Detailed information    

insolico Bioinformatically predicted

Overview

Name   pepF   Type   Regulator
Locus tag   ETT69_RS06130 Genome accession   NZ_CP035430
Coordinates   1186281..1188086 (-) Length   601 a.a.
NCBI ID   WP_136019212.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm55     
Function   degradation of XIP; competence shut-off (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1164663..1213074 1186281..1188086 within 0


Gene organization within MGE regions


Location: 1164663..1213074
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT69_RS06035 (ETT69_06025) - 1164701..1165975 (-) 1275 WP_136019332.1 polysaccharide deacetylase family protein -
  ETT69_RS06040 (ETT69_06030) - 1166070..1167497 (-) 1428 WP_023078833.1 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase -
  ETT69_RS06045 (ETT69_06035) ptsP 1167682..1169415 (-) 1734 WP_023078834.1 phosphoenolpyruvate--protein phosphotransferase -
  ETT69_RS06050 (ETT69_06040) - 1169420..1169683 (-) 264 WP_002984031.1 phosphocarrier protein HPr -
  ETT69_RS06055 (ETT69_06045) - 1170076..1170294 (+) 219 WP_002989242.1 redoxin NrdH -
  ETT69_RS06060 (ETT69_06050) nrdE 1170314..1172473 (+) 2160 WP_023078836.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
  ETT69_RS06065 (ETT69_06055) nrdF 1172806..1173765 (+) 960 WP_002987365.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
  ETT69_RS06070 (ETT69_06060) - 1173740..1175053 (+) 1314 WP_136019331.1 chloride channel protein -
  ETT69_RS06080 (ETT69_06070) - 1175191..1176346 (+) 1156 Protein_1133 IS3 family transposase -
  ETT69_RS06085 (ETT69_06075) - 1176438..1177133 (-) 696 WP_002995750.1 CPBP family intramembrane glutamic endopeptidase -
  ETT69_RS06090 (ETT69_06080) - 1177152..1177913 (-) 762 WP_136019629.1 DUF3169 family protein -
  ETT69_RS06095 (ETT69_06085) - 1177910..1178125 (-) 216 WP_002989220.1 helix-turn-helix transcriptional regulator -
  ETT69_RS06100 (ETT69_06090) alaS 1178486..1181104 (-) 2619 WP_136019628.1 alanine--tRNA ligase -
  ETT69_RS06110 (ETT69_06100) - 1181586..1182719 (-) 1134 WP_136019182.1 ISAs1-like element IS1548 family transposase -
  ETT69_RS06115 (ETT69_06105) prsA 1182817..1183872 (-) 1056 WP_063812310.1 peptidylprolyl isomerase PrsA -
  ETT69_RS06120 (ETT69_06110) - 1183935..1184642 (-) 708 WP_063631966.1 O-methyltransferase -
  ETT69_RS06125 (ETT69_06115) - 1184708..1185904 (-) 1197 WP_063631969.1 OFA family MFS transporter -
  ETT69_RS06130 (ETT69_06120) pepF 1186281..1188086 (-) 1806 WP_136019212.1 oligoendopeptidase F Regulator
  ETT69_RS06135 (ETT69_06125) - 1188099..1189061 (-) 963 WP_002983995.1 competence protein CoiA -
  ETT69_RS06140 (ETT69_06130) - 1189357..1190073 (-) 717 WP_011528761.1 pseudouridine synthase -
  ETT69_RS06145 (ETT69_06135) nagB 1190192..1190896 (-) 705 WP_021340997.1 glucosamine-6-phosphate deaminase -
  ETT69_RS06150 (ETT69_06140) queA 1191098..1192126 (+) 1029 WP_002983989.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
  ETT69_RS06155 (ETT69_06145) - 1192133..1193353 (+) 1221 WP_136019211.1 DUF3114 domain-containing protein -
  ETT69_RS06160 (ETT69_06150) - 1193467..1193889 (-) 423 WP_281726901.1 hypothetical protein -
  ETT69_RS10065 - 1193907..1194044 (-) 138 WP_281726900.1 hypothetical protein -
  ETT69_RS06165 (ETT69_06155) - 1194041..1194289 (-) 249 WP_010922432.1 serine hydrolase -
  ETT69_RS06170 (ETT69_06160) - 1194345..1194500 (-) 156 WP_227868730.1 hypothetical protein -
  ETT69_RS06175 (ETT69_06165) sodA 1194667..1195272 (-) 606 WP_002983977.1 superoxide dismutase SodA -
  ETT69_RS06180 (ETT69_06170) holA 1195369..1196409 (-) 1041 WP_011888795.1 DNA polymerase III subunit delta -
  ETT69_RS06185 (ETT69_06175) - 1196480..1198723 (-) 2244 WP_136019210.1 DNA internalization-related competence protein ComEC/Rec2 -
  ETT69_RS06190 (ETT69_06180) - 1198704..1199366 (-) 663 WP_136019209.1 ComEA family DNA-binding protein -
  ETT69_RS06195 (ETT69_06185) - 1199566..1200306 (-) 741 WP_168389123.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
  ETT69_RS06200 (ETT69_06190) - 1200424..1201200 (+) 777 WP_136019207.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  ETT69_RS06205 (ETT69_06195) - 1201190..1201468 (+) 279 WP_011017953.1 GIY-YIG nuclease family protein -
  ETT69_RS06210 (ETT69_06200) - 1201492..1203492 (-) 2001 WP_032465086.1 potassium transporter Kup -
  ETT69_RS06215 (ETT69_06205) - 1203621..1205240 (-) 1620 WP_020905305.1 DEAD/DEAH box helicase -
  ETT69_RS06220 (ETT69_06210) - 1205547..1207091 (-) 1545 WP_136019206.1 peptide chain release factor 3 -
  ETT69_RS06230 (ETT69_06220) - 1207339..1208034 (-) 696 WP_002983946.1 TIGR02206 family membrane protein -
  ETT69_RS06235 (ETT69_06225) murF 1208114..1209505 (-) 1392 WP_010922441.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
  ETT69_RS06240 (ETT69_06230) - 1209701..1210747 (-) 1047 WP_023610118.1 D-alanine--D-alanine ligase -
  ETT69_RS06245 (ETT69_06235) recR 1210848..1211444 (-) 597 WP_032465090.1 recombination mediator RecR -
  ETT69_RS10150 (ETT69_06240) - 1211491..1211682 (-) 192 WP_002983936.1 hypothetical protein -
  ETT69_RS06255 (ETT69_06245) - 1212243..1213022 (-) 780 WP_014407680.1 formate/nitrite transporter family protein -

