Detailed information NTG0341653

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: ETT60_RS06180
• Genome accession: NZ_CP035439
• Coordinates: 1193357..1195639 (+)
• Length: 760 a.a.
• NCBI ID: WP_136114761.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm77
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 1188357..1200639

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT60_RS06160 (ETT60_06150)	-	1189724..1191133 (-)	1410	WP_129284349.1	deoxyribodipyrimidine photo-lyase	-
ETT60_RS06165 (ETT60_06155)	-	1191282..1192016 (-)	735	WP_002989107.1	amino acid ABC transporter ATP-binding protein	-
ETT60_RS06170 (ETT60_06160)	-	1192016..1192702 (-)	687	WP_002983887.1	amino acid ABC transporter permease	-
ETT60_RS06175 (ETT60_06165)	-	1192829..1193059 (-)	231	WP_002983885.1	YkuJ family protein	-
ETT60_RS06180 (ETT60_06170)	clpE	1193357..1195639 (+)	2283	WP_136114761.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
ETT60_RS06185 (ETT60_06175)	-	1195767..1196222 (+)	456	WP_011284955.1	NUDIX hydrolase	-
ETT60_RS06190 (ETT60_06180)	-	1196273..1196575 (+)	303	WP_002983878.1	DUF1827 family protein	-
ETT60_RS06195 (ETT60_06185)	ileS	1196840..1199641 (-)	2802	WP_129284347.1	isoleucine--tRNA ligase	-

Sequence

Protein

• Length: 760 a.a.
• Molecular weight: 84743.88 Da
• Isoelectric Point: 5.0109

>NTDB_id=341653 ETT60_RS06180 WP_136114761.1 1193357..1195639(+) (clpE) [Streptococcus pyogenes strain emm77]
MLCQNCNLNESTIHLYTSVNGKQRQVDLCQNCYQIMKSDPANSILNGLTPGYRAQDRSTSPFFDDFFGDLNNFRAFGNLP
NTPPTQAGQNGNGGGRYGGNYNGQRPAQPQTPNQQAKGLLEEFGINVTDIARNGNIDPVIGRDEEITRIIEILNRRTKNN
PVLIGEPGVGKTAVVEGLAQKIIDGTVPQKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRKDVILFIDEIHE
IVGAGSAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHH
VKYSPAAIEAAAHLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDKHLIEAENLKAQATRDEDYERAAYFRDQ
ITKYKEMQAQKVDEQDIPIITEKTIEAIVEQKTNIPVGDLKEKEQSQLVNLANDLKAHVIGQDDAVDKIAKAIRRNRVGL
GTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSTNNMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEQVRRNPY
SLILLDEVEKAHPDVMHMFLQVLDDSRLTDGQGRTVSFKDTIIIMTSNAGTGKSEASVGFGAAREGRTSSVLGELSNFFS
PEFMNRFDGIIEFKALSKEHLLHIVDLMLEDVNERLGYNGIHLDVTQKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAIT
DYYLEHPTEKQLRALMTNSENITIKAVKEGDSFLNEESLD

