | WP_002983979.1 | hypothetical protein | - |
| EZY40_RS05495 (EZY40_05570) | sodA | 1096621..1097226 (-) | 606 | WP_002983977.1 | superoxide dismutase SodA | - |
| EZY40_RS05500 (EZY40_05575) | holA | 1097323..1098363 (-) | 1041 | WP_031488548.1 | DNA polymerase III subunit delta | - |
| EZY40_RS05505 (EZY40_05580) | - | 1098434..1100677 (-) | 2244 | WP_031488547.1 | DNA internalization-related competence protein ComEC/Rec2 | - |
| EZY40_RS05510 (EZY40_05585) | - | 1100658..1101320 (-) | 663 | WP_002983967.1 | ComEA family DNA-binding protein | - |
| EZY40_RS05515 (EZY40_05590) | - | 1101520..1102260 (-) | 741 | WP_031488546.1 | lysophospholipid acyltransferase family protein | - |
| EZY40_RS05520 (EZY40_05595) | - | 1102378..1103154 (+) | 777 | WP_010922438.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| EZY40_RS05525 (EZY40_05600) | - | 1103144..1103422 (+) | 279 | WP_011017953.1 | GIY-YIG nuclease family protein | - |
| EZY40_RS05530 (EZY40_05605) | - | 1103446..1105446 (-) | 2001 | WP_031488545.1 | potassium transporter Kup | - |
| EZY40_RS05535 (EZY40_05610) | - | 1105573..1107192 (-) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| EZY40_RS05540 (EZY40_05615) | - | 1107499..1109043 (-) | 1545 | WP_031488544.1 | peptide chain release factor 3 | - |
| EZY40_RS05545 (EZY40_05625) | - | 1109291..1109986 (-) | 696 | WP_031488543.1 | TIGR02206 family membrane protein | - |
| EZY40_RS05550 (EZY40_05630) | - | 1110066..1111457 (-) | 1392 | WP_031488542.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| EZY40_RS05555 (EZY40_05635) | - | 1111648..1112694 (-) | 1047 | WP_156247240.1 | D-alanine--D-alanine ligase | - |
| EZY40_RS05560 (EZY40_05640) | recR | 1112795..1113391 (-) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| EZY40_RS08830 (EZY40_05645) | - | 1113438..1113629 (-) | 192 | WP_002983936.1 | hypothetical protein | - |
| EZY40_RS05570 (EZY40_05650) | - | 1114188..1114967 (-) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69341.19 Da Isoelectric Point: 4.7093
>NTDB_id=349417 EZY40_RS05450 WP_011054652.1 1088180..1089985(-) (pepF) [Streptococcus pyogenes strain STAB09023]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=349417 EZY40_RS05450 WP_011054652.1 1088180..1089985(-) (pepF) [Streptococcus pyogenes strain STAB09023]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
71.215 |
100 |
0.712 |