Detailed information NTG0342252

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ETT49_RS05685
• Genome accession: NZ_CP035450
• Coordinates: 1125034..1126071 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain emm93.4
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1120034..1131071

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT49_RS05660 (ETT49_05655)	-	1120038..1120565 (-)	528	WP_047236116.1	Dps family protein	-
ETT49_RS05665 (ETT49_05660)	-	1120793..1121419 (+)	627	WP_002983834.1	A24 family peptidase	-
ETT49_RS05670 (ETT49_05665)	rlmN	1121501..1122580 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ETT49_RS05675 (ETT49_05670)	-	1122584..1123204 (-)	621	WP_002992791.1	YutD family protein	-
ETT49_RS05680 (ETT49_05675)	-	1123652..1124629 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
ETT49_RS05685 (ETT49_05680)	sepM	1125034..1126071 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ETT49_RS05690 (ETT49_05685)	coaD	1126058..1126549 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ETT49_RS05695 (ETT49_05690)	rsmD	1126539..1127078 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ETT49_RS05700 (ETT49_05695)	asnA	1127201..1128193 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
ETT49_RS05705 (ETT49_05700)	arcC	1128506..1129456 (-)	951	WP_010922501.1	carbamate kinase	-
ETT49_RS05710 (ETT49_05705)	-	1129476..1130807 (-)	1332	WP_136269419.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=342252 ETT49_RS05685 WP_010922499.1 1125034..1126071(-) (sepM) [Streptococcus pyogenes strain emm93.4]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=342252 ETT49_RS05685 WP_010922499.1 1125034..1126071(-) (sepM) [Streptococcus pyogenes strain emm93.4]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCAAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693