Detailed information NTG0342427

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: ETT46_RS08830
• Genome accession: NZ_CP035453
• Coordinates: 1713561..1716005 (-)
• Length: 814 a.a.
• NCBI ID: WP_136265062.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm100
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1708561..1721005

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT46_RS08805 (ETT46_08800)	-	1708686..1710185 (+)	1500	WP_014407906.1	C69 family dipeptidase	-
ETT46_RS09715	-	1710509..1710862 (+)	354	Protein_1649	NUDIX domain-containing protein	-
ETT46_RS08815 (ETT46_08810)	-	1710848..1711175 (-)	328	Protein_1650	helix-turn-helix domain-containing protein	-
ETT46_RS08820 (ETT46_08815)	groL	1711426..1713057 (-)	1632	WP_002982320.1	chaperonin GroEL	-
ETT46_RS08825 (ETT46_08820)	groES	1713093..1713383 (-)	291	WP_002991292.1	co-chaperone GroES	-
ETT46_RS08830 (ETT46_08825)	clpC	1713561..1716005 (-)	2445	WP_136265062.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
ETT46_RS08835 (ETT46_08830)	-	1716005..1716466 (-)	462	WP_002982312.1	CtsR family transcriptional regulator	-
ETT46_RS08840 (ETT46_08835)	-	1716662..1716865 (-)	204	WP_002991299.1	cold-shock protein	-
ETT46_RS08850 (ETT46_08845)	ahpC	1717849..1718409 (+)	561	WP_002982304.1	alkyl hydroperoxide reductase subunit C	-
ETT46_RS08855 (ETT46_08850)	ahpF	1718430..1719962 (+)	1533	WP_110002696.1	alkyl hydroperoxide reductase subunit F	-

Sequence

Protein

• Length: 814 a.a.
• Molecular weight: 90678.42 Da
• Isoelectric Point: 6.8888

>NTDB_id=342427 ETT46_RS08830 WP_136265062.1 1713561..1716005(-) (clpC) [Streptococcus pyogenes strain emm100]
MIMYSTKMQDIFRQAQFQAARFDSHCLETWHVLLAMVAVDNSLANMILSEYDAQVAIEEYEAAAILAMGKTPKEQLSRVD
FRPQSKTLTNLLAFAQAISQITRDQEVGSEHVLFAILLNPDIMASRLLEIAGYQIKDSGNGQPRLADLRKAIERHAGYSK
EMIKAIHELRKPKKTKTQGTFSDMMKPPSTAGELSDFTRDLTEMARQGLLESVIGRDQEVSRMIQVLSRKTKNNPVLVGD
AGVGKTALAYGLAQRIANGAIPYELKEMRVLELDMMSVVAGTRFRGDFEERMNQIIDDIEADDQIILFVDELHTIMGSGS
GIDSTLDAANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKILIEEPNAEDAYQILMGLKLSYETYHNVSISN
EAVKIAVKMAHRYLTSKNLPDSAIDLLDEASAAVQNMVKKSAPETLTPIDQALINGDMKKVSRLLAKEAKGQMRKPTPVT
EDDILATLSKLSGIPLEKLTQADSKKYLNLEKELHKRVIGQDAAVTAISRAIRRNHSGIRTGKRPIGSFMFLGPTGVGKT
ELAKALAEVLFDDEAALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTQKVRNKPYSVLLFDEVEKAHPDIFNVLLQ
VLDDGILTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGVKGIHQDHQAMEKRILEELRKTYRPEFINRIDEKVVFH
SLTQDNMRDVVKIMVQPLITTLAEKGITLKIQPLALKHLSEVGYDEHMGARPLRRTLQTEIEDKLSELILSRELTSGHTL
KIGLSHGKLTFHIA

