Detailed information NTG0338942

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: EQW00_RS04870
• Genome accession: NZ_CP035288
• Coordinates: 996403..997449 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain ATCC 14990
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 991403..1002449

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQW00_RS04845 (EQW00_04845)	-	992544..993080 (+)	537	WP_001830372.1	hypothetical protein	-
EQW00_RS04850 (EQW00_04850)	-	993231..994217 (-)	987	WP_002457091.1	aromatic acid exporter family protein	-
EQW00_RS04855 (EQW00_04855)	map	994391..995146 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
EQW00_RS04860 (EQW00_04860)	-	995304..995690 (+)	387	WP_002489903.1	hypothetical protein	-
EQW00_RS04865 (EQW00_04865)	liaF	995705..996406 (+)	702	WP_002473931.1	cell wall-active antibiotics response protein LiaF	-
EQW00_RS04870 (EQW00_04870)	vraS	996403..997449 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
EQW00_RS04875 (EQW00_04875)	vraR	997439..998068 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
EQW00_RS04880 (EQW00_04880)	-	998125..999303 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
EQW00_RS04885 (EQW00_04885)	-	999710..999994 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
EQW00_RS04890 (EQW00_04890)	-	1000002..1000466 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
EQW00_RS04895 (EQW00_04895)	-	1000607..1000822 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
EQW00_RS04900 (EQW00_04900)	-	1000824..1002065 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=338942 EQW00_RS04870 WP_001830374.1 996403..997449(+) (vraS) [Staphylococcus epidermidis strain ATCC 14990]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=338942 EQW00_RS04870 WP_001830374.1 996403..997449(+) (vraS) [Staphylococcus epidermidis strain ATCC 14990]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTTAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTGTTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCATTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92