Detailed information NTG0338563

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EQH17_RS09055
• Genome accession: NZ_CP035263
• Coordinates: 1818232..1819269 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727278.1
• Uniprot ID: A0A4J2BD57
• Organism: Streptococcus pneumoniae strain TVO_1901922
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1813232..1824269

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH17_RS09030 (EQH17_09570)	-	1813971..1815302 (-)	1332	WP_000390043.1	hemolysin family protein	-
EQH17_RS09035 (EQH17_09575)	endA	1815593..1816417 (-)	825	WP_001036789.1	DNA-entry nuclease EndA	Machinery gene
EQH17_RS09040 (EQH17_09580)	-	1816456..1816644 (-)	189	WP_001813390.1	DNA-directed RNA polymerase subunit beta	-
EQH17_RS09045 (EQH17_09585)	murA	1816637..1817920 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
EQH17_RS09050 (EQH17_09590)	-	1817944..1818174 (-)	231	WP_000250392.1	DUF1146 family protein	-
EQH17_RS09055 (EQH17_09595)	sepM	1818232..1819269 (-)	1038	WP_000727278.1	SepM family pheromone-processing serine protease	Regulator
EQH17_RS09060 (EQH17_09600)	coaD	1819253..1819741 (-)	489	WP_001280769.1	pantetheine-phosphate adenylyltransferase	-
EQH17_RS09065 (EQH17_09605)	rsmD	1819731..1820270 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EQH17_RS09070 (EQH17_09610)	asnA	1820335..1821327 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
EQH17_RS09075 (EQH17_09620)	-	1821439..1822122 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
EQH17_RS09080 (EQH17_09625)	-	1822178..1822918 (-)	741	WP_000152703.1	RNA methyltransferase	-
EQH17_RS09085 (EQH17_09630)	-	1822952..1823230 (+)	279	WP_001174612.1	acylphosphatase	-
EQH17_RS09090 (EQH17_09635)	yidC	1823308..1824234 (+)	927	WP_000835955.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37510.55 Da
• Isoelectric Point: 5.0724

>NTDB_id=338563 EQH17_RS09055 WP_000727278.1 1818232..1819269(-) (sepM) [Streptococcus pneumoniae strain TVO_1901922]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNSP

Nucleotide

• Length: 1038 bp

>NTDB_id=338563 EQH17_RS09055 WP_000727278.1 1818232..1819269(-) (sepM) [Streptococcus pneumoniae strain TVO_1901922]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACGGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAAATCATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAGTCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A4J2BD57

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	60	98.551	0.591