Detailed information    

insolico Bioinformatically predicted

Overview

Name   cqsS   Type   Regulator
Locus tag   EZZ25_RS16245 Genome accession   NZ_CP036500
Coordinates   423564..425624 (+) Length   686 a.a.
NCBI ID   WP_088124718.1    Uniprot ID   -
Organism   Vibrio cholerae strain 20000     
Function   autoinducer sensor (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 391646..423467 423564..425624 flank 97


Gene organization within MGE regions


Location: 391646..425624
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EZZ25_RS16060 (EZZ25_16060) - 391742..392659 (+) 918 WP_000186328.1 alpha/beta hydrolase -
  EZZ25_RS16065 (EZZ25_16065) - 392867..393109 (+) 243 WP_165490568.1 hypothetical protein -
  EZZ25_RS16070 (EZZ25_16070) - 393284..393673 (+) 390 WP_001081302.1 hypothetical protein -
  EZZ25_RS16075 (EZZ25_16075) - 393809..394234 (+) 426 WP_002045007.1 GNAT family N-acetyltransferase -
  EZZ25_RS16080 (EZZ25_16080) - 394409..394936 (+) 528 Protein_402 DUF3800 domain-containing protein -
  EZZ25_RS16090 (EZZ25_16090) - 396209..396556 (+) 348 Protein_404 DUF3800 domain-containing protein -
  EZZ25_RS16095 (EZZ25_16095) - 396706..397305 (+) 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
  EZZ25_RS16105 (EZZ25_16105) - 397592..397810 (+) 219 Protein_406 DUF3709 domain-containing protein -
  EZZ25_RS16110 (EZZ25_16110) - 398098..398634 (+) 537 WP_000469484.1 GNAT family protein -
  EZZ25_RS16120 (EZZ25_16120) - 399269..399538 (+) 270 WP_001114075.1 DUF4160 domain-containing protein -
  EZZ25_RS16125 (EZZ25_16125) - 399532..400053 (+) 522 WP_000921691.1 DUF2442 domain-containing protein -
  EZZ25_RS16130 (EZZ25_16130) - 400352..400477 (+) 126 WP_001905700.1 DUF645 family protein -
  EZZ25_RS16140 (EZZ25_16140) - 400728..401123 (+) 396 WP_001000868.1 hypothetical protein -
  EZZ25_RS16145 (EZZ25_16145) - 401262..401540 (-) 279 WP_000578471.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
  EZZ25_RS16150 (EZZ25_16150) - 401537..401821 (-) 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
  EZZ25_RS16155 (EZZ25_16155) - 402015..402530 (+) 516 WP_000343779.1 GNAT family protein -
  EZZ25_RS16165 (EZZ25_16165) - 402714..403127 (+) 414 WP_000049420.1 VOC family protein -
  EZZ25_RS16180 (EZZ25_16180) - 403682..404860 (+) 1179 Protein_416 IS3-like element ISVch4 family transposase -
  EZZ25_RS16185 (EZZ25_16185) - 405265..408051 (+) 2787 WP_001131704.1 alkaline phosphatase family protein -
  EZZ25_RS16190 (EZZ25_16190) nrdD 408514..410634 (+) 2121 WP_000802779.1 anaerobic ribonucleoside-triphosphate reductase -
  EZZ25_RS16195 (EZZ25_16195) nrdG 410639..411106 (+) 468 WP_001106198.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
  EZZ25_RS16200 (EZZ25_16200) - 411228..412409 (+) 1182 WP_000494047.1 amino acid aminotransferase -
  EZZ25_RS16205 (EZZ25_16205) - 412467..413150 (+) 684 WP_000082071.1 ATP-dependent zinc protease -
  EZZ25_RS16210 (EZZ25_16210) tnpA 413363..413800 (-) 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -
  EZZ25_RS16215 (EZZ25_16215) fruA 414006..415742 (-) 1737 WP_069503689.1 PTS fructose transporter subunit IIBC -
  EZZ25_RS16220 (EZZ25_16220) pfkB 415761..416714 (-) 954 WP_088124723.1 1-phosphofructokinase -
  EZZ25_RS16225 (EZZ25_16225) fruB 416725..417912 (-) 1188 WP_088124722.1 fused PTS fructose transporter subunit IIA/HPr protein -
  EZZ25_RS16230 (EZZ25_16230) cra 418251..419231 (+) 981 WP_088124721.1 catabolite repressor/activator -
  EZZ25_RS16235 (EZZ25_16235) - 419285..420424 (+) 1140 WP_088124720.1 exonuclease SbcCD subunit D -
  EZZ25_RS16240 (EZZ25_16240) - 420426..423467 (+) 3042 WP_088124719.1 SMC family ATPase -
  EZZ25_RS16245 (EZZ25_16245) cqsS 423564..425624 (+) 2061 WP_088124718.1 quorum-sensing CAI-1 autoinducer sensor kinase/phosphatase CqsS Regulator