Sequence

Protein


Download         Length: 601 a.a.        Molecular weight: 69420.48 Da        Isoelectric Point: 4.8042

>NTDB_id=341174 ETT69_RS06130 WP_136019212.1 1186281..1188086(-) (pepF) [Streptococcus pyogenes strain emm55]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPISETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIYQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS

Nucleotide


Download         Length: 1806 bp        

>NTDB_id=341174 ETT69_RS06130 WP_136019212.1 1186281..1188086(-) (pepF) [Streptococcus pyogenes strain emm55]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAAAAAGTCTATGTTTATGCTCACATGAAAAATGAT
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGACCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCAATATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTAGCTGTTTTTGGTAAAGATTACGCAGATCGTGTGCATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGTTCTGGAGCTTATTCGGGTGGTTCCTATGATACCAATGCCTTTATGCTATTAAACT
GGCAAGATACCTTAGACAATCTATACACTTTAGTTCATGAAACTGGGCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGAGATTACAGTATTTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAGGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTTATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGACGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA

Domains

Predicted by InterproScan.

Oligopeptidase F (Peptidase_M3_N)

(112-181)

Peptidase family M3 (Peptidase_M3)

(202-581)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pepF Streptococcus salivarius strain HSISS4

70.383

100

0.704

Multiple sequence alignment