Detailed information NTG0341757

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ETT58_RS06530
• Genome accession: NZ_CP035441
• Coordinates: 1243748..1244785 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain emm1
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1238748..1249785

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT58_RS06510 (ETT58_06505)	-	1239499..1240125 (+)	627	WP_010922497.1	A24 family peptidase	-
ETT58_RS06515 (ETT58_06510)	rlmN	1240207..1241286 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ETT58_RS06520 (ETT58_06515)	-	1241290..1241910 (-)	621	WP_011285637.1	YutD family protein	-
ETT58_RS06525 (ETT58_06520)	-	1242358..1243334 (-)	977	Protein_1212	LacI family DNA-binding transcriptional regulator	-
ETT58_RS06530 (ETT58_06525)	sepM	1243748..1244785 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ETT58_RS06535 (ETT58_06530)	coaD	1244772..1245263 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ETT58_RS06540 (ETT58_06535)	rsmD	1245253..1245792 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ETT58_RS06545 (ETT58_06540)	asnA	1245915..1246907 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
ETT58_RS06550 (ETT58_06545)	arcC	1247220..1248170 (-)	951	WP_010922501.1	carbamate kinase	-
ETT58_RS06555 (ETT58_06550)	-	1248190..1249521 (-)	1332	WP_011285641.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=341757 ETT58_RS06530 WP_010922499.1 1243748..1244785(-) (sepM) [Streptococcus pyogenes strain emm1]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=341757 ETT58_RS06530 WP_010922499.1 1243748..1244785(-) (sepM) [Streptococcus pyogenes strain emm1]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693