Detailed information NTG0341600

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ETT61_RS07010
• Genome accession: NZ_CP035438
• Coordinates: 1330980..1332017 (-)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain emm22.8
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1325980..1337017

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT61_RS06985 (ETT61_06975)	-	1325984..1326511 (-)	528	WP_002983837.1	Dps family protein	-
ETT61_RS06990 (ETT61_06980)	-	1326739..1327365 (+)	627	WP_136020137.1	A24 family peptidase	-
ETT61_RS06995 (ETT61_06985)	rlmN	1327447..1328526 (-)	1080	WP_136020138.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ETT61_RS07000 (ETT61_06990)	-	1328530..1329150 (-)	621	WP_168389620.1	YutD family protein	-
ETT61_RS07005 (ETT61_06995)	-	1329598..1330575 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
ETT61_RS07010 (ETT61_07000)	sepM	1330980..1332017 (-)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
ETT61_RS07015 (ETT61_07005)	coaD	1332004..1332495 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ETT61_RS07020 (ETT61_07010)	rsmD	1332485..1333024 (-)	540	WP_038434169.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ETT61_RS07025 (ETT61_07015)	asnA	1333147..1334139 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
ETT61_RS07030 (ETT61_07020)	arcC	1334452..1335402 (-)	951	WP_136020139.1	carbamate kinase	-
ETT61_RS07035 (ETT61_07025)	-	1335422..1336753 (-)	1332	WP_136020140.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=341600 ETT61_RS07010 WP_002983824.1 1330980..1332017(-) (sepM) [Streptococcus pyogenes strain emm22.8]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=341600 ETT61_RS07010 WP_002983824.1 1330980..1332017(-) (sepM) [Streptococcus pyogenes strain emm22.8]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGTCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCTTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAGCGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69