Detailed information NTG0341654

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ETT60_RS06300
• Genome accession: NZ_CP035439
• Coordinates: 1219060..1220097 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain emm77
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1214060..1225097

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT60_RS06280 (ETT60_06270)	-	1214810..1215436 (+)	627	WP_038434165.1	A24 family peptidase	-
ETT60_RS06285 (ETT60_06275)	rlmN	1215518..1216597 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ETT60_RS06290 (ETT60_06280)	-	1216601..1217221 (-)	621	WP_038434166.1	YutD family protein	-
ETT60_RS06295 (ETT60_06285)	-	1217669..1218646 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
ETT60_RS06300 (ETT60_06290)	sepM	1219060..1220097 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ETT60_RS06305 (ETT60_06295)	coaD	1220084..1220575 (-)	492	WP_014407698.1	pantetheine-phosphate adenylyltransferase	-
ETT60_RS06310 (ETT60_06300)	rsmD	1220565..1221104 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ETT60_RS06315 (ETT60_06305)	asnA	1221227..1222219 (-)	993	WP_129284342.1	aspartate--ammonia ligase	-
ETT60_RS06320 (ETT60_06310)	arcC	1222532..1223482 (-)	951	WP_009880962.1	carbamate kinase	-
ETT60_RS06325 (ETT60_06315)	-	1223502..1224833 (-)	1332	WP_129284341.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=341654 ETT60_RS06300 WP_010922499.1 1219060..1220097(-) (sepM) [Streptococcus pyogenes strain emm77]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=341654 ETT60_RS06300 WP_010922499.1 1219060..1220097(-) (sepM) [Streptococcus pyogenes strain emm77]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693