Detailed information NTG0341177

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ETT69_RS06495
• Genome accession: NZ_CP035430
• Coordinates: 1262376..1263413 (-)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain emm55
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1257376..1268413

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT69_RS06475 (ETT69_06465)	-	1258126..1258752 (+)	627	WP_032460544.1	A24 family peptidase	-
ETT69_RS06480 (ETT69_06470)	rlmN	1258834..1259913 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ETT69_RS06485 (ETT69_06475)	-	1259917..1260537 (-)	621	WP_032460543.1	YutD family protein	-
ETT69_RS06490 (ETT69_06480)	-	1260985..1261962 (-)	978	WP_011054718.1	LacI family DNA-binding transcriptional regulator	-
ETT69_RS06495 (ETT69_06485)	sepM	1262376..1263413 (-)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
ETT69_RS06500 (ETT69_06490)	coaD	1263400..1263891 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ETT69_RS06505 (ETT69_06495)	rsmD	1263881..1264420 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ETT69_RS06510 (ETT69_06500)	asnA	1264543..1265535 (-)	993	WP_032460542.1	aspartate--ammonia ligase	-
ETT69_RS06515 (ETT69_06505)	arcC	1265848..1266798 (-)	951	WP_032460541.1	carbamate kinase	-
ETT69_RS06520 (ETT69_06510)	-	1267102..1268331 (+)	1230	WP_032460617.1	IS110 family transposase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=341177 ETT69_RS06495 WP_002983824.1 1262376..1263413(-) (sepM) [Streptococcus pyogenes strain emm55]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=341177 ETT69_RS06495 WP_002983824.1 1262376..1263413(-) (sepM) [Streptococcus pyogenes strain emm55]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGCAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69