Detailed information NTG0346769

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: EXW48_RS06200
• Genome accession: NZ_CP036101
• Coordinates: 1251226..1253826 (+)
• Length: 866 a.a.
• NCBI ID: WP_046958316.1
• Uniprot ID: A0A0G8CDV2
• Organism: Bacillus wiedmannii strain JAS28/2
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	1253967..1255427	1251226..1253826	flank	141

Gene organization within MGE regions

Location: 1251226..1255427

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EXW48_RS06200 (EXW48_06235)	clpC	1251226..1253826 (+)	2601	WP_046958316.1	ATP-dependent chaperone ClpB	Regulator
EXW48_RS06205 (EXW48_06240)	-	1253967..1255427 (+)	1461	WP_215561589.1	IS1182-like element ISBcy1 family transposase	-

Sequence

Protein

• Length: 866 a.a.
• Molecular weight: 97431.50 Da
• Isoelectric Point: 5.1540

>NTDB_id=346769 EXW48_RS06200 WP_046958316.1 1251226..1253826(+) (clpC) [Bacillus wiedmannii strain JAS28/2]
MDLNQMTTKTQEAIMSAQSLAVSHHHQEVDTVHLLFTLLEEQDGLAVRIFQKMNVDIEALKQGVESLIKKKPSVTGSGAE
VGKLYITGALQQLLVRAGKEAEKLQDDYISVEHVLLAFSEEKGDINQLLTRFHITKDNLLQSLMTVRGNQRVTSQNPEAT
YEALEKYGRDLVAEVRAGKIDPVIGRDSEIRRVIRILSRKTKNNPVLIGEPGVGKTAIVEGLAQRIVKKDVPEGLKDRTI
FALDMSALVAGAKFRGEFEERLQAVLNEIKKSEGRILLFIDELHTIVGAGKTEGAMDAGNMLKPMLARGELHCIGATTLD
EYRKYIEKDPALERRFQQVLAEEPTVEDTISILRGLKERFEIYHGVNIHDRAIVAASVLSDRYISDRFLPDKAIDLVDEA
CATIRTEIDSMPTELDEVTRRIMQLEIEEAALGKEKDFGSQERLKTLQLELSDLKEVASGMRAKWEKEKEDIHKVRDLRE
HLERLRRELEEAEGNYDLNKAAELRHGKIPAIEKELKEAEEMGAHNKQENRLLREEVSEEEIADIVSRWTGIPVAKLVEG
EREKLLRLEQILSERVIGQEEAVSLVSDAVLRARAGIKDPNRPIGSFIFLGPTGVGKTELAKTLAQSLFDSEEQMIRIDM
SEYMEKHAVSRLIGAPPGYVGYEEGGQLTEAVRRKPYSVILLDEIEKAHPEVFNILLQMLDDGRITDSQGRTVDFKNTVI
IMTSNIGSAHLLDGLEADGSIKEESRELVMGQLRGHFRPEFLNRVDEIILFKPLTTNEIKGIVDKIVKELQGRLADRHIT
VELTDAAREFVVEAGFDPMYGARPLKRYVQRQVETKLARELIAGTITDNSHVVVDVENNELVVHVK

