Detailed information NTG0345221

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: GFB63_RS04670
• Genome accession: NZ_CP045596
• Coordinates: 903331..905889 (+)
• Length: 852 a.a.
• NCBI ID: WP_100273493.1
• Uniprot ID: -
• Organism: Streptococcus thermophilus strain TK-P3A
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 898331..910889

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GFB63_RS04645 (GFB63_04775)	-	898770..899096 (-)	327	Protein_903	transposase	-
GFB63_RS11135	-	899078..899215 (-)	138	WP_002948564.1	hypothetical protein	-
GFB63_RS04650 (GFB63_04780)	-	899542..901758 (+)	2217	WP_193838417.1	LPXTG cell wall anchor domain-containing protein	-
GFB63_RS04655 (GFB63_04785)	-	901853..902346 (-)	494	Protein_906	transposase	-
GFB63_RS04660 (GFB63_04790)	argR	902554..902979 (+)	426	WP_193838418.1	arginine repressor	-
GFB63_RS04665 (GFB63_04795)	-	902979..903338 (+)	360	WP_011225277.1	YlbF family regulator	-
GFB63_RS04670 (GFB63_04800)	hexA	903331..905889 (+)	2559	WP_100273493.1	DNA mismatch repair protein MutS	Machinery gene
GFB63_RS04675 (GFB63_04805)	-	905923..906378 (-)	456	WP_084825708.1	DUF3021 domain-containing protein	-
GFB63_RS04680 (GFB63_04810)	-	906375..906812 (-)	438	WP_002886318.1	LytTR family DNA-binding domain-containing protein	-
GFB63_RS04685 (GFB63_04815)	-	906991..907296 (+)	306	WP_084830425.1	hypothetical protein	-
GFB63_RS04690 (GFB63_04820)	hexB	907348..909291 (+)	1944	WP_011680601.1	DNA mismatch repair endonuclease MutL	Machinery gene
GFB63_RS04695 (GFB63_04825)	-	909422..909643 (+)	222	WP_011680602.1	hypothetical protein	-
GFB63_RS04700 (GFB63_04830)	ruvA	909795..910385 (+)	591	WP_111679083.1	Holliday junction branch migration protein RuvA	Machinery gene

Sequence

Protein

• Length: 852 a.a.
• Molecular weight: 95411.66 Da
• Isoelectric Point: 4.6669

>NTDB_id=345221 GFB63_RS04670 WP_100273493.1 903331..905889(+) (hexA) [Streptococcus thermophilus strain TK-P3A]
MAKEKISPGMQQYLDIKKNYPDAFLLFRMGDFYELFYDDAVKAAQILEISLTSRNKNADNPIPMAGVPYHSAQAYIDVLV
EMGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSANNFLVAIDKVGSRFGLSYMDVSTGEFFATELDDFSS
VCSEIQNLKAREVVVGYDLLETDEQVLVNQLNLLLSKETEGYDDVHLIGNSLTDLESSVASKLLQYVHRTQMRELSHLQK
AQHYEIKDYLQMSYATKSSLDLLENARTGKKHGSLFWLLDETKTAMGMRLLRTWIDRPLVNQATIIERQNIIQVFLDNFF
ERSDLTESLKGVYDIERLASRVSFGKANPKDLIQLGHTLAQVPVIKAILESFNDDALSGLLQELDALPELESLILSAIDP
DAPATITEGGIIRDGFDDTLDKYRKVMSEGTSWIADIEAKEREASGITTLKIDYNRKDGYYFHVTNSNLSLVPDHFFRKA
TLKNSERFGTAELAKIEGEMLEAREKSSTLEYDIFMRVREQVERYIDRLQSLAKVIATVDVLQSLAVTAETNHYVRPVFN
DEHRITIDQGRHAVVEKVMGVQEYIPNTITFDSQTNIQLITGPNMSGKSTYMRQLALSVVMAQMGAYIPADSVDLPIFDA
IYTRIGAADDLISGQSTFMVEMMEANQAIKRATPNSLIIFDELGRGTATYDGMALAQSIIEFIHDKVGAKTMFATHYHEL
TALSNSLTHLVNVHVATLEKDGEVTFLHKIVDGPADKSYGIHVAKIAGLPIDLLNRADTILTQLEGETVVIQPQEKVSSQ
EKPAIETHVNEQISLFGDFTENPVLQELRDLDIYNMTPMQVMMAVADLKQKL