Sequence

Protein


Download         Length: 686 a.a.        Molecular weight: 78383.15 Da        Isoelectric Point: 5.2930

>NTDB_id=349246 EZZ25_RS16245 WP_088124718.1 423564..425624(+) (cqsS) [Vibrio cholerae strain 20000]
MIVSMDVIKRVYQYAEPNLSLVGWMGMLGFPAYYFIWEYWFPQSYENLGLRCAAAVLFGGLVFRDSMPKKWQRYMPGYFL
FTIGFCLPFFFAFMMLMNDWSTIWAMSFMASIFLHILLVHDTRVMALQALFSVLVAYLAVYGLTDFHPTTLIEWQYIPIF
LFTYVFGNLCFFRNQISHETKVSIAKTFGAGIAHEMRNPLSALKTSIDVVRTMIPKPQTAAHTDYSLDAQELDLLHQILN
EADDVIYSGNNAIDLLLTSIDENRVSPASFKKHSVVDVIEKAVKTFPYKNAADQHSVELEVHQPFDFFGSDTLLTYALFN
LLKNAFYYQKEHFSVRISIEQTSEHNLIRVCDNGVGIAPEMLEDIFRDFYTFGKNGSYGLGLPFCRKVMSAFGGTIRCAS
QQGQWTEFVLSFPRYDSDTVNEIKTELLKTKSLIYIGSNQAIVRELNQLAVEDEFGFTAISAQQAVRRQDYEFEFDLILL
DLDDATAQGELLPKLEGTLSFAEGCIGYVYDPGKTYAVNINRYLRIQPISIHSILRKPRKIIERLLFEQESLSMNRNVIP
LQKSRHERRILVVDDNQSIRTFTAILLEQQGYEVVQANDGSEVLKHMESQNIDLVLMDIEMPNVGGLEATRLIRDSEHEY
KNIPIIGYTGDNSPKTLALVQTSGMNDFIVKPADRDVLLNKVAAWV

