Detailed information    

insolico Bioinformatically predicted

Overview

Name   pepF   Type   Regulator
Locus tag   ETT70_RS05980 Genome accession   NZ_CP035429
Coordinates   1133235..1135040 (-) Length   601 a.a.
NCBI ID   WP_111693281.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emmNA     
Function   degradation of XIP; competence shut-off (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1112944..1160026 1133235..1135040 within 0


Gene organization within MGE regions


Location: 1112944..1160026
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT70_RS05895 (ETT70_05885) - 1112982..1114256 (-) 1275 WP_136275987.1 polysaccharide deacetylase family protein -
  ETT70_RS05900 (ETT70_05890) - 1114351..1115778 (-) 1428 WP_136019896.1 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase -
  ETT70_RS05905 (ETT70_05895) ptsP 1115963..1117696 (-) 1734 WP_002984033.1 phosphoenolpyruvate--protein phosphotransferase -
  ETT70_RS05910 (ETT70_05900) - 1117701..1117964 (-) 264 WP_002984031.1 phosphocarrier protein HPr -
  ETT70_RS05915 (ETT70_05905) - 1118357..1118575 (+) 219 WP_002989242.1 redoxin NrdH -
  ETT70_RS05920 (ETT70_05910) nrdE 1118595..1120754 (+) 2160 WP_136275988.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
  ETT70_RS05925 (ETT70_05915) nrdF 1121087..1122046 (+) 960 WP_011017933.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
  ETT70_RS05930 (ETT70_05920) - 1122108..1123334 (+) 1227 WP_372237151.1 chloride channel protein -
  ETT70_RS05940 (ETT70_05930) - 1123472..1124622 (+) 1151 Protein_1102 IS3 family transposase -
  ETT70_RS05945 (ETT70_05935) - 1124719..1125414 (-) 696 WP_002984013.1 CPBP family intramembrane glutamic endopeptidase -
  ETT70_RS05950 (ETT70_05940) - 1125433..1126194 (-) 762 WP_014407666.1 DUF3169 family protein -
  ETT70_RS05955 (ETT70_05945) - 1126191..1126406 (-) 216 WP_002989220.1 helix-turn-helix transcriptional regulator -
  ETT70_RS05960 (ETT70_05950) alaS 1126767..1129385 (-) 2619 WP_115223157.1 alanine--tRNA ligase -
  ETT70_RS05965 (ETT70_05955) prsA 1129772..1130827 (-) 1056 WP_002984003.1 peptidylprolyl isomerase PrsA -
  ETT70_RS05970 (ETT70_05960) - 1130890..1131597 (-) 708 WP_002989211.1 O-methyltransferase -
  ETT70_RS05975 (ETT70_05965) - 1131663..1132859 (-) 1197 WP_002995765.1 OFA family MFS transporter -
  ETT70_RS05980 (ETT70_05970) pepF 1133235..1135040 (-) 1806 WP_111693281.1 oligoendopeptidase F Regulator
  ETT70_RS05985 (ETT70_05975) - 1135053..1136015 (-) 963 WP_111674624.1 competence protein CoiA -
  ETT70_RS05990 (ETT70_05980) - 1136311..1137027 (-) 717 WP_032462853.1 pseudouridine synthase -
  ETT70_RS05995 (ETT70_05985) nagB 1137146..1137850 (-) 705 WP_009880651.1 glucosamine-6-phosphate deaminase -
  ETT70_RS06000 (ETT70_05990) queA 1138052..1139080 (+) 1029 WP_002983989.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
  ETT70_RS06005 (ETT70_05995) - 1139087..1140307 (+) 1221 WP_136108760.1 DUF3114 domain-containing protein -
  ETT70_RS06010 (ETT70_06000) - 1140421..1141011 (-) 591 WP_011017945.1 serine hydrolase -
  ETT70_RS09575 (ETT70_06005) - 1141008..1141256 (-) 249 WP_136108759.1 serine hydrolase -
  ETT70_RS06020 (ETT70_06010) - 1141241..1141468 (-) 228 WP_010922433.1 hypothetical protein -
  ETT70_RS06025 (ETT70_06015) sodA 1141635..1142240 (-) 606 WP_023612500.1 superoxide dismutase SodA -
  ETT70_RS06030 (ETT70_06020) holA 1142337..1143377 (-) 1041 WP_136077189.1 DNA polymerase III subunit delta -
  ETT70_RS06035 (ETT70_06025) - 1143448..1145691 (-) 2244 WP_136095789.1 DNA internalization-related competence protein ComEC/Rec2 -
  ETT70_RS06040 (ETT70_06030) - 1145672..1146334 (-) 663 WP_136094078.1 ComEA family DNA-binding protein -
  ETT70_RS06045 (ETT70_06035) - 1146534..1147274 (-) 741 WP_186787887.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
  ETT70_RS06050 (ETT70_06040) - 1147392..1148168 (+) 777 WP_010922438.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  ETT70_RS06055 (ETT70_06045) - 1148158..1148436 (+) 279 WP_011017953.1 GIY-YIG nuclease family protein -
  ETT70_RS06060 (ETT70_06050) - 1148460..1150460 (-) 2001 WP_136275953.1 potassium transporter Kup -
  ETT70_RS06065 (ETT70_06055) - 1150588..1152207 (-) 1620 WP_136077185.1 DEAD/DEAH box helicase -
  ETT70_RS06070 (ETT70_06060) - 1152514..1154058 (-) 1545 WP_032465087.1 peptide chain release factor 3 -
  ETT70_RS06080 (ETT70_06070) - 1154306..1155001 (-) 696 WP_002983946.1 TIGR02206 family membrane protein -
  ETT70_RS06085 (ETT70_06075) murF 1155081..1156472 (-) 1392 WP_136077184.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
  ETT70_RS06090 (ETT70_06080) - 1156663..1157709 (-) 1047 WP_011017958.1 D-alanine--D-alanine ligase -
  ETT70_RS06095 (ETT70_06085) recR 1157810..1158406 (-) 597 WP_002983939.1 recombination mediator RecR -
  ETT70_RS09580 (ETT70_06090) - 1158453..1158635 (-) 183 WP_011888786.1 penicillin-binding protein -
  ETT70_RS06105 (ETT70_06095) - 1159195..1159974 (-) 780 WP_014635570.1 formate/nitrite transporter family protein -

Sequence

Protein


Download         Length: 601 a.a.        Molecular weight: 69408.48 Da        Isoelectric Point: 4.8408

>NTDB_id=341120 ETT70_RS05980 WP_111693281.1 1133235..1135040(-) (pepF) [Streptococcus pyogenes strain emmNA]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKILAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS

Nucleotide


Download         Length: 1806 bp        

>NTDB_id=341120 ETT70_RS05980 WP_111693281.1 1133235..1135040(-) (pepF) [Streptococcus pyogenes strain emmNA]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAAGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGATTTTGGCTGTTTTTGGTAAGGATTACGCAGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCAG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA

Domains

Predicted by InterproScan.

Peptidase family M3 (Peptidase_M3)

(202-581)

Oligopeptidase F (Peptidase_M3_N)

(112-181)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pepF Streptococcus salivarius strain HSISS4

70.549

100

0.705

Multiple sequence alignment