Detailed information NTG0343487

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: EWG56_RS12615
• Genome accession: NZ_CP035671
• Coordinates: 2470532..2471575 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain VB31683
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2465532..2476575

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EWG56_RS12580 (EWG56_12580)	-	2465960..2466070 (+)	111	WP_001790257.1	hypothetical protein	-
EWG56_RS12585 (EWG56_12585)	-	2466099..2466512 (+)	414	WP_001670387.1	hypothetical protein	-
EWG56_RS12595 (EWG56_12595)	-	2466943..2467929 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
EWG56_RS12600 (EWG56_12600)	map	2468458..2469216 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
EWG56_RS12605 (EWG56_12605)	-	2469433..2469819 (+)	387	WP_001110179.1	hypothetical protein	-
EWG56_RS12610 (EWG56_12610)	liaF	2469834..2470535 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
EWG56_RS12615 (EWG56_12615)	vraS	2470532..2471575 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
EWG56_RS12620 (EWG56_12620)	vraR	2471565..2472194 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
EWG56_RS12625 (EWG56_12625)	-	2472307..2473524 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
EWG56_RS12630 (EWG56_12630)	-	2473802..2474077 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
EWG56_RS12635 (EWG56_12635)	-	2474084..2474548 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
EWG56_RS12640 (EWG56_12640)	-	2474695..2474895 (+)	201	WP_000180460.1	DUF1128 family protein	-
EWG56_RS12645 (EWG56_12645)	-	2474898..2476154 (+)	1257	WP_075583716.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=343487 EWG56_RS12615 WP_001017131.1 2470532..2471575(+) (vraS) [Staphylococcus aureus strain VB31683]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=343487 EWG56_RS12615 WP_001017131.1 2470532..2471575(+) (vraS) [Staphylococcus aureus strain VB31683]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1