Detailed information NTG0344421

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ERW13_RS00485
• Genome accession: NZ_CP035791
• Coordinates: 81584..82627 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 592
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76584..87627

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ERW13_RS00445	-	77010..77120 (+)	111	WP_001790257.1	hypothetical protein	-
ERW13_RS00450	-	77149..77562 (+)	414	WP_001557448.1	hypothetical protein	-
ERW13_RS00460	-	77993..78979 (-)	987	WP_000999717.1	aromatic acid exporter family protein	-
ERW13_RS00470	map	79510..80268 (+)	759	WP_000636140.1	type I methionyl aminopeptidase	-
ERW13_RS00475	-	80485..80871 (+)	387	WP_001110179.1	hypothetical protein	-
ERW13_RS00480	liaF	80886..81587 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ERW13_RS00485	vraS	81584..82627 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ERW13_RS00490	vraR	82617..83246 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ERW13_RS00495	-	83359..84576 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
ERW13_RS00500	-	84854..85129 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ERW13_RS00505	-	85136..85600 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ERW13_RS00510	-	85747..85947 (+)	201	WP_000180460.1	DUF1128 family protein	-
ERW13_RS00515	-	85950..87206 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=344421 ERW13_RS00485 WP_001017131.1 81584..82627(+) (vraS) [Staphylococcus aureus strain 592]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=344421 ERW13_RS00485 WP_001017131.1 81584..82627(+) (vraS) [Staphylococcus aureus strain 592]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1