Detailed information NTG0342082

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ETT52_RS05965
• Genome accession: NZ_CP035447
• Coordinates: 1179237..1180274 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain emm97.1
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1174237..1185274

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT52_RS05945 (ETT52_05935)	-	1174987..1175613 (+)	627	WP_002989076.1	A24 family peptidase	-
ETT52_RS05950 (ETT52_05940)	rlmN	1175695..1176774 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ETT52_RS05955 (ETT52_05945)	-	1176778..1177398 (-)	621	WP_002992791.1	YutD family protein	-
ETT52_RS05960 (ETT52_05950)	-	1177846..1178823 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
ETT52_RS05965 (ETT52_05955)	sepM	1179237..1180274 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ETT52_RS05970 (ETT52_05960)	coaD	1180261..1180752 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ETT52_RS05975 (ETT52_05965)	rsmD	1180742..1181281 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ETT52_RS05980 (ETT52_05970)	asnA	1181404..1182396 (-)	993	WP_109828593.1	aspartate--ammonia ligase	-
ETT52_RS05985 (ETT52_05975)	arcC	1182709..1183659 (-)	951	WP_009880962.1	carbamate kinase	-
ETT52_RS05990 (ETT52_05980)	-	1183679..1185010 (-)	1332	WP_109828595.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=342082 ETT52_RS05965 WP_010922499.1 1179237..1180274(-) (sepM) [Streptococcus pyogenes strain emm97.1]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=342082 ETT52_RS05965 WP_010922499.1 1179237..1180274(-) (sepM) [Streptococcus pyogenes strain emm97.1]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693