Detailed information NTG0341123

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ETT70_RS06340
• Genome accession: NZ_CP035429
• Coordinates: 1207567..1208604 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain emmNA
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1202567..1213604

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT70_RS06320 (ETT70_06310)	-	1203317..1203943 (+)	627	WP_136275962.1	A24 family peptidase	-
ETT70_RS06325 (ETT70_06315)	rlmN	1204025..1205104 (-)	1080	WP_111680790.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ETT70_RS06330 (ETT70_06320)	-	1205108..1205728 (-)	621	WP_002992791.1	YutD family protein	-
ETT70_RS06335 (ETT70_06325)	-	1206176..1207153 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
ETT70_RS06340 (ETT70_06330)	sepM	1207567..1208604 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ETT70_RS06345 (ETT70_06335)	coaD	1208591..1209082 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ETT70_RS06350 (ETT70_06340)	rsmD	1209072..1209611 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ETT70_RS06355 (ETT70_06345)	asnA	1209734..1210726 (-)	993	WP_023611792.1	aspartate--ammonia ligase	-
ETT70_RS06360 (ETT70_06350)	arcC	1211039..1211989 (-)	951	WP_109828594.1	carbamate kinase	-
ETT70_RS06365 (ETT70_06355)	-	1212009..1213340 (-)	1332	WP_136275963.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=341123 ETT70_RS06340 WP_010922499.1 1207567..1208604(-) (sepM) [Streptococcus pyogenes strain emmNA]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=341123 ETT70_RS06340 WP_010922499.1 1207567..1208604(-) (sepM) [Streptococcus pyogenes strain emmNA]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693