Detailed information NTG0341536

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ETT62_RS03035
• Genome accession: NZ_CP035437
• Coordinates: 586421..587458 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain emm78.3
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 581421..592458

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT62_RS03010 (ETT62_03010)	-	581685..583016 (+)	1332	WP_032460502.1	dipeptidase	-
ETT62_RS03015 (ETT62_03015)	arcC	583036..583986 (+)	951	WP_010922501.1	carbamate kinase	-
ETT62_RS03020 (ETT62_03020)	asnA	584299..585291 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
ETT62_RS03025 (ETT62_03025)	rsmD	585414..585953 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ETT62_RS03030 (ETT62_03030)	coaD	585943..586434 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ETT62_RS03035 (ETT62_03035)	sepM	586421..587458 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ETT62_RS03040 (ETT62_03040)	-	587863..588840 (+)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
ETT62_RS03045 (ETT62_03045)	-	589288..589908 (+)	621	WP_002992791.1	YutD family protein	-
ETT62_RS03050 (ETT62_03050)	rlmN	589912..590991 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ETT62_RS03055 (ETT62_03055)	-	591073..591699 (-)	627	WP_002989076.1	A24 family peptidase	-
ETT62_RS03060 (ETT62_03060)	-	591927..592454 (+)	528	WP_014635585.1	Dps family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=341536 ETT62_RS03035 WP_010922499.1 586421..587458(+) (sepM) [Streptococcus pyogenes strain emm78.3]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=341536 ETT62_RS03035 WP_010922499.1 586421..587458(+) (sepM) [Streptococcus pyogenes strain emm78.3]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693