Detailed information    

insolico Bioinformatically predicted

Overview

Name   pepF   Type   Regulator
Locus tag   ETT72_RS06000 Genome accession   NZ_CP035427
Coordinates   1154562..1156367 (-) Length   601 a.a.
NCBI ID   WP_010922425.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm74     
Function   degradation of XIP; competence shut-off (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1134183..1181369 1154562..1156367 within 0


Gene organization within MGE regions


Location: 1134183..1181369
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT72_RS05920 (ETT72_05915) - 1134221..1135495 (-) 1275 WP_002989251.1 polysaccharide deacetylase family protein -
  ETT72_RS05925 (ETT72_05920) - 1135590..1137017 (-) 1428 WP_011284931.1 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase -
  ETT72_RS05930 (ETT72_05925) ptsP 1137202..1138935 (-) 1734 WP_002984033.1 phosphoenolpyruvate--protein phosphotransferase -
  ETT72_RS05935 (ETT72_05930) - 1138940..1139203 (-) 264 WP_002984031.1 phosphocarrier protein HPr -
  ETT72_RS05940 (ETT72_05935) - 1139596..1139814 (+) 219 WP_002989242.1 redoxin NrdH -
  ETT72_RS05945 (ETT72_05940) nrdE 1139834..1141993 (+) 2160 WP_110410804.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
  ETT72_RS05950 (ETT72_05945) nrdF 1142455..1143414 (+) 960 WP_002987365.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
  ETT72_RS05955 (ETT72_05950) - 1143476..1144702 (+) 1227 WP_374151783.1 chloride channel protein -
  ETT72_RS05960 (ETT72_05955) - 1144798..1145948 (+) 1151 Protein_1121 IS3 family transposase -
  ETT72_RS05965 (ETT72_05960) - 1146046..1146741 (-) 696 WP_032464429.1 CPBP family intramembrane glutamic endopeptidase -
  ETT72_RS05970 (ETT72_05965) - 1146760..1147521 (-) 762 WP_002995753.1 DUF3169 family protein -
  ETT72_RS05975 (ETT72_05970) - 1147518..1147733 (-) 216 WP_002989220.1 helix-turn-helix transcriptional regulator -
  ETT72_RS05980 (ETT72_05975) alaS 1148094..1150712 (-) 2619 WP_032464430.1 alanine--tRNA ligase -
  ETT72_RS05985 (ETT72_05980) prsA 1151099..1152154 (-) 1056 WP_002984003.1 peptidylprolyl isomerase PrsA -
  ETT72_RS05990 (ETT72_05985) - 1152217..1152924 (-) 708 WP_002989211.1 O-methyltransferase -
  ETT72_RS05995 (ETT72_05990) - 1152990..1154186 (-) 1197 WP_002995765.1 OFA family MFS transporter -
  ETT72_RS06000 (ETT72_05995) pepF 1154562..1156367 (-) 1806 WP_010922425.1 oligoendopeptidase F Regulator
  ETT72_RS06005 (ETT72_06000) - 1156380..1157342 (-) 963 WP_002983995.1 competence protein CoiA -
  ETT72_RS06010 (ETT72_06005) - 1157637..1158353 (-) 717 WP_002995774.1 pseudouridine synthase -
  ETT72_RS06015 (ETT72_06010) nagB 1158472..1159176 (-) 705 WP_010922428.1 glucosamine-6-phosphate deaminase -
  ETT72_RS06020 (ETT72_06015) queA 1159378..1160406 (+) 1029 WP_010922429.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
  ETT72_RS06025 (ETT72_06020) - 1160413..1161633 (+) 1221 WP_010922430.1 DUF3114 domain-containing protein -
  ETT72_RS06030 (ETT72_06025) - 1161747..1162337 (-) 591 WP_032464432.1 serine hydrolase -
  ETT72_RS06035 (ETT72_06030) - 1162334..1162582 (-) 249 WP_010922432.1 serine hydrolase -
  ETT72_RS06040 (ETT72_06035) - 1162567..1162794 (-) 228 WP_010922433.1 hypothetical protein -
  ETT72_RS06045 (ETT72_06040) sodA 1162961..1163566 (-) 606 WP_032464433.1 superoxide dismutase SodA -
  ETT72_RS06050 (ETT72_06045) holA 1163663..1164703 (-) 1041 WP_010922435.1 DNA polymerase III subunit delta -
  ETT72_RS06055 (ETT72_06050) - 1164774..1167017 (-) 2244 WP_032464434.1 DNA internalization-related competence protein ComEC/Rec2 -
  ETT72_RS06060 (ETT72_06055) - 1166998..1167660 (-) 663 WP_002983967.1 ComEA family DNA-binding protein -
  ETT72_RS06065 (ETT72_06060) - 1167860..1168600 (-) 741 WP_002989170.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
  ETT72_RS06070 (ETT72_06065) - 1168718..1169494 (+) 777 WP_002994360.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  ETT72_RS06075 (ETT72_06070) - 1169484..1169762 (+) 279 WP_002989164.1 GIY-YIG nuclease family protein -
  ETT72_RS06080 (ETT72_06075) - 1169786..1171786 (-) 2001 WP_030126409.1 potassium transporter Kup -
  ETT72_RS06085 (ETT72_06080) - 1171914..1173533 (-) 1620 WP_136292350.1 DEAD/DEAH box helicase -
  ETT72_RS06090 (ETT72_06085) - 1173840..1175384 (-) 1545 WP_032464436.1 peptide chain release factor 3 -
  ETT72_RS06100 (ETT72_06095) - 1175632..1176327 (-) 696 WP_002994365.1 TIGR02206 family membrane protein -
  ETT72_RS06105 (ETT72_06100) murF 1176431..1177798 (-) 1368 WP_032464437.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
  ETT72_RS06110 (ETT72_06105) - 1177997..1179043 (-) 1047 WP_032464439.1 D-alanine--D-alanine ligase -
  ETT72_RS06115 (ETT72_06110) recR 1179144..1179740 (-) 597 WP_032464441.1 recombination mediator RecR -
  ETT72_RS09930 (ETT72_06115) - 1179787..1179978 (-) 192 WP_032464443.1 hypothetical protein -
  ETT72_RS06125 (ETT72_06120) - 1180538..1181317 (-) 780 WP_014407680.1 formate/nitrite transporter family protein -

Sequence

Protein


Download         Length: 601 a.a.        Molecular weight: 69393.40 Da        Isoelectric Point: 4.7783

>NTDB_id=341009 ETT72_RS06000 WP_010922425.1 1154562..1156367(-) (pepF) [Streptococcus pyogenes strain emm74]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFILLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMEKGDYLEAAFKVFDERLTELEVLVSKGIHKS

Nucleotide


Download         Length: 1806 bp        

>NTDB_id=341009 ETT72_RS06000 WP_010922425.1 1154562..1156367(-) (pepF) [Streptococcus pyogenes strain emm74]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTTCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAAGATTACGCAGATCGTGTGCATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTTATTCTGTTGAATT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAATATTATGACAGAAGC
TCTCTTAAATGAGGTTCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCAG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGAAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA

Domains

Predicted by InterproScan.

Peptidase family M3 (Peptidase_M3)

(202-581)

Oligopeptidase F (Peptidase_M3_N)

(112-181)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pepF Streptococcus salivarius strain HSISS4

70.549

100

0.705

Multiple sequence alignment