Detailed information NTG0342251

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: ETT49_RS05565
• Genome accession: NZ_CP035450
• Coordinates: 1099341..1101623 (+)
• Length: 760 a.a.
• NCBI ID: WP_136269413.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm93.4
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 1094341..1106623

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT49_RS05545 (ETT49_05540)	-	1095708..1097117 (-)	1410	WP_111713722.1	deoxyribodipyrimidine photo-lyase	-
ETT49_RS05550 (ETT49_05545)	-	1097266..1098000 (-)	735	WP_009880900.1	amino acid ABC transporter ATP-binding protein	-
ETT49_RS05555 (ETT49_05550)	-	1098000..1098686 (-)	687	WP_011054708.1	amino acid ABC transporter permease	-
ETT49_RS05560 (ETT49_05555)	-	1098813..1099043 (-)	231	WP_002983885.1	YkuJ family protein	-
ETT49_RS05565 (ETT49_05560)	clpE	1099341..1101623 (+)	2283	WP_136269413.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
ETT49_RS05570 (ETT49_05565)	-	1101751..1102206 (+)	456	WP_002989103.1	NUDIX hydrolase	-
ETT49_RS05575 (ETT49_05570)	-	1102257..1102559 (+)	303	WP_002983878.1	DUF1827 family protein	-
ETT49_RS05580 (ETT49_05575)	ileS	1102824..1105625 (-)	2802	WP_014635582.1	isoleucine--tRNA ligase	-

Sequence

Protein

• Length: 760 a.a.
• Molecular weight: 84705.84 Da
• Isoelectric Point: 5.0552

>NTDB_id=342251 ETT49_RS05565 WP_136269413.1 1099341..1101623(+) (clpE) [Streptococcus pyogenes strain emm93.4]
MLCQNCNLNESTIHLYTSVNGKQRQVDLCQNCYQIMKSDPANSILNGLTPGYRAQNRSTSPFFDDFFGDLNNFRAFGNLP
NTPPTQAGQNGNGGGRYGGNYNGQRPAQPQTPNQQAKGLLEEFGINVTDIARNGNIDPVIGRDEEITRVIEILNRRTKNN
PVLIGEPGVGKTAVVEGLAQKITDGTVPQKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRKDVILFIDEIHE
IVGAGSAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHH
VKYSPAAIEAAAHLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDKRLIEAENLKAQATRDEDYERAAYFRDQ
ITKYKEMQAQKVDEQDIPIITEKTIEAIVEQKTNIPVGDLKEKEQSQLVNLANDLKAHVIGQDDAVDKIAKAIRRNRVGL
GTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSTNNMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEQVRRNPY
SLILLDEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKSEASVGFGAAREGRTSSVLGELSNFFS
PEFMNRFDGIIEFKALSKEHLLHIVDLMLEDVNERLGYNGIHLDVTQKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAIT
DYYLEHPTEKQLRALMTNSENITIKAVKEGDSFLNEESLD