Nucleotide

• Length: 2445 bp

>NTDB_id=342427 ETT46_RS08830 WP_136265062.1 1713561..1716005(-) (clpC) [Streptococcus pyogenes strain emm100]
ATGATTATGTATTCAACGAAGATGCAAGACATTTTTAGACAGGCGCAGTTCCAAGCTGCTCGCTTTGATAGCCACTGCCT
GGAAACTTGGCATGTTTTGTTAGCTATGGTAGCTGTAGACAATTCTTTAGCAAATATGATTTTAAGTGAATATGATGCCC
AAGTCGCCATAGAAGAATATGAAGCTGCAGCTATTTTAGCCATGGGCAAAACCCCTAAGGAACAGTTGTCTCGTGTAGAC
TTCAGACCTCAATCTAAAACTTTGACTAACTTGTTAGCTTTTGCGCAGGCTATTAGCCAAATCACTAGGGATCAAGAAGT
CGGCTCTGAGCATGTCTTATTTGCTATTTTATTGAATCCAGATATTATGGCGAGTCGCTTGTTAGAAATAGCAGGCTATC
AGATAAAAGATAGCGGCAATGGGCAGCCGCGATTAGCTGACTTACGAAAAGCAATAGAACGTCATGCAGGTTACAGTAAG
GAAATGATCAAGGCTATTCACGAACTACGTAAGCCTAAAAAAACGAAAACACAAGGGACCTTTTCAGATATGATGAAGCC
ACCAAGTACAGCTGGTGAGTTGAGTGATTTCACAAGAGATTTGACTGAAATGGCAAGACAAGGTTTGTTAGAATCGGTGA
TTGGACGTGACCAAGAAGTATCTCGTATGATTCAGGTATTAAGTCGTAAAACGAAAAACAATCCTGTCTTGGTAGGTGAT
GCAGGTGTTGGTAAAACTGCGCTTGCTTATGGCCTTGCTCAACGGATTGCAAATGGCGCTATTCCTTATGAACTTAAGGA
GATGCGTGTCCTAGAATTAGACATGATGAGTGTGGTAGCAGGAACCCGTTTTCGTGGGGATTTTGAAGAGCGCATGAATC
AAATCATTGATGATATTGAAGCTGATGATCAGATTATTCTTTTTGTTGATGAACTACATACTATTATGGGTTCTGGCAGT
GGTATTGACAGTACACTTGATGCGGCTAACATTTTAAAACCAGCATTATCGCGCGGCACTCTTCATATGGTTGGAGCAAC
AACTCAAGAAGAATATCAAAAACATATTGAAAAAGATGCAGCTCTTTCGCGTCGTTTTGCTAAAATATTAATTGAAGAAC
CTAATGCAGAAGACGCTTATCAGATTTTGATGGGCCTAAAATTATCTTATGAGACCTACCATAATGTCTCGATATCAAAT
GAAGCAGTTAAAATAGCTGTAAAAATGGCACACCGTTATTTAACCAGTAAAAATCTCCCTGATTCAGCTATCGATTTATT
AGATGAAGCTAGTGCTGCTGTGCAAAACATGGTGAAAAAATCAGCACCTGAGACTTTAACACCAATAGACCAAGCTCTTA
TCAATGGTGATATGAAAAAAGTATCTCGCCTCTTAGCTAAAGAAGCAAAAGGTCAGATGAGAAAACCAACACCAGTGACA
GAAGATGATATTTTGGCAACCTTGAGTAAGTTATCGGGAATTCCACTTGAAAAACTGACGCAAGCTGATAGTAAAAAATA
CCTCAATTTAGAAAAAGAACTGCATAAGCGTGTGATTGGTCAGGATGCTGCTGTTACGGCTATTTCAAGAGCCATTCGTC
GCAATCATTCAGGTATTCGAACAGGAAAACGTCCTATTGGATCATTTATGTTTCTTGGCCCAACAGGAGTAGGTAAGACA
GAACTAGCAAAGGCCCTTGCAGAAGTTCTCTTTGATGATGAAGCAGCGCTTATTCGTTTTGATATGTCTGAGTACATGGA
AAAATTCGCAGCGTCTAGGCTTAATGGAGCACCTCCTGGTTATGTCGGCTATGATGAAGGAGGTGAACTGACACAGAAAG
TTAGAAATAAACCTTATTCAGTCTTGCTTTTTGATGAAGTGGAAAAAGCACATCCTGATATTTTTAACGTTCTCCTTCAA
GTATTAGATGATGGTATATTGACTGATAGTCGTGGGCGTAAGGTCGATTTTTCAAATACTATTATTATCATGACCAGCAA
TCTTGGCGCAACAGCCCTGCGTGATGATAAAACGGTCGGTTTTGGGGTCAAAGGCATTCACCAAGACCATCAAGCTATGG
AGAAACGTATTTTAGAAGAATTAAGAAAAACTTACCGCCCAGAATTTATCAATCGTATTGATGAAAAAGTGGTCTTTCAT
AGTCTGACCCAAGATAACATGCGCGATGTGGTTAAAATCATGGTACAGCCCCTGATTACTACATTGGCAGAAAAAGGTAT
TACCCTTAAAATTCAGCCTTTGGCCTTGAAACATTTGTCCGAGGTCGGCTATGATGAGCATATGGGGGCAAGACCATTAC
GTCGAACGCTGCAAACTGAGATAGAAGATAAGCTATCAGAGCTTATTCTTTCTCGAGAATTGACAAGTGGGCATACGCTA
AAAATTGGATTATCACATGGCAAATTAACGTTTCACATAGCTTAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (544-715)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (722-801)

• ATPase family associated with various cellular activities (AAA) (AAA) (236-368)

• AAA lid domain (AAA_lid_9) (376-459)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-130)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus mutans UA159	74.908	99.877	0.748
clpC	Streptococcus thermophilus LMG 18311	70.956	100	0.711
clpC	Streptococcus thermophilus LMD-9	70.833	100	0.71
clpC	Streptococcus pneumoniae TIGR4	65.602	100	0.656
clpC	Streptococcus pneumoniae Rx1	65.602	100	0.656
clpC	Streptococcus pneumoniae D39	65.602	100	0.656
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	47.852	100	0.493
clpC	Bacillus subtilis subsp. subtilis str. 168	42.086	100	0.431