Detailed information NTG0341817

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ETT57_RS06455
• Genome accession: NZ_CP035442
• Coordinates: 1238605..1239642 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain emm25
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1233605..1244642

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT57_RS06435 (ETT57_06425)	-	1234355..1234981 (+)	627	WP_002983834.1	A24 family peptidase	-
ETT57_RS06440 (ETT57_06430)	rlmN	1235063..1236142 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ETT57_RS06445 (ETT57_06435)	-	1236146..1236766 (-)	621	WP_168389412.1	YutD family protein	-
ETT57_RS06450 (ETT57_06440)	-	1237214..1238191 (-)	978	WP_136048663.1	LacI family DNA-binding transcriptional regulator	-
ETT57_RS06455 (ETT57_06445)	sepM	1238605..1239642 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ETT57_RS06460 (ETT57_06450)	coaD	1239629..1240120 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ETT57_RS06465 (ETT57_06455)	rsmD	1240110..1240649 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ETT57_RS06470 (ETT57_06460)	asnA	1240772..1241764 (-)	993	WP_032460542.1	aspartate--ammonia ligase	-
ETT57_RS06475 (ETT57_06465)	arcC	1242077..1243027 (-)	951	WP_009880962.1	carbamate kinase	-
ETT57_RS06480 (ETT57_06470)	-	1243047..1244378 (-)	1332	WP_136048662.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=341817 ETT57_RS06455 WP_010922499.1 1238605..1239642(-) (sepM) [Streptococcus pyogenes strain emm25]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=341817 ETT57_RS06455 WP_010922499.1 1238605..1239642(-) (sepM) [Streptococcus pyogenes strain emm25]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693