Nucleotide

• Length: 2283 bp

>NTDB_id=341653 ETT60_RS06180 WP_136114761.1 1193357..1195639(+) (clpE) [Streptococcus pyogenes strain emm77]
ATGCTGTGTCAAAATTGTAATTTAAACGAATCTACTATTCATCTTTATACAAGTGTTAATGGAAAACAAAGACAGGTTGA
TCTCTGTCAAAATTGTTATCAAATCATGAAATCCGATCCTGCCAATTCTATTTTAAATGGCCTAACCCCAGGATATAGAG
CACAAGATAGATCCACAAGTCCTTTCTTTGATGACTTTTTTGGTGATTTGAATAATTTTAGAGCTTTTGGTAATCTTCCA
AATACCCCACCTACTCAGGCAGGGCAAAATGGAAATGGCGGAGGACGCTATGGTGGTAACTACAACGGACAACGACCTGC
TCAGCCACAAACACCAAATCAGCAAGCAAAGGGCTTGTTAGAAGAGTTTGGGATTAATGTCACAGATATTGCAAGAAATG
GTAATATTGATCCTGTTATTGGTCGTGACGAAGAGATTACACGCATTATCGAGATCCTCAACCGCCGTACTAAAAATAAT
CCTGTGCTAATTGGTGAGCCTGGAGTTGGTAAAACTGCTGTTGTAGAAGGTTTGGCTCAAAAAATTATTGATGGTACTGT
TCCTCAAAAACTCCAAGGCAAGCAAGTGATTCGTCTTGATGTGGTTAGCCTCGTTCAGGGAACAGGTATCCGTGGTCAGT
TTGAAGAGCGCATGCAAAAATTAATGGAAGAAATTCGCAATCGCAAGGATGTGATTCTCTTTATTGATGAAATTCATGAG
ATTGTCGGTGCTGGTTCTGCAGGAGACGGCAATATGGATGCTGGTAATATTTTAAAACCAGCCTTGGCCCGCGGTGAATT
GCAGTTGGTCGGCGCTACCACCTTAAATGAATATCGTATTATTGAAAAAGACGCTGCCTTAGAACGACGTATGCAACCCG
TTAAAGTTGATGAACCTTCTGTTGAGGAAACCATCACGATTTTAAAAGGTATCCAACCGAAATACGAAGACTATCATCAT
GTCAAATATAGCCCAGCCGCTATTGAAGCTGCCGCTCATTTATCTAACCGCTATATTCAAGACCGTTTTCTTCCTGATAA
GGCTATTGACCTTCTGGACGAAGCTGGTTCCAAAATGAATCTAACCCTCAACTTTGTTGATCCTAAAGAAATTGACAAAC
ATCTTATTGAAGCTGAGAATCTCAAGGCGCAAGCTACTCGAGACGAAGACTATGAACGCGCAGCTTATTTCCGCGATCAA
ATTACAAAATACAAAGAAATGCAGGCTCAAAAAGTCGATGAGCAAGATATTCCCATCATTACTGAAAAAACCATTGAAGC
TATTGTAGAGCAAAAAACTAATATTCCAGTTGGGGACTTAAAAGAAAAGGAACAGTCTCAACTCGTAAACTTAGCCAATG
ATCTGAAAGCACACGTGATCGGGCAAGACGATGCTGTTGATAAAATCGCTAAGGCTATTCGTCGTAACCGTGTGGGATTA
GGAACTCCAAATCGCCCTATTGGTTCTTTCTTATTCGTTGGACCGACTGGGGTTGGTAAAACTGAATTGTCTAAACAACT
AGCCATTGAACTCTTTGGTTCGACAAACAATATGATTCGCTTTGACATGTCCGAATACATGGAAAAACACGCTGTCGCCA
AATTAGTCGGGGCTCCTCCAGGTTATGTCGGCTATGAAGAAGCTGGACAGCTAACCGAACAAGTTCGTCGCAATCCTTAT
TCCCTTATTCTCTTAGATGAGGTGGAAAAAGCCCATCCTGACGTCATGCACATGTTCTTACAAGTTCTTGATGACAGTCG
CTTAACAGACGGCCAAGGGCGAACAGTCAGCTTCAAGGACACCATTATTATCATGACCTCTAATGCCGGAACAGGTAAAA
GCGAAGCTTCTGTCGGATTTGGTGCTGCTAGAGAAGGACGGACAAGTTCTGTCCTTGGTGAATTAAGCAACTTCTTCAGC
CCAGAGTTTATGAATCGTTTCGATGGTATTATTGAATTCAAAGCTTTATCTAAAGAGCATTTGCTGCATATCGTTGATTT
AATGCTGGAAGATGTTAATGAGCGCTTAGGCTATAATGGGATTCATCTTGATGTGACACAAAAGGTCAAAGAAAAATTAG
TAGATTTAGGCTATGATCCTAAAATGGGCGCTCGGCCGCTCCGTCGTACTATCCAAGATTATATCGAAGATGCCATTACA
GACTATTATTTAGAACACCCAACTGAAAAACAGTTACGTGCACTGATGACAAACAGTGAAAACATCACGATTAAAGCTGT
TAAAGAGGGAGATTCTTTTCTTAACGAAGAGTCTCTAGATTAA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (300-397)

• ATPase family associated with various cellular activities (AAA) (AAA) (162-281)

• AAA domain (Cdc48 subfamily) (AAA_2) (485-648)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (656-729)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	84.358	98.421	0.83
clpE	Streptococcus pneumoniae Rx1	82.29	98.816	0.813
clpE	Streptococcus pneumoniae D39	82.29	98.816	0.813
clpE	Streptococcus pneumoniae R6	82.29	98.816	0.813
clpE	Streptococcus pneumoniae TIGR4	82.157	98.816	0.812
clpC	Lactococcus lactis subsp. cremoris KW2	74.77	100	0.749
clpC	Bacillus subtilis subsp. subtilis str. 168	51.29	86.711	0.445
clpC	Streptococcus pneumoniae D39	47.68	82.237	0.392
clpC	Streptococcus pneumoniae Rx1	47.68	82.237	0.392
clpC	Streptococcus pneumoniae TIGR4	47.68	82.237	0.392
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	45.846	85.526	0.392
clpC	Streptococcus thermophilus LMD-9	46.955	82.105	0.386
clpC	Streptococcus mutans UA159	47.642	80.921	0.386
clpC	Streptococcus thermophilus LMG 18311	46.635	82.105	0.383