Detailed information NTG0341282

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ETT67_RS06375
• Genome accession: NZ_CP035432
• Coordinates: 1236679..1237716 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain emm11
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1231679..1242716

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT67_RS06355 (ETT67_06345)	-	1232430..1233056 (+)	627	WP_023079342.1	A24 family peptidase	-
ETT67_RS06360 (ETT67_06350)	rlmN	1233138..1234217 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ETT67_RS06365 (ETT67_06355)	-	1234221..1234841 (-)	621	WP_023079340.1	YutD family protein	-
ETT67_RS06370 (ETT67_06360)	-	1235289..1236265 (-)	977	Protein_1191	LacI family DNA-binding transcriptional regulator	-
ETT67_RS06375 (ETT67_06365)	sepM	1236679..1237716 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ETT67_RS06380 (ETT67_06370)	coaD	1237703..1238194 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ETT67_RS06385 (ETT67_06375)	rsmD	1238184..1238723 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ETT67_RS06390 (ETT67_06380)	asnA	1238846..1239838 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
ETT67_RS06395 (ETT67_06385)	arcC	1240151..1241101 (-)	951	WP_010922501.1	carbamate kinase	-
ETT67_RS06400 (ETT67_06390)	-	1241121..1242452 (-)	1332	WP_115224608.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=341282 ETT67_RS06375 WP_010922499.1 1236679..1237716(-) (sepM) [Streptococcus pyogenes strain emm11]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=341282 ETT67_RS06375 WP_010922499.1 1236679..1237716(-) (sepM) [Streptococcus pyogenes strain emm11]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693