Detailed information NTG0338253

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EQH21_RS09070
• Genome accession: NZ_CP035259
• Coordinates: 1792428..1793465 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain TVO_1901926
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1787428..1798465

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH21_RS09045 (EQH21_09505)	-	1788167..1789498 (-)	1332	WP_000390042.1	hemolysin family protein	-
EQH21_RS09050 (EQH21_09510)	endA	1789789..1790613 (-)	825	WP_001036784.1	DNA-entry nuclease EndA	Machinery gene
EQH21_RS09055 (EQH21_09515)	-	1790652..1790840 (-)	189	WP_001813390.1	DNA-directed RNA polymerase subunit beta	-
EQH21_RS09060 (EQH21_09520)	murA	1790833..1792116 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
EQH21_RS09065 (EQH21_09525)	-	1792140..1792370 (-)	231	WP_000250393.1	DUF1146 family protein	-
EQH21_RS09070 (EQH21_09530)	sepM	1792428..1793465 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
EQH21_RS09075 (EQH21_09535)	coaD	1793449..1793937 (-)	489	WP_001280746.1	pantetheine-phosphate adenylyltransferase	-
EQH21_RS09080 (EQH21_09540)	rsmD	1793927..1794466 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EQH21_RS09085 (EQH21_09545)	asnA	1794531..1795523 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
EQH21_RS09090 (EQH21_09555)	-	1795635..1796318 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
EQH21_RS09095 (EQH21_09560)	-	1796374..1797114 (-)	741	WP_000152701.1	RNA methyltransferase	-
EQH21_RS09100 (EQH21_09565)	-	1797148..1797426 (+)	279	WP_001174613.1	acylphosphatase	-
EQH21_RS09105 (EQH21_09570)	yidC	1797504..1798430 (+)	927	WP_000835943.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=338253 EQH21_RS09070 WP_000727277.1 1792428..1793465(-) (sepM) [Streptococcus pneumoniae strain TVO_1901926]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=338253 EQH21_RS09070 WP_000727277.1 1792428..1793465(-) (sepM) [Streptococcus pneumoniae strain TVO_1901926]
ATGAAAAAAAAGATTAGATGGCCCTTGTATGTCATTGCGGCCTTGATTGTGACCTTCTTGGCATTTGTGGTGCCTTTGCC
CTACTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCTACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGACTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGAAAAAATGGGATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591