Nucleotide

• Length: 2601 bp

>NTDB_id=346769 EXW48_RS06200 WP_046958316.1 1251226..1253826(+) (clpC) [Bacillus wiedmannii strain JAS28/2]
ATGGACTTAAATCAAATGACAACAAAAACACAAGAGGCGATTATGAGTGCCCAATCTTTAGCGGTATCTCATCATCATCA
AGAAGTAGATACTGTTCATCTCTTGTTTACATTATTAGAAGAGCAAGATGGGTTAGCAGTGCGTATTTTTCAAAAAATGA
ATGTCGATATAGAAGCGTTAAAGCAAGGCGTCGAAAGTTTAATTAAGAAAAAACCTTCTGTAACGGGAAGCGGTGCAGAA
GTAGGAAAATTATATATAACAGGTGCTCTGCAACAACTACTTGTAAGAGCAGGAAAAGAAGCAGAGAAATTGCAAGATGA
CTACATTTCAGTTGAACATGTATTGCTTGCTTTTTCAGAAGAAAAAGGCGATATAAATCAATTACTTACAAGATTTCACA
TTACGAAAGATAACTTATTACAGTCTTTAATGACAGTTCGGGGGAATCAAAGAGTGACTAGTCAAAATCCAGAAGCAACT
TATGAAGCGTTAGAAAAATATGGTCGTGATTTAGTGGCGGAAGTGAGAGCAGGGAAAATTGATCCTGTTATCGGTCGCGA
TAGTGAAATTCGACGTGTAATCCGCATTCTTTCACGTAAAACGAAAAACAACCCGGTTTTAATTGGTGAACCCGGTGTTG
GTAAAACAGCAATCGTTGAAGGATTAGCACAGCGTATTGTGAAGAAGGATGTACCAGAAGGATTAAAAGATAGAACAATC
TTCGCATTAGATATGAGTGCGCTTGTAGCTGGAGCGAAATTCCGTGGTGAGTTTGAAGAGCGTCTGCAAGCTGTATTAAA
TGAAATTAAAAAGAGTGAAGGTCGCATTTTATTATTCATTGATGAACTTCACACAATTGTCGGCGCTGGTAAAACAGAAG
GTGCGATGGACGCAGGAAATATGTTAAAACCGATGCTTGCGCGTGGTGAACTGCATTGTATCGGGGCGACAACGTTAGAT
GAGTATCGTAAATATATTGAGAAAGATCCAGCGCTAGAAAGACGTTTCCAACAAGTATTAGCAGAAGAACCAACTGTTGA
AGATACAATTTCCATTTTACGTGGTTTAAAAGAGCGCTTTGAAATTTATCATGGTGTAAATATTCATGACCGCGCGATTG
TAGCAGCATCCGTTTTATCAGATCGATATATTTCGGACCGTTTCTTACCAGATAAAGCGATTGATCTTGTTGACGAAGCG
TGCGCAACGATTCGAACAGAGATTGATTCTATGCCAACAGAATTAGATGAAGTAACGCGTCGTATTATGCAGCTGGAAAT
TGAAGAAGCGGCTCTTGGAAAAGAGAAGGACTTTGGTAGCCAAGAACGCCTGAAAACGTTGCAACTTGAATTGTCAGATT
TAAAAGAAGTTGCAAGTGGTATGAGAGCGAAATGGGAGAAAGAAAAAGAAGACATTCATAAAGTGCGTGACTTACGTGAA
CATTTAGAGCGCTTGCGCCGTGAGTTAGAAGAAGCAGAAGGAAATTACGATTTAAATAAAGCAGCTGAACTTCGTCACGG
GAAAATTCCAGCTATCGAAAAAGAGTTAAAAGAAGCGGAAGAAATGGGTGCACATAATAAACAAGAAAATCGTTTATTAC
GTGAGGAAGTAAGTGAAGAAGAGATTGCTGATATTGTTTCACGCTGGACTGGTATTCCTGTCGCGAAACTCGTTGAAGGT
GAACGCGAGAAATTACTACGCTTAGAGCAAATTTTATCAGAGCGTGTCATCGGACAAGAGGAAGCGGTAAGCTTAGTATC
AGACGCAGTTCTTCGTGCGCGCGCTGGTATTAAAGACCCGAACCGTCCAATTGGTTCCTTCATCTTTTTAGGACCGACAG
GTGTTGGTAAAACAGAACTTGCAAAAACGTTAGCACAGTCTTTATTCGATAGTGAAGAGCAAATGATTCGTATCGACATG
TCTGAGTATATGGAGAAACACGCTGTGTCACGCTTAATTGGTGCGCCTCCTGGATATGTTGGATATGAAGAGGGCGGTCA
ATTAACAGAAGCGGTAAGACGTAAACCGTATTCAGTTATTTTGTTAGACGAAATCGAAAAAGCACATCCAGAAGTATTCA
ACATTTTATTACAAATGTTAGATGATGGACGCATTACAGATTCTCAAGGACGTACAGTAGACTTTAAAAACACGGTTATT
ATTATGACTTCAAATATTGGATCTGCTCATTTGTTAGATGGATTAGAAGCAGATGGCTCAATTAAAGAGGAATCAAGAGA
ACTTGTAATGGGGCAATTAAGAGGACATTTCCGACCAGAGTTTTTAAACCGTGTCGATGAAATTATTTTATTCAAACCTC
TTACAACGAATGAAATTAAAGGTATTGTTGATAAAATTGTAAAAGAATTACAAGGTCGTTTAGCTGACCGTCATATTACA
GTAGAATTAACAGACGCAGCGAGAGAATTTGTTGTAGAAGCTGGCTTTGATCCGATGTACGGAGCTCGTCCATTAAAACG
ATATGTACAGCGTCAAGTTGAGACGAAATTAGCGAGAGAATTAATTGCAGGAACAATTACTGATAACAGTCACGTAGTTG
TTGATGTAGAAAATAACGAATTAGTCGTTCATGTAAAGTAA

Domains

Predicted by InterproScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (206-339)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (774-854)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (97-148)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (17-68)

• AAA lid domain (AAA_lid_9) (345-447)

• AAA domain (Cdc48 subfamily) (AAA_2) (602-768)

3D structure

• AlphaFold DB: A0A0G8CDV2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	47.657	100	0.482
clpC	Lactococcus lactis subsp. cremoris KW2	46.919	82.448	0.387
clpE	Streptococcus mutans UA159	46.016	84.065	0.387