Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | ETT63_RS03375 | Genome accession | NZ_CP035436 |
| Coordinates | 657488..659293 (+) | Length | 601 a.a. |
| NCBI ID | WP_002995768.1 | Uniprot ID | A0A660A6L4 |
| Organism | Streptococcus pyogenes strain emm89.14 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 632509..680899 | 657488..659293 | within | 0 |
Gene organization within MGE regions
Location: 632509..680899
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ETT63_RS03250 (ETT63_03250) | - | 632561..633340 (+) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
| ETT63_RS09455 (ETT63_03255) | - | 633900..634091 (+) | 192 | WP_012560809.1 | hypothetical protein | - |
| ETT63_RS03260 (ETT63_03260) | recR | 634138..634734 (+) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| ETT63_RS03265 (ETT63_03265) | - | 634835..635881 (+) | 1047 | WP_136267725.1 | D-alanine--D-alanine ligase | - |
| ETT63_RS03270 (ETT63_03270) | murF | 636080..637471 (+) | 1392 | WP_010922441.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| ETT63_RS03275 (ETT63_03275) | - | 637551..638246 (+) | 696 | WP_002983946.1 | TIGR02206 family membrane protein | - |
| ETT63_RS03285 (ETT63_03285) | - | 638484..640028 (+) | 1545 | WP_002989155.1 | peptide chain release factor 3 | - |
| ETT63_RS03290 (ETT63_03290) | - | 640335..641954 (+) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| ETT63_RS03295 (ETT63_03295) | - | 642082..644082 (+) | 2001 | WP_136273428.1 | potassium transporter Kup | - |
| ETT63_RS03300 (ETT63_03300) | - | 644106..644384 (-) | 279 | WP_002989164.1 | GIY-YIG nuclease family protein | - |
| ETT63_RS03305 (ETT63_03305) | - | 644374..645150 (-) | 777 | WP_010922438.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| ETT63_RS03310 (ETT63_03310) | - | 645268..646008 (+) | 741 | WP_002989170.1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase | - |
| ETT63_RS03315 (ETT63_03315) | - | 646208..646870 (+) | 663 | WP_002983967.1 | ComEA family DNA-binding protein | - |
| ETT63_RS03320 (ETT63_03320) | - | 646851..649094 (+) | 2244 | WP_002989173.1 | DNA internalization-related competence protein ComEC/Rec2 | - |
| ETT63_RS03325 (ETT63_03325) | holA | 649165..650205 (+) | 1041 | WP_011888795.1 | DNA polymerase III subunit delta | - |
| ETT63_RS03330 (ETT63_03330) | sodA | 650302..650907 (+) | 606 | WP_023612500.1 | superoxide dismutase SodA | - |
| ETT63_RS03335 (ETT63_03335) | - | 651074..651301 (+) | 228 | WP_011054657.1 | hypothetical protein | - |
| ETT63_RS03345 (ETT63_03345) | - | 651286..652108 (+) | 823 | Protein_583 | serine hydrolase | - |
| ETT63_RS03350 (ETT63_03350) | - | 652222..653442 (-) | 1221 | WP_030126414.1 | DUF3114 domain-containing protein | - |
| ETT63_RS03355 (ETT63_03355) | queA | 653449..654477 (-) | 1029 | WP_002983989.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| ETT63_RS03360 (ETT63_03360) | nagB | 654679..655428 (+) | 750 | WP_038434150.1 | glucosamine-6-phosphate deaminase | - |
| ETT63_RS03365 (ETT63_03365) | - | 655502..656218 (+) | 717 | WP_136267729.1 | pseudouridine synthase | - |
| ETT63_RS03370 (ETT63_03370) | - | 656513..657475 (+) | 963 | WP_136267731.1 | competence protein CoiA | - |
| ETT63_RS03375 (ETT63_03375) | pepF | 657488..659293 (+) | 1806 | WP_002995768.1 | oligoendopeptidase F | Regulator |
| ETT63_RS03380 (ETT63_03380) | - | 659668..660864 (+) | 1197 | WP_063631969.1 | OFA family MFS transporter | - |
| ETT63_RS03385 (ETT63_03385) | - | 660930..661637 (+) | 708 | WP_063631966.1 | O-methyltransferase | - |
| ETT63_RS03390 (ETT63_03390) | prsA | 661700..662755 (+) | 1056 | WP_002984003.1 | peptidylprolyl isomerase PrsA | - |
| ETT63_RS03395 (ETT63_03395) | alaS | 663142..665760 (+) | 2619 | WP_136267733.1 | alanine--tRNA ligase | - |
| ETT63_RS03400 (ETT63_03400) | - | 666120..666329 (+) | 210 | WP_136267735.1 | helix-turn-helix transcriptional regulator | - |
| ETT63_RS03405 (ETT63_03405) | - | 666332..667093 (+) | 762 | WP_002995753.1 | DUF3169 family protein | - |
| ETT63_RS03410 (ETT63_03410) | - | 667112..667822 (+) | 711 | WP_076634494.1 | CPBP family intramembrane glutamic endopeptidase | - |
| ETT63_RS03420 (ETT63_03420) | - | 667894..669016 (-) | 1123 | Protein_597 | ISAs1-like element IS1548 family transposase | - |
| ETT63_RS03430 (ETT63_03430) | - | 669216..670372 (-) | 1157 | Protein_598 | IS3 family transposase | - |
| ETT63_RS03440 (ETT63_03440) | - | 670510..671736 (-) | 1227 | WP_391592273.1 | chloride channel protein | - |
| ETT63_RS03445 (ETT63_03445) | nrdF | 671798..672757 (-) | 960 | WP_002987365.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| ETT63_RS03450 (ETT63_03450) | nrdE | 673090..675249 (-) | 2160 | WP_136267883.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| ETT63_RS03455 (ETT63_03455) | - | 675269..675487 (-) | 219 | WP_002989242.1 | redoxin NrdH | - |
| ETT63_RS03460 (ETT63_03460) | - | 675880..676143 (+) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| ETT63_RS03465 (ETT63_03465) | ptsP | 676148..677881 (+) | 1734 | WP_136267882.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| ETT63_RS03470 (ETT63_03470) | - | 678066..679493 (+) | 1428 | WP_053308453.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| ETT63_RS03475 (ETT63_03475) | - | 679587..680861 (+) | 1275 | WP_002989251.1 | polysaccharide deacetylase family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69394.45 Da Isoelectric Point: 4.8408
>NTDB_id=341487 ETT63_RS03375 WP_002995768.1 657488..659293(+) (pepF) [Streptococcus pyogenes strain emm89.14]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=341487 ETT63_RS03375 WP_002995768.1 657488..659293(+) (pepF) [Streptococcus pyogenes strain emm89.14]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCAGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGACGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCAGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGACGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
70.715 |
100 |
0.707 |