Detailed information NTG0342360

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ETT47_RS05970
• Genome accession: NZ_CP035452
• Coordinates: 1196054..1197091 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain emm123
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1191054..1202091

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT47_RS05945 (ETT47_05935)	-	1191058..1191585 (-)	528	WP_014635585.1	Dps family protein	-
ETT47_RS05950 (ETT47_05940)	-	1191813..1192439 (+)	627	WP_002989076.1	A24 family peptidase	-
ETT47_RS05955 (ETT47_05945)	rlmN	1192521..1193600 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ETT47_RS05960 (ETT47_05950)	-	1193604..1194224 (-)	621	WP_032464468.1	YutD family protein	-
ETT47_RS05965 (ETT47_05955)	-	1194672..1195649 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
ETT47_RS05970 (ETT47_05960)	sepM	1196054..1197091 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ETT47_RS05975 (ETT47_05965)	coaD	1197078..1197569 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ETT47_RS05980 (ETT47_05970)	rsmD	1197559..1198098 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ETT47_RS05985 (ETT47_05975)	asnA	1198221..1199213 (-)	993	WP_136099225.1	aspartate--ammonia ligase	-
ETT47_RS05990 (ETT47_05980)	arcC	1199526..1200476 (-)	951	WP_010922501.1	carbamate kinase	-
ETT47_RS05995 (ETT47_05985)	-	1200496..1201827 (-)	1332	WP_136099226.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=342360 ETT47_RS05970 WP_010922499.1 1196054..1197091(-) (sepM) [Streptococcus pyogenes strain emm123]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=342360 ETT47_RS05970 WP_010922499.1 1196054..1197091(-) (sepM) [Streptococcus pyogenes strain emm123]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693