Detailed information NTG0342417

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ETT46_RS06600
• Genome accession: NZ_CP035453
• Coordinates: 1255217..1256254 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain emm100
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1250217..1261254

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT46_RS06575 (ETT46_06570)	-	1250221..1250748 (-)	528	WP_014635585.1	Dps family protein	-
ETT46_RS06580 (ETT46_06575)	-	1250976..1251602 (+)	627	WP_002989076.1	A24 family peptidase	-
ETT46_RS06585 (ETT46_06580)	rlmN	1251684..1252763 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ETT46_RS06590 (ETT46_06585)	-	1252767..1253387 (-)	621	WP_002992791.1	YutD family protein	-
ETT46_RS06595 (ETT46_06590)	-	1253835..1254812 (-)	978	WP_136038668.1	LacI family DNA-binding transcriptional regulator	-
ETT46_RS06600 (ETT46_06595)	sepM	1255217..1256254 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ETT46_RS06605 (ETT46_06600)	coaD	1256241..1256732 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ETT46_RS06610 (ETT46_06605)	rsmD	1256722..1257261 (-)	540	WP_136098787.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ETT46_RS06615 (ETT46_06610)	asnA	1257384..1258376 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
ETT46_RS06620 (ETT46_06615)	arcC	1258689..1259639 (-)	951	WP_010922501.1	carbamate kinase	-
ETT46_RS06625 (ETT46_06620)	-	1259659..1260990 (-)	1332	WP_011054719.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=342417 ETT46_RS06600 WP_010922499.1 1255217..1256254(-) (sepM) [Streptococcus pyogenes strain emm100]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=342417 ETT46_RS06600 WP_010922499.1 1255217..1256254(-) (sepM) [Streptococcus pyogenes strain emm100]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693