Detailed information NTG0341858

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ETT56_RS03070
• Genome accession: NZ_CP035443
• Coordinates: 595104..596141 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain emm58
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 590104..601141

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT56_RS03045 (ETT56_03045)	-	590368..591699 (+)	1332	WP_023610927.1	dipeptidase	-
ETT56_RS03050 (ETT56_03050)	arcC	591719..592669 (+)	951	WP_063632991.1	carbamate kinase	-
ETT56_RS03055 (ETT56_03055)	asnA	592982..593974 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
ETT56_RS03060 (ETT56_03060)	rsmD	594097..594636 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ETT56_RS03065 (ETT56_03065)	coaD	594626..595117 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ETT56_RS03070 (ETT56_03070)	sepM	595104..596141 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ETT56_RS03075 (ETT56_03075)	-	596546..597523 (+)	978	WP_023610939.1	LacI family DNA-binding transcriptional regulator	-
ETT56_RS03080 (ETT56_03080)	-	597971..598591 (+)	621	WP_023610891.1	YutD family protein	-
ETT56_RS03085 (ETT56_03085)	rlmN	598595..599674 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ETT56_RS03090 (ETT56_03090)	-	599756..600382 (-)	627	WP_002989076.1	A24 family peptidase	-
ETT56_RS03095 (ETT56_03095)	-	600610..601137 (+)	528	WP_002983837.1	Dps family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=341858 ETT56_RS03070 WP_010922499.1 595104..596141(+) (sepM) [Streptococcus pyogenes strain emm58]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=341858 ETT56_RS03070 WP_010922499.1 595104..596141(+) (sepM) [Streptococcus pyogenes strain emm58]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693