Nucleotide


Download         Length: 2061 bp        

>NTDB_id=349246 EZZ25_RS16245 WP_088124718.1 423564..425624(+) (cqsS) [Vibrio cholerae strain 20000]
GTGATAGTGAGCATGGATGTAATAAAGAGAGTGTATCAATACGCAGAACCTAATCTGTCCTTAGTCGGATGGATGGGCAT
GCTTGGCTTTCCTGCCTACTACTTCATCTGGGAATATTGGTTTCCGCAATCTTACGAAAATTTAGGGCTGCGTTGTGCGG
CAGCGGTGCTGTTTGGTGGGCTGGTGTTTCGTGATTCGATGCCTAAGAAATGGCAGCGGTATATGCCGGGCTATTTTCTA
TTCACCATAGGTTTCTGCTTACCCTTTTTCTTCGCTTTTATGATGTTAATGAACGACTGGTCGACAATTTGGGCCATGTC
GTTTATGGCGTCCATTTTTCTGCATATTCTCTTAGTGCACGATACGAGAGTGATGGCGTTACAAGCTCTTTTCTCAGTGT
TGGTGGCCTATCTTGCGGTATATGGTTTGACGGATTTTCACCCGACGACTTTGATTGAATGGCAATACATACCGATCTTT
TTGTTTACTTATGTATTTGGGAATTTATGTTTTTTCCGTAACCAAATTTCTCATGAGACCAAAGTGTCGATTGCCAAAAC
GTTCGGAGCGGGGATTGCCCATGAAATGCGTAATCCACTCAGCGCTTTGAAAACGTCGATTGATGTTGTGCGAACCATGA
TCCCTAAACCGCAAACTGCAGCTCATACGGATTATTCCTTGGATGCGCAAGAGCTGGATCTGCTGCATCAAATTTTGAAT
GAAGCTGATGATGTCATCTACTCTGGCAATAACGCGATTGATTTGCTGCTCACCTCGATTGATGAAAACCGTGTCTCTCC
GGCGAGTTTTAAAAAACACTCAGTGGTAGATGTGATTGAAAAAGCAGTGAAAACTTTTCCGTATAAAAATGCAGCGGACC
AGCACTCGGTAGAGCTTGAAGTGCATCAGCCGTTTGACTTTTTTGGCAGTGATACTCTACTGACTTATGCGCTATTTAAC
CTGTTGAAAAATGCCTTCTATTATCAAAAAGAGCATTTTTCAGTTCGTATTTCCATTGAACAAACCAGTGAGCATAACCT
TATTCGAGTCTGTGATAACGGCGTGGGGATTGCGCCAGAGATGTTGGAAGACATTTTCCGTGATTTCTATACCTTCGGTA
AAAATGGCAGCTATGGGCTAGGATTGCCATTTTGCCGCAAAGTGATGTCCGCATTTGGGGGGACGATTCGCTGTGCGTCT
CAACAAGGTCAATGGACAGAATTCGTATTGAGCTTTCCTCGTTACGATTCCGATACGGTTAACGAGATAAAAACAGAACT
GCTGAAAACCAAATCGCTCATTTATATCGGCTCAAATCAAGCTATCGTTCGAGAGTTAAATCAGCTCGCAGTAGAAGATG
AGTTTGGTTTTACCGCTATTTCTGCGCAGCAAGCTGTAAGACGCCAAGATTATGAGTTTGAGTTCGACCTTATTTTGCTC
GACCTTGATGACGCTACGGCGCAGGGAGAACTATTGCCGAAACTTGAAGGGACATTGAGTTTTGCAGAAGGCTGTATCGG
CTATGTGTATGATCCGGGCAAAACGTACGCAGTAAACATTAACCGTTATCTGCGCATCCAACCGATCAGTATTCATTCTA
TTCTCAGAAAGCCGCGGAAAATCATCGAACGCTTGTTGTTTGAGCAAGAATCCTTATCGATGAATCGTAACGTGATCCCC
TTGCAAAAGAGTCGGCATGAGCGACGTATTTTGGTGGTTGACGATAATCAATCGATCCGAACTTTTACGGCTATTTTGCT
TGAGCAACAAGGTTATGAAGTGGTGCAAGCCAACGATGGTAGTGAAGTGCTCAAGCATATGGAGAGTCAAAACATCGATT
TAGTGTTGATGGACATTGAAATGCCGAATGTCGGGGGATTAGAAGCGACGCGTTTAATTCGTGACTCTGAGCATGAGTAC
AAAAATATTCCGATCATTGGTTACACCGGTGATAACAGCCCCAAAACCTTGGCTCTGGTACAAACCTCTGGCATGAATGA
TTTCATTGTGAAGCCTGCTGACCGTGATGTATTGCTAAATAAAGTGGCAGCTTGGGTGTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(570-682)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(312-413)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cqsS Vibrio cholerae strain A1552

99.563

100

0.996

Multiple sequence alignment