Nucleotide

• Length: 2283 bp

>NTDB_id=342251 ETT49_RS05565 WP_136269413.1 1099341..1101623(+) (clpE) [Streptococcus pyogenes strain emm93.4]
ATGCTGTGTCAAAATTGTAATTTAAACGAATCTACTATTCATCTTTATACAAGTGTTAATGGAAAACAAAGACAGGTTGA
TCTCTGTCAAAATTGTTATCAAATCATGAAATCCGATCCTGCCAATTCTATTTTAAATGGCCTAACCCCAGGATATAGAG
CACAAAATAGATCCACAAGTCCTTTCTTTGATGACTTTTTTGGTGATTTGAATAATTTTAGAGCTTTTGGTAATCTTCCA
AATACCCCACCTACTCAGGCAGGGCAAAATGGAAATGGCGGAGGACGCTATGGTGGTAACTACAACGGACAACGACCTGC
TCAGCCACAAACACCAAATCAGCAAGCAAAGGGCTTATTAGAAGAGTTTGGGATTAATGTCACAGATATTGCAAGAAATG
GTAATATTGATCCTGTTATTGGTCGTGACGAAGAGATTACACGCGTTATCGAGATCCTCAACCGCCGTACTAAAAATAAT
CCTGTGCTAATTGGTGAGCCTGGAGTTGGTAAAACTGCTGTTGTAGAAGGTTTGGCTCAAAAAATTACTGATGGTACTGT
TCCTCAAAAACTCCAAGGCAAGCAAGTGATTCGTCTTGATGTGGTTAGCCTCGTTCAGGGAACAGGTATCCGTGGTCAGT
TTGAAGAGCGCATGCAAAAATTAATGGAAGAAATCCGCAATCGCAAGGATGTGATTCTCTTTATTGATGAAATTCATGAG
ATTGTCGGTGCTGGTTCTGCAGGAGACGGCAATATGGATGCTGGTAATATTTTAAAACCAGCCTTGGCCCGTGGTGAGTT
GCAACTCGTTGGTGCTACTACATTAAATGAATACCGTATTATTGAAAAAGACGCTGCCTTAGAACGACGTATGCAACCCG
TTAAAGTTGATGAACCTTCTGTTGAGGAAACCATCACGATTTTAAAAGGTATCCAACCGAAATACGAAGACTATCATCAT
GTCAAATATAGCCCAGCCGCTATTGAAGCTGCCGCTCATTTATCTAACCGCTATATTCAAGACCGTTTTCTTCCTGATAA
GGCTATTGATCTTCTGGACGAAGCTGGTTCCAAAATGAATCTAACCCTCAACTTTGTTGATCCTAAAGAAATTGACAAAC
GTCTTATTGAAGCTGAGAATCTCAAGGCGCAAGCTACTCGAGACGAAGACTATGAACGCGCAGCTTATTTCCGCGATCAA
ATTACAAAATACAAAGAAATGCAGGCTCAAAAAGTCGATGAGCAAGATATTCCCATCATTACTGAAAAAACCATTGAAGC
TATTGTAGAGCAAAAAACTAATATTCCAGTTGGGGACTTAAAAGAAAAGGAACAGTCTCAACTCGTAAACTTAGCCAATG
ATCTGAAAGCACACGTGATCGGGCAAGACGATGCTGTTGATAAAATCGCTAAGGCTATTCGTCGTAACCGTGTGGGATTA
GGAACTCCAAATCGCCCTATTGGTTCTTTCTTATTCGTTGGACCGACTGGGGTTGGTAAAACTGAATTGTCTAAACAACT
AGCCATTGAACTCTTTGGTTCGACAAACAATATGATTCGCTTTGACATGTCCGAATACATGGAAAAACACGCTGTCGCCA
AATTAGTCGGGGCTCCTCCAGGTTATGTCGGCTATGAAGAAGCTGGACAGCTAACCGAACAAGTTCGTCGCAATCCATAT
TCACTTATTCTCTTAGATGAGGTGGAAAAAGCCCATCCTGACGTCATGCACATGTTCTTACAAGTTCTTGATGATGGCCG
TTTAACAGATGGTCAAGGACGAACAGTCAGCTTCAAGGACACCATTATTATCATGACCTCTAATGCCGGAACAGGTAAAA
GCGAAGCTTCTGTCGGATTTGGTGCTGCTAGAGAAGGACGGACAAGTTCTGTCCTTGGTGAATTAAGCAACTTCTTCAGC
CCAGAGTTTATGAATCGTTTCGATGGTATTATTGAATTCAAAGCTTTATCTAAAGAGCATTTGCTGCATATCGTTGATTT
AATGCTGGAAGATGTTAATGAGCGCTTAGGCTATAATGGGATTCATCTTGATGTGACACAAAAGGTCAAAGAAAAATTAG
TAGATTTAGGCTATGATCCTAAAATGGGCGCTCGACCGCTCCGTCGTACTATCCAAGATTATATCGAAGATGCCATTACA
GACTATTATTTAGAACACCCAACTGAAAAACAGTTACGTGCACTGATGACAAACAGTGAAAACATCACGATTAAAGCTGT
TAAAGAGGGAGATTCTTTTCTTAACGAAGAGTCTCTCGATTAA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (300-397)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (656-729)

• AAA domain (Cdc48 subfamily) (AAA_2) (485-648)

• ATPase family associated with various cellular activities (AAA) (AAA) (162-281)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	84.759	98.421	0.834
clpE	Streptococcus pneumoniae Rx1	82.823	98.816	0.818
clpE	Streptococcus pneumoniae D39	82.823	98.816	0.818
clpE	Streptococcus pneumoniae R6	82.823	98.816	0.818
clpE	Streptococcus pneumoniae TIGR4	82.69	98.816	0.817
clpC	Lactococcus lactis subsp. cremoris KW2	75.164	100	0.753
clpC	Bacillus subtilis subsp. subtilis str. 168	51.442	86.711	0.446
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	46	85.526	0.393
clpC	Streptococcus pneumoniae Rx1	47.84	82.237	0.393
clpC	Streptococcus pneumoniae D39	47.84	82.237	0.393
clpC	Streptococcus pneumoniae TIGR4	47.84	82.237	0.393
clpC	Streptococcus mutans UA159	47.573	81.316	0.387
clpC	Streptococcus thermophilus LMD-9	47.115	82.105	0.387
clpC	Streptococcus thermophilus LMG 18311	46.795	82.105	0.384