Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | ETT71_RS05960 | Genome accession | NZ_CP035428 |
| Coordinates | 1159283..1161088 (-) | Length | 601 a.a. |
| NCBI ID | WP_136094945.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain emmSTG866.1 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1138992..1186056 | 1159283..1161088 | within | 0 |
Gene organization within MGE regions
Location: 1138992..1186056
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ETT71_RS05875 (ETT71_05870) | - | 1139030..1140304 (-) | 1275 | WP_136093453.1 | polysaccharide deacetylase family protein | - |
| ETT71_RS05880 (ETT71_05875) | - | 1140399..1141826 (-) | 1428 | WP_002984035.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| ETT71_RS05885 (ETT71_05880) | ptsP | 1142011..1143744 (-) | 1734 | WP_002984033.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| ETT71_RS05890 (ETT71_05885) | - | 1143749..1144012 (-) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| ETT71_RS05895 (ETT71_05890) | - | 1144405..1144623 (+) | 219 | WP_002989242.1 | redoxin NrdH | - |
| ETT71_RS05900 (ETT71_05895) | nrdE | 1144643..1146802 (+) | 2160 | WP_136093452.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| ETT71_RS05905 (ETT71_05900) | nrdF | 1147135..1148094 (+) | 960 | WP_002987365.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| ETT71_RS05910 (ETT71_05905) | - | 1148156..1149382 (+) | 1227 | WP_391592275.1 | chloride channel protein | - |
| ETT71_RS05920 (ETT71_05915) | - | 1149520..1150676 (+) | 1157 | Protein_1097 | IS3 family transposase | - |
| ETT71_RS05925 (ETT71_05920) | - | 1150768..1151463 (-) | 696 | WP_136077192.1 | CPBP family intramembrane glutamic endopeptidase | - |
| ETT71_RS05930 (ETT71_05925) | - | 1151482..1152243 (-) | 762 | WP_053308456.1 | DUF3169 family protein | - |
| ETT71_RS05935 (ETT71_05930) | - | 1152240..1152455 (-) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| ETT71_RS05940 (ETT71_05935) | alaS | 1152816..1155434 (-) | 2619 | WP_136093451.1 | alanine--tRNA ligase | - |
| ETT71_RS05945 (ETT71_05940) | prsA | 1155821..1156876 (-) | 1056 | WP_002984003.1 | peptidylprolyl isomerase PrsA | - |
| ETT71_RS05950 (ETT71_05945) | - | 1156939..1157646 (-) | 708 | WP_011017939.1 | O-methyltransferase | - |
| ETT71_RS05955 (ETT71_05950) | - | 1157712..1158908 (-) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| ETT71_RS05960 (ETT71_05955) | pepF | 1159283..1161088 (-) | 1806 | WP_136094945.1 | oligoendopeptidase F | Regulator |
| ETT71_RS05965 (ETT71_05960) | - | 1161101..1162063 (-) | 963 | WP_136094944.1 | competence protein CoiA | - |
| ETT71_RS05970 (ETT71_05965) | - | 1162358..1163074 (-) | 717 | WP_136094943.1 | pseudouridine synthase | - |
| ETT71_RS05975 (ETT71_05970) | nagB | 1163193..1163897 (-) | 705 | WP_021340997.1 | glucosamine-6-phosphate deaminase | - |
| ETT71_RS05980 (ETT71_05975) | queA | 1164099..1165127 (+) | 1029 | WP_111703224.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| ETT71_RS05985 (ETT71_05980) | - | 1165132..1166352 (+) | 1221 | WP_136269979.1 | DUF3114 domain-containing protein | - |
| ETT71_RS05990 (ETT71_05985) | - | 1166466..1167288 (-) | 823 | Protein_1111 | serine hydrolase | - |
| ETT71_RS06000 (ETT71_05995) | - | 1167273..1167500 (-) | 228 | WP_011054657.1 | hypothetical protein | - |
| ETT71_RS06005 (ETT71_06000) | sodA | 1167667..1168272 (-) | 606 | WP_023612500.1 | superoxide dismutase SodA | - |
| ETT71_RS06010 (ETT71_06005) | holA | 1168369..1169409 (-) | 1041 | WP_136269978.1 | DNA polymerase III subunit delta | - |
| ETT71_RS06015 (ETT71_06010) | - | 1169480..1171723 (-) | 2244 | WP_136106902.1 | DNA internalization-related competence protein ComEC/Rec2 | - |
| ETT71_RS06020 (ETT71_06015) | - | 1171704..1172366 (-) | 663 | WP_002983967.1 | ComEA family DNA-binding protein | - |
| ETT71_RS06025 (ETT71_06020) | - | 1172566..1173306 (-) | 741 | WP_002989170.1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase | - |
| ETT71_RS06030 (ETT71_06025) | - | 1173424..1174200 (+) | 777 | WP_010922438.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| ETT71_RS06035 (ETT71_06030) | - | 1174190..1174468 (+) | 279 | WP_002989164.1 | GIY-YIG nuclease family protein | - |
| ETT71_RS06040 (ETT71_06035) | - | 1174492..1176480 (-) | 1989 | WP_136288913.1 | potassium transporter Kup | - |
| ETT71_RS06045 (ETT71_06040) | - | 1176608..1178227 (-) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| ETT71_RS06050 (ETT71_06045) | - | 1178534..1180078 (-) | 1545 | WP_002989155.1 | peptide chain release factor 3 | - |
| ETT71_RS06060 (ETT71_06055) | - | 1180326..1181021 (-) | 696 | WP_136093443.1 | TIGR02206 family membrane protein | - |
| ETT71_RS06065 (ETT71_06060) | murF | 1181101..1182492 (-) | 1392 | WP_010922441.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| ETT71_RS06070 (ETT71_06065) | - | 1182683..1183729 (-) | 1047 | WP_002989146.1 | D-alanine--D-alanine ligase | - |
| ETT71_RS06075 (ETT71_06070) | recR | 1183830..1184426 (-) | 597 | WP_032465090.1 | recombination mediator RecR | - |
| ETT71_RS09440 (ETT71_06075) | - | 1184473..1184664 (-) | 192 | WP_136040090.1 | penicillin-binding protein | - |
| ETT71_RS06085 (ETT71_06080) | - | 1185225..1186004 (-) | 780 | WP_136040091.1 | formate/nitrite transporter family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69450.51 Da Isoelectric Point: 4.8042
>NTDB_id=341065 ETT71_RS05960 WP_136094945.1 1159283..1161088(-) (pepF) [Streptococcus pyogenes strain emmSTG866.1]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGYLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLTYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGYLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLTYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=341065 ETT71_RS05960 WP_136094945.1 1159283..1161088(-) (pepF) [Streptococcus pyogenes strain emmSTG866.1]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTTATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCAGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCAG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGACCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTTATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCAGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCAG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGACCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
70.715 |
100 |
0.707 |