Nucleotide

• Length: 2559 bp

>NTDB_id=345221 GFB63_RS04670 WP_100273493.1 903331..905889(+) (hexA) [Streptococcus thermophilus strain TK-P3A]
ATGGCTAAGGAAAAAATATCTCCAGGAATGCAGCAGTATTTGGATATCAAGAAAAATTATCCAGATGCTTTTTTGCTGTT
TCGGATGGGGGATTTTTACGAATTATTTTACGATGATGCTGTTAAGGCTGCCCAGATTTTGGAAATTAGCCTAACTAGCC
GTAATAAGAATGCAGATAATCCCATTCCTATGGCAGGTGTGCCTTATCATTCAGCTCAAGCATACATTGATGTTTTGGTT
GAGATGGGCTACAAGGTAGCCATTGCTGAGCAGATGGAGGATCCTAAGCAGGCTGTCGGTGTGGTGAAGCGTGAGGTTGT
TCAGGTTATCACACCAGGTACAGTGGTTGACAGCTCTAAACCTGATAGTGCCAACAATTTCTTGGTGGCCATTGACAAGG
TTGGAAGTCGTTTTGGTCTTTCCTATATGGATGTGTCAACGGGTGAATTTTTTGCGACAGAGTTGGATGATTTTAGTTCA
GTTTGTAGTGAAATTCAGAACCTTAAGGCACGTGAAGTAGTGGTTGGATATGATCTACTTGAAACTGACGAACAAGTTTT
AGTGAACCAACTTAACCTACTTCTCTCCAAGGAAACAGAAGGTTACGATGATGTTCACTTGATTGGTAATAGCTTGACAG
ATTTGGAAAGCAGTGTGGCAAGTAAACTTCTCCAGTATGTTCATCGCACTCAGATGCGTGAGCTCAGTCATTTACAAAAA
GCTCAGCACTATGAGATAAAGGATTACTTGCAGATGTCCTATGCGACCAAGTCAAGCTTGGATTTACTGGAAAATGCTAG
AACGGGCAAGAAACACGGTTCTCTTTTCTGGCTCTTGGATGAAACCAAGACAGCCATGGGAATGCGTCTCTTGCGAACTT
GGATTGATCGGCCTTTAGTGAATCAAGCCACCATCATAGAGCGTCAGAATATTATCCAAGTTTTCTTGGACAATTTCTTT
GAGCGTAGTGACTTGACCGAGAGTCTAAAAGGTGTTTACGATATTGAGCGTCTGGCCAGTCGTGTTTCCTTTGGCAAGGC
TAATCCTAAAGATTTAATTCAGCTAGGTCATACCTTAGCTCAGGTTCCGGTCATTAAGGCAATCTTGGAGTCCTTTAATG
ACGATGCCTTGTCAGGTCTTTTACAAGAGTTAGATGCTTTGCCAGAATTAGAGAGTTTGATTCTTTCGGCTATTGATCCT
GATGCTCCAGCAACAATTACAGAAGGTGGTATTATCCGTGATGGTTTTGATGATACCTTGGACAAGTATCGCAAAGTGAT
GAGCGAGGGGACGTCATGGATTGCGGATATCGAAGCCAAAGAACGTGAAGCGTCTGGTATTACAACACTAAAAATTGATT
ATAACCGTAAAGATGGTTATTACTTCCATGTGACCAACTCTAACCTTAGCTTGGTTCCTGACCATTTCTTCCGTAAGGCA
ACACTGAAAAATTCGGAGCGTTTTGGAACTGCTGAGTTGGCTAAGATTGAAGGTGAAATGCTAGAAGCGCGTGAAAAATC
GTCAACCCTAGAGTATGATATTTTCATGCGTGTCCGTGAGCAAGTTGAACGCTATATCGACCGTTTGCAGTCTTTGGCTA
AGGTCATTGCGACAGTTGATGTGCTTCAGAGTTTGGCTGTTACAGCGGAGACAAATCATTATGTTCGTCCTGTTTTTAAT
GATGAGCATCGTATCACTATTGATCAGGGCCGTCATGCGGTGGTTGAGAAGGTTATGGGCGTTCAGGAATACATTCCAAA
TACGATTACCTTTGACAGTCAGACCAATATTCAGCTCATCACAGGACCAAATATGAGTGGTAAATCTACCTATATGCGGC
AGTTAGCCTTGTCAGTAGTTATGGCTCAAATGGGGGCTTACATACCAGCAGATAGTGTTGATTTACCAATTTTTGACGCT
ATCTATACACGTATAGGTGCCGCAGATGACCTGATTTCAGGTCAGTCGACCTTCATGGTTGAGATGATGGAGGCTAATCA
GGCCATTAAGCGAGCGACACCTAATTCCTTGATTATTTTTGATGAGTTGGGGCGTGGGACAGCCACTTATGATGGTATGG
CTTTGGCCCAGTCTATTATTGAGTTTATTCATGACAAGGTGGGGGCTAAGACCATGTTTGCTACCCATTATCATGAGTTG
ACTGCGCTGTCAAACAGTTTGACACACCTTGTCAACGTCCATGTTGCGACACTTGAAAAGGATGGCGAAGTGACTTTCCT
CCACAAAATTGTCGATGGTCCAGCTGATAAATCTTATGGTATTCATGTAGCTAAAATTGCAGGTTTACCAATAGATTTAT
TGAACCGTGCTGACACCATATTGACACAATTAGAAGGAGAGACAGTTGTAATCCAACCTCAGGAAAAGGTATCGTCTCAA
GAAAAGCCTGCCATTGAAACGCATGTCAACGAGCAAATCTCTCTCTTTGGTGACTTTACTGAAAATCCAGTTCTTCAAGA
GTTGCGTGATTTGGACATTTACAACATGACACCGATGCAAGTCATGATGGCTGTAGCAGATTTAAAACAGAAACTATAA

Domains

Predicted by InterProScan.

• MutS domain III (MutS_III) (256-546)

• MutS domain I (MutS_I) (8-118)

• MutS domain V (MutS_V) (599-785)

• MutS domain II (MutS_II) (126-239)

• MutS family domain IV (MutS_IV) (415-505)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	73.826	100	0.738
mutS	Pseudomonas stutzeri strain ATCC 17587	35.903	100	0.366