Detailed information    

insolico Bioinformatically predicted

Overview

Name   pepF   Type   Regulator
Locus tag   ETT54_RS05630 Genome accession   NZ_CP035445
Coordinates   1100480..1102285 (-) Length   601 a.a.
NCBI ID   WP_136098245.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm92     
Function   degradation of XIP; competence shut-off (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1080172..1110109 1100480..1102285 within 0


Gene organization within MGE regions


Location: 1080172..1110109
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT54_RS05545 (ETT54_05540) - 1080229..1081503 (-) 1275 WP_011017930.1 polysaccharide deacetylase family protein -
  ETT54_RS05550 (ETT54_05545) - 1081598..1083025 (-) 1428 WP_136298574.1 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase -
  ETT54_RS05555 (ETT54_05550) ptsP 1083210..1084943 (-) 1734 WP_002984033.1 phosphoenolpyruvate--protein phosphotransferase -
  ETT54_RS05560 (ETT54_05555) - 1084948..1085211 (-) 264 WP_002984031.1 phosphocarrier protein HPr -
  ETT54_RS05565 (ETT54_05560) - 1085604..1085822 (+) 219 WP_002989242.1 redoxin NrdH -
  ETT54_RS05570 (ETT54_05565) nrdE 1085842..1088001 (+) 2160 WP_136098248.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
  ETT54_RS05575 (ETT54_05570) nrdF 1088334..1089293 (+) 960 WP_002987365.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
  ETT54_RS05580 (ETT54_05575) - 1089355..1090581 (+) 1227 WP_391592263.1 chloride channel protein -
  ETT54_RS05590 (ETT54_05585) - 1090719..1091869 (+) 1151 Protein_1046 IS3 family transposase -
  ETT54_RS05595 (ETT54_05590) - 1091967..1092662 (-) 696 WP_136046638.1 CPBP family intramembrane glutamic endopeptidase -
  ETT54_RS05600 (ETT54_05595) - 1092681..1093442 (-) 762 WP_053308456.1 DUF3169 family protein -
  ETT54_RS05605 (ETT54_05600) - 1093439..1093654 (-) 216 WP_002989220.1 helix-turn-helix transcriptional regulator -
  ETT54_RS05610 (ETT54_05605) alaS 1094012..1096630 (-) 2619 WP_136098247.1 alanine--tRNA ligase -
  ETT54_RS05615 (ETT54_05610) prsA 1097017..1098072 (-) 1056 WP_002984003.1 peptidylprolyl isomerase PrsA -
  ETT54_RS05620 (ETT54_05615) - 1098135..1098842 (-) 708 WP_002989211.1 O-methyltransferase -
  ETT54_RS05625 (ETT54_05620) - 1098908..1100104 (-) 1197 WP_136098246.1 OFA family MFS transporter -
  ETT54_RS05630 (ETT54_05625) pepF 1100480..1102285 (-) 1806 WP_136098245.1 oligoendopeptidase F Regulator
  ETT54_RS05635 (ETT54_05630) - 1102298..1103260 (-) 963 WP_010922426.1 competence protein CoiA -
  ETT54_RS05640 (ETT54_05635) - 1103555..1104271 (-) 717 WP_002995774.1 pseudouridine synthase -
  ETT54_RS05645 (ETT54_05640) nagB 1104390..1105094 (-) 705 WP_010922428.1 glucosamine-6-phosphate deaminase -
  ETT54_RS05650 (ETT54_05645) queA 1105296..1106324 (+) 1029 WP_010922429.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
  ETT54_RS05655 (ETT54_05650) - 1106331..1107551 (+) 1221 WP_010922430.1 DUF3114 domain-containing protein -
  ETT54_RS05660 (ETT54_05655) - 1107665..1108255 (-) 591 WP_010922431.1 serine hydrolase -
  ETT54_RS05665 (ETT54_05660) - 1108252..1108500 (-) 249 WP_010922432.1 serine hydrolase -
  ETT54_RS05670 (ETT54_05665) - 1108485..1108712 (-) 228 WP_010922433.1 hypothetical protein -
  ETT54_RS05675 (ETT54_05670) sodA 1108879..1109484 (-) 606 WP_010922434.1 superoxide dismutase SodA -

Sequence

Protein


Download         Length: 601 a.a.        Molecular weight: 69421.41 Da        Isoelectric Point: 4.7783

>NTDB_id=341975 ETT54_RS05630 WP_136098245.1 1100480..1102285(-) (pepF) [Streptococcus pyogenes strain emm92]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNRHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFILLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMEKGDYLEAAFKVFDERLTELEVLVSKGIHKS

Nucleotide


Download         Length: 1806 bp        

>NTDB_id=341975 ETT54_RS05630 WP_136098245.1 1100480..1102285(-) (pepF) [Streptococcus pyogenes strain emm92]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTTCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAATAGACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAAGATTACGCAGATCGTGTGCATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTTATTCTGTTGAATT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAATATTATGACAGAAGC
TCTCTTAAATGAGGTTCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCAG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGAAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA

Domains

Predicted by InterproScan.

Peptidase family M3 (Peptidase_M3)

(202-581)

Oligopeptidase F (Peptidase_M3_N)

(112-181)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pepF Streptococcus salivarius strain HSISS4

70.383

100

0.704

Multiple sequence alignment