Detailed information NTG0341376

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ETT65_RS03510
• Genome accession: NZ_CP035434
• Coordinates: 646057..647094 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain emm75.1
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 641057..652094

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT65_RS03485 (ETT65_03485)	-	641321..642652 (+)	1332	WP_009880963.1	dipeptidase	-
ETT65_RS03490 (ETT65_03490)	arcC	642672..643622 (+)	951	WP_010922501.1	carbamate kinase	-
ETT65_RS03495 (ETT65_03495)	asnA	643935..644927 (+)	993	WP_136075889.1	aspartate--ammonia ligase	-
ETT65_RS03500 (ETT65_03500)	rsmD	645050..645589 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ETT65_RS03505 (ETT65_03505)	coaD	645579..646070 (+)	492	WP_014407698.1	pantetheine-phosphate adenylyltransferase	-
ETT65_RS03510 (ETT65_03510)	sepM	646057..647094 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ETT65_RS03515 (ETT65_03515)	-	647508..648485 (+)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
ETT65_RS03520 (ETT65_03520)	-	648933..649553 (+)	621	WP_168390490.1	YutD family protein	-
ETT65_RS03525 (ETT65_03525)	rlmN	649557..650636 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ETT65_RS03530 (ETT65_03530)	-	650718..651344 (-)	627	WP_002983834.1	A24 family peptidase	-
ETT65_RS03535 (ETT65_03535)	-	651567..652094 (+)	528	WP_015057890.1	DNA starvation/stationary phase protection protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=341376 ETT65_RS03510 WP_010922499.1 646057..647094(+) (sepM) [Streptococcus pyogenes strain emm75.1]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=341376 ETT65_RS03510 WP_010922499.1 646057..647094(+) (sepM) [Streptococcus pyogenes strain emm75.1]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693