Detailed information NTG0341068

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ETT71_RS06320
• Genome accession: NZ_CP035428
• Coordinates: 1233567..1234604 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain emmSTG866.1
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1228567..1239604

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT71_RS06300 (ETT71_06295)	-	1229317..1229943 (+)	627	WP_002989076.1	A24 family peptidase	-
ETT71_RS06305 (ETT71_06300)	rlmN	1230025..1231104 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
ETT71_RS06310 (ETT71_06305)	-	1231108..1231728 (-)	621	WP_002992791.1	YutD family protein	-
ETT71_RS06315 (ETT71_06310)	-	1232176..1233153 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
ETT71_RS06320 (ETT71_06315)	sepM	1233567..1234604 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
ETT71_RS06325 (ETT71_06320)	coaD	1234591..1235082 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
ETT71_RS06330 (ETT71_06325)	rsmD	1235072..1235611 (-)	540	WP_136093431.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ETT71_RS06335 (ETT71_06330)	asnA	1235734..1236726 (-)	993	WP_020905328.1	aspartate--ammonia ligase	-
ETT71_RS06340 (ETT71_06335)	arcC	1237039..1237989 (-)	951	WP_136093429.1	carbamate kinase	-
ETT71_RS06345 (ETT71_06340)	-	1238009..1239340 (-)	1332	WP_030126384.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=341068 ETT71_RS06320 WP_010922499.1 1233567..1234604(-) (sepM) [Streptococcus pyogenes strain emmSTG866.1]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=341068 ETT71_RS06320 WP_010922499.1 1233567..1234604(-) (sepM) [Streptococcus pyogenes strain emmSTG866.1]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693