Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | ETT46_RS05985 | Genome accession | NZ_CP035453 |
| Coordinates | 1147223..1149028 (-) | Length | 601 a.a. |
| NCBI ID | WP_136265167.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain emm100 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1126974..1174022 | 1147223..1149028 | within | 0 |
Gene organization within MGE regions
Location: 1126974..1174022
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ETT46_RS05905 (ETT46_05900) | - | 1127012..1128286 (-) | 1275 | WP_020837316.1 | polysaccharide deacetylase family protein | - |
| ETT46_RS05910 (ETT46_05905) | - | 1128381..1129808 (-) | 1428 | WP_011284931.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| ETT46_RS05915 (ETT46_05910) | ptsP | 1129993..1131726 (-) | 1734 | WP_020837320.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| ETT46_RS05920 (ETT46_05915) | - | 1131731..1131994 (-) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| ETT46_RS05925 (ETT46_05920) | - | 1132387..1132605 (+) | 219 | WP_002989242.1 | redoxin NrdH | - |
| ETT46_RS05930 (ETT46_05925) | nrdE | 1132625..1134784 (+) | 2160 | WP_136265279.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| ETT46_RS05935 (ETT46_05930) | nrdF | 1135117..1136076 (+) | 960 | WP_002987365.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| ETT46_RS05940 (ETT46_05935) | - | 1136138..1137364 (+) | 1227 | WP_014635559.1 | chloride channel protein | - |
| ETT46_RS05945 (ETT46_05940) | - | 1137460..1138616 (+) | 1157 | Protein_1112 | IS3 family transposase | - |
| ETT46_RS05950 (ETT46_05945) | - | 1138708..1139403 (-) | 696 | WP_136265163.1 | CPBP family intramembrane glutamic endopeptidase | - |
| ETT46_RS05955 (ETT46_05950) | - | 1139422..1140183 (-) | 762 | WP_136048075.1 | DUF3169 family protein | - |
| ETT46_RS05960 (ETT46_05955) | - | 1140180..1140395 (-) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| ETT46_RS05965 (ETT46_05960) | alaS | 1140755..1143373 (-) | 2619 | WP_136048074.1 | alanine--tRNA ligase | - |
| ETT46_RS05970 (ETT46_05965) | prsA | 1143760..1144815 (-) | 1056 | WP_002984003.1 | peptidylprolyl isomerase PrsA | - |
| ETT46_RS05975 (ETT46_05970) | - | 1144878..1145585 (-) | 708 | WP_002984000.1 | O-methyltransferase | - |
| ETT46_RS05980 (ETT46_05975) | - | 1145651..1146847 (-) | 1197 | WP_115224998.1 | OFA family MFS transporter | - |
| ETT46_RS05985 (ETT46_05980) | pepF | 1147223..1149028 (-) | 1806 | WP_136265167.1 | oligoendopeptidase F | Regulator |
| ETT46_RS05990 (ETT46_05985) | - | 1149041..1150003 (-) | 963 | WP_002983995.1 | competence protein CoiA | - |
| ETT46_RS05995 (ETT46_05990) | - | 1150298..1151014 (-) | 717 | WP_136265169.1 | pseudouridine synthase | - |
| ETT46_RS06000 (ETT46_05995) | nagB | 1151133..1151837 (-) | 705 | WP_009880651.1 | glucosamine-6-phosphate deaminase | - |
| ETT46_RS06005 (ETT46_06000) | queA | 1152039..1153067 (+) | 1029 | WP_136075214.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| ETT46_RS06010 (ETT46_06005) | - | 1153074..1154294 (+) | 1221 | WP_136075215.1 | DUF3114 domain-containing protein | - |
| ETT46_RS06015 (ETT46_06010) | - | 1154408..1154998 (-) | 591 | WP_002983984.1 | serine hydrolase | - |
| ETT46_RS06020 (ETT46_06015) | - | 1154995..1155243 (-) | 249 | WP_011054656.1 | hypothetical protein | - |
| ETT46_RS06025 (ETT46_06020) | - | 1155228..1155455 (-) | 228 | WP_011054657.1 | hypothetical protein | - |
| ETT46_RS06030 (ETT46_06025) | sodA | 1155622..1156227 (-) | 606 | WP_002983977.1 | superoxide dismutase SodA | - |
| ETT46_RS06035 (ETT46_06030) | holA | 1156324..1157364 (-) | 1041 | WP_136110881.1 | DNA polymerase III subunit delta | - |
| ETT46_RS06040 (ETT46_06035) | - | 1157435..1159678 (-) | 2244 | WP_136265171.1 | DNA internalization-related competence protein ComEC/Rec2 | - |
| ETT46_RS06045 (ETT46_06040) | - | 1159659..1160321 (-) | 663 | WP_136110879.1 | ComEA family DNA-binding protein | - |
| ETT46_RS06050 (ETT46_06045) | - | 1160521..1161261 (-) | 741 | WP_011054661.1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase | - |
| ETT46_RS06055 (ETT46_06050) | - | 1161379..1162155 (+) | 777 | WP_136265173.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| ETT46_RS06060 (ETT46_06055) | - | 1162145..1162423 (+) | 279 | WP_002989164.1 | GIY-YIG nuclease family protein | - |
| ETT46_RS06065 (ETT46_06060) | - | 1162447..1164447 (-) | 2001 | WP_002994363.1 | potassium transporter Kup | - |
| ETT46_RS06070 (ETT46_06065) | - | 1164574..1166193 (-) | 1620 | WP_136265175.1 | DEAD/DEAH box helicase | - |
| ETT46_RS06075 (ETT46_06070) | - | 1166500..1168044 (-) | 1545 | WP_002989155.1 | peptide chain release factor 3 | - |
| ETT46_RS06085 (ETT46_06080) | - | 1168292..1168987 (-) | 696 | WP_002983946.1 | TIGR02206 family membrane protein | - |
| ETT46_RS06090 (ETT46_06085) | murF | 1169067..1170458 (-) | 1392 | WP_010922441.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| ETT46_RS06095 (ETT46_06090) | - | 1170649..1171695 (-) | 1047 | WP_136265177.1 | D-alanine--D-alanine ligase | - |
| ETT46_RS06100 (ETT46_06095) | recR | 1171796..1172392 (-) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| ETT46_RS09750 (ETT46_06100) | - | 1172439..1172630 (-) | 192 | WP_002983936.1 | hypothetical protein | - |
| ETT46_RS06110 (ETT46_06105) | - | 1173191..1173970 (-) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69371.22 Da Isoelectric Point: 4.7093
>NTDB_id=342413 ETT46_RS05985 WP_136265167.1 1147223..1149028(-) (pepF) [Streptococcus pyogenes strain emm100]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKSIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKSIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=342413 ETT46_RS05985 WP_136265167.1 1147223..1149028(-) (pepF) [Streptococcus pyogenes strain emm100]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAAGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAAGATTACGCAGATCGTGTGCATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCAG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAAGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAAGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAAGATTACGCAGATCGTGTGCATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCAG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAAGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
71.048 |
100 |
0.71 |