Detailed information NTG0342142

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ETT51_RS06465
• Genome accession: NZ_CP035448
• Coordinates: 1257543..1258580 (-)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain emm70
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1252543..1263580

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT51_RS06445 (ETT51_06525)	-	1253284..1253910 (+)	627	WP_002983834.1	prepilin peptidase	-
ETT51_RS06450 (ETT51_06530)	rlmN	1253992..1255071 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ETT51_RS06455 (ETT51_06535)	-	1255075..1255695 (-)	621	WP_002992791.1	YutD family protein	-
ETT51_RS06460 (ETT51_06540)	-	1256143..1257120 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
ETT51_RS06465 (ETT51_06545)	sepM	1257543..1258580 (-)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
ETT51_RS06470 (ETT51_06550)	coaD	1258567..1259058 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ETT51_RS06475 (ETT51_06555)	rsmD	1259048..1259587 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ETT51_RS06480 (ETT51_06560)	asnA	1259710..1260702 (-)	993	WP_002994813.1	aspartate--ammonia ligase	-
ETT51_RS06485 (ETT51_06565)	arcC	1261015..1261965 (-)	951	WP_002994815.1	carbamate kinase	-
ETT51_RS06490 (ETT51_06570)	-	1261985..1263316 (-)	1332	WP_011054719.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=342142 ETT51_RS06465 WP_002983824.1 1257543..1258580(-) (sepM) [Streptococcus pyogenes strain emm70]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=342142 ETT51_RS06465 WP_002983824.1 1257543..1258580(-) (sepM) [Streptococcus pyogenes strain emm70]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAACGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69